| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 |
|---|---|---|---|---|---|---|---|---|
Cash flows from operating activities: | ||||||||
Net loss | ||||||||
-48,486 | -44,472 | -47,015 | -39,390 | -32,581 | -27,183 | -26,362 | -21,239 | -14,411 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||
Stock-based compensation expense | ||||||||
8,488 | 10,831 | 10,358 | 10,604 | 9,478 | 9,126 | 9,887 | 5,902 | 2,613 |
Depreciation and amortization expense | ||||||||
1,789 | 701 | 848 | 785 | 661 | 384 | 377 | 275 | 227 |
Change in fair value of preferred stock warrant liability | ||||||||
- | - | - | - | - | 0 | 426 | 1,718 | 43 |
Accretion of discount on investments | ||||||||
29 | 381 | 724 | 726 | 489 | 131 | 78 | 71 | 49 |
Non-cash interest expense | ||||||||
87 | 88 | 87 | 93 | 21 | 60 | 5 | 8 | 13 |
Changes in operating assets and liabilities: | ||||||||
Prepaid expenses and other current assets | ||||||||
-914 | -4,784 | 987 | 3,837 | -2,695 | 6,245 | 2,527 | 127 | 138 |
Operating lease, right-of-use-asset | ||||||||
-1,579 | -1,655 | -1,284 | -1,543 | -509 | - | - | - | - |
Accounts payable | ||||||||
905 | -4,221 | 7,925 | -3,775 | -966 | 2,536 | -631 | 2,581 | 452 |
Accrued expenses and other current liabilities | ||||||||
-3,954 | 2,778 | 1,113 | 5,099 | -2,487 | 1,835 | 1,038 | 1,228 | 206 |
Deferred rent | ||||||||
- | - | - | - | - | -1 | 4 | -173 | 155 |
Operating lease liabilities | ||||||||
-1,308 | -1,259 | -1,344 | -354 | 287 | - | - | - | - |
Net cash used in operating activities | ||||||||
-40,015 | -28,985 | -28,748 | -29,839 | -22,872 | -19,693 | -17,861 | -9,898 | -10,889 |
Cash flows from investing activities: | ||||||||
Purchases of property, plant and equipment | ||||||||
2,851 | 13,276 | 9,966 | 13,251 | 4,164 | 3,281 | 10,213 | 628 | 830 |
Purchases of investments | ||||||||
10,001 | 59,902 | 82,332 | 58,916 | 117,983 | 73,603 | 8,944 | 22,277 | 56,148 |
Sales and maturities of investments | ||||||||
105,000 | 83,880 | 89,101 | 25,019 | 29,155 | - | - | - | - |
Net cash provided by (used in) investing activities | ||||||||
92,148 | 10,702 | -3,197 | -47,148 | -92,992 | -46,059 | 593 | -9,195 | -56,978 |
Cash flows from financing activities: | ||||||||
Proceeds from issuance of convertible preferred stock, net of issuance costs | ||||||||
- | - | - | - | - | 0 | 0 | 0 | 100,986 |
Proceeds from issuance of common stock upon exercise of stock options | ||||||||
486 | 570 | 472 | 572 | 799 | 46 | 0 | 14 | 4 |
Net cash provided by financing activities | ||||||||
486 | 570 | 350 | 25,572 | 799 | 19,163 | 255,132 | -456 | 100,990 |
Net increase (decrease) in cash, cash equivalents and restricted cash | ||||||||
52,619 | -17,713 | -31,595 | -51,415 | -115,065 | -46,589 | 237,864 | -19,549 | 33,123 |
Supplemental cash flow information: | ||||||||
Cash paid for interest, net of interest capitalized | ||||||||
895 | 1,255 | 673 | 697 | 336 | - | - | - | 79 |
Cash paid for leases | ||||||||
2,147 | 2,181 | 2,110 | 907 | 177 | - | - | - | - |
Supplemental disclosure of non-cash investing and financing information: | ||||||||
Lease assets obtained in exchange for new operating lease liabilities | ||||||||
- | 303 | 21,552 | 0 | 27,944 | - | - | - | - |
Lease asset derecognized upon lease cancellation | ||||||||
982 | - | - | - | - | - | - | - | - |
Purchases of property, plant and equipment included in accounts payable or accrued expenses | ||||||||
923 | -2,978 | 1,334 | 109 | 4,630 | 197 | 503 | 627 | 223 |
Amounts capitalized under build-to-suit lease transaction | ||||||||
- | - | - | - | - | - | 7,739 | 5,899 | 11,019 |