| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Total revenues | ||||||||||
59,288 | 44,509 | 4,484 | 20,383 | - | - | - | - | - | - | - |
Contract revenues from collaborations | ||||||||||
- | - | - | - | 28,895 | 8,250 | 7,150 | 2,250 | 4,750 | 125,000 | 750 |
Costs and expenses: | ||||||||||
Cost of product sales | ||||||||||
906 | 287 | - | - | - | - | - | - | - | - | - |
Research and development | ||||||||||
52,885 | 46,903 | 46,269 | 63,446 | 62,825 | 67,696 | 75,328 | 78,778 | 69,350 | 64,392 | 90,743 |
Selling, general and administrative | ||||||||||
74,588 | 70,002 | 37,831 | 20,908 | - | - | - | - | - | - | - |
General and administrative | ||||||||||
- | - | - | - | 17,813 | 22,501 | 19,612 | 22,849 | 21,768 | 25,291 | 20,903 |
Restructuring charges | ||||||||||
- | - | - | 5,770 | - | - | 1,679 | - | - | - | 1,141 |
Loss on sublease | ||||||||||
- | - | - | - | - | 9,302 | - | - | - | - | - |
Total costs and expenses | ||||||||||
128,379 | 117,192 | 84,100 | 90,124 | 80,638 | 99,499 | 96,619 | 101,627 | 91,118 | 89,683 | 112,787 |
Income (Loss) from operations | ||||||||||
-69,091 | -72,683 | -79,616 | -69,741 | -51,743 | -91,249 | -89,469 | -99,377 | -86,368 | 35,317 | -112,037 |
Interest income | ||||||||||
2,532 | 2,203 | 892 | 437 | 222 | 243 | 426 | 520 | 420 | 303 | 600 |
Interest expense | ||||||||||
335 | - | - | - | - | - | - | - | 25 | 91 | 203 |
Gain on disposal of assets | ||||||||||
- | - | 732 | 88 | 57 | 98 | 16 | 17 | - | - | - |
Other income | ||||||||||
- | - | - | - | - | - | - | - | - | 2,361 | 0 |
Income (loss) before income taxes | ||||||||||
- | - | - | - | - | - | - | - | - | - | -111,640 |
Income tax benefit | ||||||||||
- | - | - | - | - | - | - | - | - | - | -93 |
Net income (loss) | ||||||||||
-66,894 | -70,480 | -77,992 | -69,216 | -51,464 | -90,908 | -89,027 | -98,840 | -85,973 | 37,890 | -111,547 |
Net income (loss) per share, basic and diluted | ||||||||||
Basic (in dollars per share) | ||||||||||
- | - | - | - | - | - | - | - | - | 0.73 | -2.73 |
Diluted (in dollars per share) | ||||||||||
- | - | - | - | - | - | - | - | - | 0.72 | -2.73 |
Weighted average shares used in computing net income (loss) per share | ||||||||||
Basic (in shares) | ||||||||||
- | - | - | - | - | - | - | - | - | 52,055 | 40,876 |
Diluted (in shares) | ||||||||||
- | - | - | - | - | - | - | - | - | 52,573 | 40,876 |
Net loss per share, basic and diluted (in dollars per share) | ||||||||||
-0.40 | -0.44 | -0.62 | -0.73 | -0.58 | -1.04 | -1.02 | -1.32 | -1.36 | - | - |
Weighted average shares used in computing net income (loss) per share, basic and diluted (in shares) | ||||||||||
167,400 | 160,529 | 126,324 | 94,387 | 88,434 | 87,662 | 87,288 | 74,967 | 63,329 | - | - |
Product sales, net | ||||||||||
Total revenues | ||||||||||
43,772 | 13,947 | - | - | - | - | - | - | - | - | - |
Contract revenues from collaborations | ||||||||||
Total revenues | ||||||||||
15,516 | 30,562 | 4,484 | 20,383 | - | - | - | - | - | - | - |