| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|
Cash Flows from Operating Activities: | |||||||||
Net loss | |||||||||
-8,635 | -14,368 | -25,294 | -9,307 | -14,384 | -18,521 | -9,499 | -11,344 | -14,022 | -2,903 |
Adjustments to reconcile net loss to net cash used in operating activities: | |||||||||
Beneficial conversion feature | |||||||||
- | - | - | - | - | - | - | 0 | 0 | 0 |
Compensatory stock | |||||||||
- | 22 | 31 | 97 | 102 | 409 | 306 | 0 | 2,108 | 0 |
Depreciation and amortization | |||||||||
40 | 48 | 42 | 32 | 27 | 28 | 37 | 45 | 50 | 41 |
Loss on sale of equipment | |||||||||
-9 | - | - | - | - | - | - | - | - | - |
Amortization of premiums and discounts on marketable securities, net | |||||||||
108 | -39 | -52 | - | - | - | - | - | - | - |
Amortization of premiums and discounts on marketable securities, net | |||||||||
- | - | - | 22 | 30 | 10 | - | - | - | - |
Stock-based compensation | |||||||||
456 | 1,228 | 1,044 | 1,409 | 1,037 | 608 | 565 | 638 | 584 | 497 |
Amortization and termination of deferred research and development arrangement | |||||||||
- | -375 | -75 | -75 | -75 | -233 | -792 | -75 | -75 | -75 |
Unrealized loss (gain) on fair value of warrants | |||||||||
-2,265 | -5,546 | 7,594 | - | - | - | - | - | - | - |
Unrealized (gain) loss on fair value of warrants | |||||||||
- | - | - | 5,529 | 3,986 | -5,180 | - | - | - | - |
Note receivable (Note 5) | |||||||||
- | - | - | - | - | - | - | 28 | -46 | 0 |
Realized losses on marketable securities | |||||||||
- | - | - | - | - | - | - | -3 | 0 | 11 |
Unrealized (gain) loss on fair value of warrants | |||||||||
- | - | - | - | - | - | 1,365 | -4,778 | 3,823 | -1,793 |
Unrealized gain on fair value of put feature on common stock | |||||||||
- | - | - | - | - | - | - | 0 | -97 | -1,915 |
Financing expense | |||||||||
- | - | 552 | 313 | 211 | 206 | 204 | 97 | 180 | 223 |
Amortization of deferred lease incentive | |||||||||
- | - | -12 | -12 | -12 | -12 | -16 | -20 | -20 | -10 |
Deferred rent | |||||||||
- | - | -10 | -12 | -8 | 7 | 25 | 8 | -24 | -38 |
Loss on impairment of intangible assets | |||||||||
- | - | - | - | - | - | - | 0 | 0 | 286 |
Changes in assets and liabilities: | |||||||||
Prepaid expenses and other assets | |||||||||
-608 | -230 | 696 | -613 | 495 | 249 | 263 | -373 | 385 | -45 |
Research tax credit receivable | |||||||||
- | - | - | - | - | - | - | 145 | -145 | 0 |
Accounts payable and accrued expenses | |||||||||
-1,886 | -81 | 1,351 | -778 | 202 | 1,525 | 81 | -635 | 1,034 | 427 |
Deferred revenue | |||||||||
1,500 | - | - | - | - | - | - | - | - | - |
Other, net | |||||||||
-3 | 36 | - | - | - | - | - | - | - | - |
Net Cash Used in Operating Activities | |||||||||
-10,277 | -18,838 | -15,420 | - | - | - | - | - | - | - |
Net Cash Used in Operating Activities | |||||||||
- | - | - | -13,227 | -17,351 | -11,041 | -7,984 | -15,530 | -6,986 | -5,146 |
Cash Flows from Investing Activities: | |||||||||
Restricted cash equivalents | |||||||||
- | - | - | - | - | -196 | -895 | 1,029 | -1,624 | 2,026 |
Purchase of equipment | |||||||||
19 | 39 | 75 | 8 | 62 | 41 | 50 | 16 | 5 | 18 |
Sale of equipment | |||||||||
5 | - | - | - | - | - | - | - | - | - |
Purchase of marketable securities | |||||||||
