| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Operating activities | ||||||||||||
Net loss | ||||||||||||
-34,164 | -32,956 | -36,003 | -42,796 | -28,974 | -25,507 | -17,686 | -14,412 | -16,459 | -10,531 | -10,016 | -6,802 | -6,360 |
Adjustments to reconcile net loss to cash used in operating activities: | ||||||||||||
Non-cash research and development license expense | ||||||||||||
- | - | - | - | - | 0 | 0 | 0 | 4,448 | - | - | - | - |
Stock-based compensation expense | ||||||||||||
5,475 | 2,924 | 3,035 | 3,272 | 2,644 | 2,023 | 1,893 | 1,516 | 958 | 709 | 871 | 434 | 264 |
Depreciation and amortization | ||||||||||||
167 | 191 | 191 | 207 | 245 | 214 | 106 | 61 | 61 | 60 | 55 | 54 | 54 |
Non-cash rent expense | ||||||||||||
-56 | -58 | 8 | 151 | 102 | 84 | 17 | -20 | -20 | -20 | -19 | -19 | -18 |
Changes in operating assets and liabilities: | ||||||||||||
Prepaid expenses and other current assets | ||||||||||||
847 | 1,786 | 544 | 727 | 3,321 | 3,526 | 1,927 | 1,414 | -581 | 917 | 904 | -237 | 305 |
Deferred issuance costs | ||||||||||||
- | - | - | - | - | - | - | - | - | -1,698 | 803 | 804 | 82 |
Due to related party | ||||||||||||
- | - | - | - | - | - | - | - | - | 0 | 0 | 0 | -105 |
Accounts payable, accrued expenses and other current liabilities | ||||||||||||
-6,673 | -536 | -1,230 | 14,347 | -2,074 | 5,729 | 655 | 1,789 | -1,220 | 1,116 | 618 | 676 | -464 |
Net cash used in operating activities | ||||||||||||
-36,098 | -32,221 | -33,605 | -25,546 | -31,378 | -20,983 | -16,942 | -12,480 | -11,651 | -7,885 | -8,417 | -6,142 | -7,016 |
Investing activities | ||||||||||||
Purchases of short-term investments | ||||||||||||
15,370 | 184,877 | 41,073 | 14,056 | 55,819 | 60,033 | 168,150 | 18,386 | 2,023 | 113,896 | 0 | 1,012 | 12,009 |
Maturities of short-term investments | ||||||||||||
44,243 | 45,750 | 82,803 | 62,516 | 80,171 | 72,703 | 32,000 | 34,833 | 22,630 | 2,500 | 6,521 | 3,995 | 3,990 |
Purchases of property and equipment | ||||||||||||
- | 0 | 259 | 2,315 | 811 | - | - | - | - | - | - | - | - |
Net cash used in investing activities | ||||||||||||
28,873 | -139,127 | 41,471 | 46,145 | 23,541 | 12,275 | -136,467 | 16,437 | 20,607 | -111,451 | 6,443 | 2,983 | -8,019 |
Financing activities | ||||||||||||
Proceeds from the exercise of stock options | ||||||||||||
383 | 611 | 434 | 498 | 21 | - | - | - | - | - | - | - | - |
Proceeds from issuance of common stock from ESPP | ||||||||||||
324 | 0 | 263 | 0 | 295 | - | - | - | - | - | 20,465 | 0 | 20,377 |
Net cash provided by financing activities | ||||||||||||
707 | 161,963 | 697 | 498 | 316 | - | - | - | - | 125,658 | 21,165 | 0 | 20,377 |
Net increase in cash, cash equivalents and restricted cash | ||||||||||||
-6,518 | -9,385 | 8,563 | 21,097 | -7,521 | -8,555 | -152,236 | 167,317 | 8,956 | 6,322 | 19,191 | -3,159 | 5,342 |