| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Operating activities | ||||||||||
Net income (loss) | ||||||||||
-66,894 | -70,480 | -77,992 | -69,216 | -51,464 | - | - | - | - | - | - |
Net loss | ||||||||||
- | - | - | - | - | -90,908 | -89,027 | -98,840 | -85,973 | 37,890 | -111,547 |
Adjustments to reconcile net income (loss) to net cash used in operating activities: | ||||||||||
Stock-based compensation expense | ||||||||||
9,115 | 7,704 | 5,987 | 7,333 | 7,403 | 9,787 | 7,166 | 12,617 | 13,168 | 16,436 | 13,438 |
Gain on disposal of assets | ||||||||||
- | - | 732 | 88 | 57 | 98 | 16 | 17 | - | - | - |
Loss on sublease | ||||||||||
- | - | 495 | - | - | 9,302 | - | - | - | - | - |
Depreciation and amortization | ||||||||||
683 | 594 | 465 | 941 | 1,439 | 2,359 | 2,592 | 2,433 | 1,955 | 1,317 | 1,403 |
Non-cash restructuring charges | ||||||||||
- | - | - | 818 | - | - | - | - | - | - | - |
Net amortization and accretion of discount on short-term investments and term loan | ||||||||||
1,073 | 766 | 350 | -115 | - | - | - | - | - | - | - |
Changes in assets and liabilities: | ||||||||||
Accounts receivable, net | ||||||||||
6,034 | 4,077 | - | -203 | -5,547 | - | 5,750 | - | - | - | - |
Inventories | ||||||||||
366 | 839 | - | - | - | - | - | - | - | - | - |
Prepaid and other current assets | ||||||||||
5,673 | 1,797 | 197 | -1,097 | 917 | -722 | -1,867 | 1,624 | -38 | -19 | -960 |
Other assets | ||||||||||
-39 | -68 | -130 | -167 | -159 | -439 | -231 | -232 | -244 | -250 | -335 |
Right-of-use assets | ||||||||||
-7,118 | - | - | - | - | - | - | - | - | - | - |
Accounts payable | ||||||||||
-2,239 | 3,755 | -2,947 | 2,800 | 1,150 | -2,290 | 2,206 | 141 | 153 | -1,751 | -2,830 |
Accrued compensation | ||||||||||
-1,133 | 2,893 | 2,974 | -2,166 | 3,419 | -17 | -3,926 | -496 | 2,460 | -2,029 | 5,215 |
Accrued research and development | ||||||||||
-803 | 1,735 | -853 | 928 | 960 | 2,405 | -536 | 57 | -1,384 | -2,363 | - |
Other accrued liabilities | ||||||||||
3,122 | 269 | 2,236 | -100 | 599 | -212 | -196 | 438 | -402 | 2 | -5,311 |
Lease liability | ||||||||||
-6,725 | - | - | - | - | - | - | - | - | - | - |
Deferred revenue | ||||||||||
24,255 | 2,437 | - | - | - | - | - | - | - | - | - |
Deferred revenue | ||||||||||
- | - | - | -13,427 | 13,427 | - | - | - | - | - | - |
Deferred rent and other long term liabilities | ||||||||||
5,098 | -322 | -6,773 | -5,294 | -5,078 | -1,242 | -688 | -150 | 366 | -3,028 | 4,442 |
Net cash used in operating activities | ||||||||||
-41,510 | -58,826 | -77,557 | -75,889 | -23,413 | - | - | - | - | - | - |
Investing activities | ||||||||||
Net cash used in operating activities | ||||||||||
- | - | - | - | - | -69,753 | -86,077 | -85,209 | -69,375 | 46,743 | -102,779 |
Purchases of short-term investments | ||||||||||
145,327 | 77,996 | 116,861 | 103,053 | 151,763 | 218,594 | 308,846 | 475,398 | - | - | - |
Maturities of short-term investments | ||||||||||
123,126 | 104,066 | 96,820 | 128,650 | 196,862 | 281,705 | 365,968 | 439,724 | - | - | - |
Sales of short-term investments | ||||||||||
- | - | - | - | - | - | 16,479 | - | - | - | - |
Proceeds from disposal of assets | ||||||||||
- | - | 732 | 88 | 60 | 234 | 16 | 17 | - | - | 14 |
Purchases of available-for-sale securities | ||||||||||
- | - | - | - | - | - | - | - | 476,038 | 266,092 | 169,928 |
Maturities of available-for-sale securities | ||||||||||
- | - | - | - | - | - | - | - | 415,493 | - | - |
Maturities and sales of available-for-sale securities | ||||||||||
- | - | - | - | - | - | - | - | - | 216,249 | 139,391 |
Capital expenditures | ||||||||||
1,455 | 1,106 | 164 | 804 | 546 | 413 | 1,221 | 3,377 | 2,303 | 3,560 | 141 |
Net cash provided by (used in) investing activities | ||||||||||
-23,656 | 24,964 | -19,473 | 24,881 | 44,613 | - | - | - | - | - | - |
Financing activities | ||||||||||
Net proceeds from term loan financing | ||||||||||
9,789 | - | - | - | - | - | - | - | - | - | - |
Net cash used in investing activities | ||||||||||
- | - | - | - | - | 62,932 | 72,396 | -39,034 | -62,848 | -53,403 | -30,664 |
Net proceeds from issuances of common stock upon exercise of options and participation in Purchase Plan | ||||||||||
1,576 | 4,732 | 3,508 | 1,598 | 1,761 | 1,170 | 1,051 | - | - | - | - |
Proceeds from sale and issuance of common stock, net of offering costs | ||||||||||
- | 67,162 | 114,180 | 23,586 | 5,292 | - | - | 139,094 | 142,779 | 1,964 | 103,603 |
Payments on capital lease obligations | ||||||||||
- | - | - | - | - | - | - | - | 800 | 1,144 | 1,448 |
Net cash provided by financing activities | ||||||||||
- | - | - | - | - | 1,170 | 1,051 | 139,094 | 141,979 | 820 | 102,155 |
Net increase (decrease) in cash and cash equivalents | ||||||||||
- | - | - | - | - | -5,651 | -12,630 | 14,851 | 9,756 | -5,840 | -31,288 |
Net cash provided by financing activities | ||||||||||
11,365 | 71,894 | 117,688 | 25,184 | 7,053 | - | - | - | - | - | - |
Net increase (decrease) in cash and cash equivalents | ||||||||||
-53,801 | 38,032 | 20,658 | - | - | - | - | - | - | - | - |
Net (decrease) increase in cash and cash equivalents | ||||||||||
- | - | - | -25,824 | 28,253 | - | - | - | - | - | - |
Supplemental disclosure of cash flow information | ||||||||||
Interest paid | ||||||||||
137 | - | - | - | - | - | - | - | - | - | - |
Interest paid | ||||||||||
- | - | - | - | - | - | - | - | 21 | 84 | 176 |
Income tax refund | ||||||||||
- | - | - | - | - | - | - | - | - | 98 | 88 |
Issuance of warrant with lease amendment | ||||||||||
- | - | - | - | - | - | - | - | - | - | 616 |