8,887 | - | 21,017 | 8,747 | 7,908 | 26,075 | - | 8,000 | 2,353 | 1,371 |
Redemption of marketable securities | |||||||||
12,000 | 11,950 | 11,720 | 13,240 | 17,525 | 3,260 | - | 8,500 | 75 | 4,758 |
Net Cash (Used in) Provided by Investing Activities | |||||||||
- | - | - | 4,483 | 9,554 | -22,661 | 845 | - | - | - |
Payment of licensing fees | |||||||||
- | - | - | - | - | - | - | 0 | 0 | 0 |
Net Cash Provided by (Used in) Investing Activities | |||||||||
3,098 | 11,910 | -9,372 | - | - | - | - | -545 | -660 | 1,341 |
Cash Flows from Financing Activities: | |||||||||
Issuance of common stock and units, net of issuance costs | |||||||||
7,653 | 6,872 | 16,681 | - | - | - | - | - | - | - |
Payment of deferred offering costs | |||||||||
- | 100 | - | - | - | - | - | - | - | - |
Issuance of common stock and units, net of issuance costs | |||||||||
- | - | - | 10,122 | 7,439 | 18,634 | 10,041 | 13,220 | 9,318 | 10,730 |
Proceeds from exercise of stock warrants | |||||||||
- | - | 5,354 | - | 22 | 5,947 | 2,209 | - | - | - |
Proceeds from exercise of stock options | |||||||||
- | - | 77 | - | 708 | 258 | 90 | 59 | 107 | 3 |
Net Cash Provided by Financing Activities | |||||||||
- | - | - | 10,122 | 8,170 | 24,840 | 12,340 | - | - | - |
Proceeds from exercise of stock warrants | |||||||||
- | - | - | - | - | - | - | 317 | 3,263 | 0 |
Proceeds from long-term debt | |||||||||
- | - | - | - | - | - | - | 0 | 0 | 0 |
Proceeds from research and development arrangement | |||||||||
- | - | - | - | - | - | - | 0 | 0 | 0 |
Purchase of treasury stock | |||||||||
- | - | - | - | - | - | - | 0 | 0 | 0 |
Net Cash Provided by Financing Activities | |||||||||
7,653 | 6,772 | 22,113 | - | - | - | - | 13,597 | 12,688 | 10,733 |
Net Increase (Decrease) in Cash and Cash Equivalents | |||||||||
475 | -154 | - | - | - | - | - | - | - | - |
Net Decrease in Cash and Cash Equivalents | |||||||||
- | - | -2,679 | 1,379 | 373 | -8,861 | 5,201 | -2,478 | 5,042 | 6,928 |
Supplemental Cash Flow Information | |||||||||
Operating cash flows paid for amounts included in the measurement of lease liabilities | |||||||||
197 | - | - | - | - | - | - | - | - | - |
Interest paid | |||||||||
- | - | - | - | - | - | - | 0 | 0 | 0 |
Non-cash financing and investing activties: | |||||||||
Warrants issued | |||||||||
4,735 | 4,841 | 6,738 | 4,364 | 2,966 | 3,691 | 2,564 | 2,924 | 1,980 | 4,565 |
Operating lease right-of-use assets obtained in exchange for lease obligations: | |||||||||
380 | - | - | - | - | - | - | - | - | - |
Warrant liability extinguishment from exercise of warrants | |||||||||
- | - | 8,052 | - | 9 | 10,137 | 1,737 | - | - | - |
Put feature on common stock issued | |||||||||
- | - | - | - | - | - | - | 0 | 0 | 0 |
Dilutive issuances of common stock | |||||||||
- | - | - | - | - | - | - | 0 | 0 | 2,639 |
Warrant liability extinguishment from exercise of warrants | |||||||||
- | - | - | - | - | - | - | 243 | 5,936 | 0 |
Shares withheld for net stock option exercise | |||||||||
- | - | - | - | - | 100 | - | - | - | - |
Leasehold improvement incentive | |||||||||
- | - | - | - | - | - | 54 | 0 | 0 | 100 |
Retirement of treausry stock | |||||||||
- | - | - | - | 128 | - | - | - | - | - |
Settlement of lawsuit | |||||||||
- | - | - | - | - | - | - | 0 | -43 | 0 |