| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | |
|---|---|---|---|---|---|---|
Cash flows from operating activities | ||||||
Net loss | ||||||
-94,733 | 99,937 | -73,169 | -62,967 | -22,811 | -4,003 | |
Adjustments to reconcile net loss to net cash used in operating activities | ||||||
Stock-based compensation expense | ||||||
26,854 | 16,641 | 10,605 | 7,031 | 2,921 | 319 | |
Net amortization of premiums and accretion of discounts on marketable debt securities | ||||||
1,196 | -755 | -1,815 | -2,004 | -311 | - | |
Depreciation and amortization | ||||||
7,200 | 4,000 | 2,700 | 544 | 80 | 0 | |
Net realized gains on sales and maturities of marketable securities | ||||||
5,990 | -39 | 479 | - | - | - | |
Imputed interest income from licensing | ||||||
2,951 | 8,946 | - | - | - | - | |
Unrealized gains on marketable equity securities | ||||||
31,784 | - | - | - | - | - | |
Unrealized foreign currency transaction gains | ||||||
- | - | - | - | - | -44 | |
Imputed interest on related party promissory notes | ||||||
- | - | - | - | - | 128 | |
Non-cash consideration received for licenses granted | ||||||
- | - | 420 | - | - | - | |
Other non-cash adjustments | ||||||
-268 | -14 | -73 | 399 | -24 | 3 | |
Changes in operating assets and liabilities | ||||||
Accounts receivable | ||||||
8,622 | 16,803 | -561 | -1,073 | 265 | 799 | |
Related party receivables | ||||||
- | - | - | - | - | -174 | |
Unbilled receivables | ||||||
- | - | - | - | - | 213 | |
Prepaid expenses | ||||||
973 | 400 | 3,559 | 755 | 992 | 28 | |
Other current assets | ||||||
499 | 2,069 | 402 | 159 | 851 | - | |
Operating lease right-of-use assets | ||||||
-2,431 | - | - | - | - | - | |
Other assets | ||||||
2,694 | 1,453 | 135 | 139 | 168 | - | |
Accounts payable | ||||||
1,528 | -218 | 2,621 | 186 | 590 | 33 | |
Accrued expenses and other current liabilities | ||||||
6,882 | 7,582 | 1,897 | 3,873 | 2,221 | 764 | |
Deferred revenue | ||||||
-600 | 3,933 | - | - | - | - | |
Operating lease liabilities | ||||||
-2,255 | - | - | - | - | - | |
Advance payments | ||||||
- | - | - | -127 | -26 | 153 | |
Due to related party under services agreement | ||||||
- | - | - | - | -34 | 768 | |
Other related party payables | ||||||
- | - | - | - | -3,761 | 258 | |
Deferred rent | ||||||
- | -32 | -86 | 1,277 | 246 | - | |
Other liabilities | ||||||
-523 | 1,686 | - | - | - | - | |
Net cash used in operating activities | ||||||
-107,705 | 104,648 | -57,992 | -48,558 | -22,515 | -2,399 | |
Cash flows from investing activities | ||||||
Purchases of marketable debt securities | ||||||
190,735 | 445,829 | 68,634 | 45,072 | 163,278 | - | |
Maturities of marketable debt securities | ||||||
289,994 | 179,749 | 70,224 | 72,586 | - | - | |
Sales of marketable equity securities | ||||||
6,020 | - | 780 | 23 | - | - | |
Purchases of property and equipment | ||||||
11,720 | 13,278 | 7,160 | 8,149 | 522 | - | |
Net cash provided by investing activities | ||||||
93,559 | -279,358 | -4,790 | 19,388 | -163,800 | - | |
Proceeds from exercise of stock options | ||||||
7,100 | 14,500 | 2,500 | 179 | 107 | 1 | |
Proceeds from issuance of common stock under employee stock purchase plan | ||||||
1,314 | 847 | 556 | - | - | - | |
Proceeds from public offerings of common stock, net of underwriting discounts and commissions | ||||||
- | 189,716 | 81,994 | - | - | - | |
Proceeds from initial public offering of common stock, net of transaction costs | ||||||
- | - | - | - | 145,184 | - | |
Issuance costs for public offerings of common stock | ||||||
- | 619 | 445 | 60 | - | - | |
Proceeds from related party promissory notes | ||||||
- | - | - | - | - | 2,400 | |
Net cash provided by financing activities | ||||||
8,376 | 204,443 | 84,598 | 119 | 239,310 | 2,401 | |
Net decrease in cash and cash equivalents and restricted cash | ||||||
-5,770 | 29,733 | 21,816 | -29,051 | 52,995 | 2 | |
Supplemental cash flow information | ||||||
Cash paid for income taxes | ||||||
904 | 3,443 | - | - | - | - | |
Cash paid for interest | ||||||
- | - | - | - | 7 | 164 | |
Supplemental disclosures of non-cash investing and financing activities | ||||||
Additions to property and equipment through accounts payable and accrued expenses | ||||||
1,572 | - | 254 | 1,181 | 96 | - | |
Assets acquired under financing lease obligation | ||||||
- | 5,854 | - | - | - | - | |
Deferred issuance costs for Series C convertible preferred stock in accrued expenses | ||||||
- | - | - | - | - | 157 | |
Non-cash consideration received for licenses granted | ||||||
- | - | 420 | - | - | - | |
Issuance costs for public offerings of common stock in accounts payable and accrued expenses | ||||||
- | - | - | 33 | - | - | |
Conversion of related party promissory notes into Series C convertible preferred stock | ||||||
- | - | - | - | 1,389 | - | |
Conversion of convertible preferred stock into common stock upon initial public offering | ||||||
- | - | - | - | 111,392 | - | |