| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 |
|---|---|---|---|---|---|---|---|---|---|
Revenues: | |||||||||
Revenue from Contract with Customer, Excluding Assessed Tax | |||||||||
6,832 | 72 | 72 | 1,194 | - | - | - | - | - | - |
Total revenues | |||||||||
- | - | - | - | 20,759 | 7,669 | 19,569 | 12,700 | 13,789 | 8,601 |
Operating expenses: | |||||||||
Research and development | |||||||||
12,349 | 33,975 | 53,192 | 64,305 | 56,387 | 41,046 | 29,942 | 20,342 | 17,289 | 20,178 |
General and administrative | |||||||||
11,317 | 12,860 | 17,011 | 18,391 | 19,130 | 11,533 | 7,429 | 4,932 | 3,637 | 3,921 |
Total operating expenses | |||||||||
23,666 | 46,835 | 70,203 | 82,696 | 75,517 | 52,579 | 37,371 | 25,274 | 20,926 | 24,099 |
Loss from operations | |||||||||
-16,834 | -46,763 | -70,131 | -81,502 | -54,758 | -44,910 | -17,802 | -12,574 | -7,137 | -15,498 |
Other income (expense): | |||||||||
Interest and other income | |||||||||
374 | 459 | 752 | 844 | 855 | 388 | 292 | 110 | 129 | 271 |
Interest and other expense | |||||||||
2,131 | 2,343 | 2,723 | 1,182 | 52 | 39 | 36 | 247 | 388 | 362 |
Loss on extinguishment of debt | |||||||||
- | - | - | - | - | - | - | -1,738 | - | - |
Loss from valuation of convertible note payable | |||||||||
- | - | - | - | -1,811 | -12,118 | -1,145 | -2,969 | - | - |
Loss before income taxes | |||||||||
-18,591 | -48,647 | -72,102 | -81,840 | -55,766 | -56,679 | -18,691 | -17,418 | -7,396 | -15,589 |
Income tax benefit | |||||||||
1 | 62 | -197 | -4 | -18 | 1 | -23 | -10 | 206 | -30 |
Net Income (Loss) Attributable to Parent | |||||||||
-18,592 | -48,709 | -71,905 | -81,836 | -55,748 | -56,680 | -18,668 | -17,408 | -7,602 | -15,559 |
Unrealized gain on short-term investments, net | |||||||||
- | - | -11 | 10 | 64 | -181 | 36 | 15 | -80 | 13 |
Comprehensive loss | |||||||||
- | - | -71,916 | -81,826 | -55,684 | -56,861 | -18,632 | -17,393 | -7,682 | -15,546 |
Net loss per share, basic and diluted (in dollars per share) | |||||||||
-1.08 | -5.59 | -11.47 | -18.59 | -1.08 | -1.29 | -0.49 | -2.12 | -85.82 | - |
Weighted average shares used to compute basic and diluted net loss per share (in shares) | |||||||||
17,260 | 8,718 | 6,269 | 4,401 | 51,411 | 44,090 | 38,479 | 8,212,538 | 88,582 | - |
Revenue under collaborations | |||||||||
Total revenues | |||||||||
6,832 | 72 | - | - | - | - | - | - | - | - |
Strategic Alliances and Collaborations | |||||||||
Total revenues | |||||||||
- | - | 72 | 1,194 | - | - | - | - | - | - |