| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Operating activities | ||||||||||||
Net loss | ||||||||||||
-145,919 | -140,729 | -133,280 | -114,963 | -86,579 | -74,064 | -59,088 | -51,418 | -43,808 | -33,709 | 0 | 0 | 0 |
Adjustments to reconcile net loss to cash used in operating activities: | ||||||||||||
Non-cash research and development license expense | ||||||||||||
- | - | - | - | - | 4,448 | 0 | 0 | 0 | - | - | - | - |
Stock-based compensation expense | ||||||||||||
14,706 | 11,875 | 10,974 | 9,832 | 8,076 | 6,390 | 5,076 | 4,054 | 2,972 | 2,278 | 0 | 0 | 0 |
Depreciation and amortization | ||||||||||||
756 | 834 | 857 | 772 | 626 | 442 | 288 | 237 | 230 | 223 | 0 | 0 | 0 |
Non-cash rent expense | ||||||||||||
45 | 203 | 345 | 354 | 183 | 61 | -43 | -79 | -78 | -76 | 0 | 0 | 0 |
Changes in operating assets and liabilities: | ||||||||||||
Prepaid expenses and other current assets | ||||||||||||
3,904 | 6,378 | 8,118 | 9,501 | 10,188 | 6,286 | 3,677 | 2,654 | 1,003 | 1,889 | 0 | 0 | 0 |
Deferred issuance costs | ||||||||||||
- | - | - | - | - | - | - | - | - | -9 | 0 | 0 | 0 |
Due to related party | ||||||||||||
- | - | - | - | - | - | - | - | - | -105 | 0 | 0 | 0 |
Accounts payable, accrued expenses and other current liabilities | ||||||||||||
5,908 | 10,507 | 16,772 | 18,657 | 6,099 | 6,953 | 2,340 | 2,303 | 1,190 | 1,946 | 0 | 0 | 0 |
Net cash used in operating activities | ||||||||||||
-127,470 | -122,750 | -111,512 | -94,849 | -81,783 | -62,056 | -48,958 | -40,433 | -34,095 | -29,460 | 0 | 0 | 0 |
Investing activities | ||||||||||||
Purchases of short-term investments | ||||||||||||
255,376 | 295,825 | 170,981 | 298,058 | 302,388 | 248,592 | 302,455 | 134,305 | 116,931 | 126,917 | 0 | 0 | 0 |
Maturities of short-term investments | ||||||||||||
235,312 | 271,240 | 298,193 | 247,390 | 219,707 | 162,166 | 91,963 | 66,484 | 35,646 | 17,006 | 0 | 0 | 0 |
Purchases of property and equipment | ||||||||||||
- | 3,385 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Net cash used in investing activities | ||||||||||||
-22,638 | -27,970 | 123,432 | -54,506 | -84,214 | -87,148 | -210,874 | -67,964 | -81,418 | -110,044 | 0 | 0 | 0 |
Financing activities | ||||||||||||
Proceeds from the exercise of stock options | ||||||||||||
1,926 | 1,564 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Proceeds from issuance of common stock from ESPP | ||||||||||||
587 | 558 | 0 | 0 | 0 | - | - | - | - | - | 0 | 0 | 0 |
Net cash provided by financing activities | ||||||||||||
163,865 | 163,474 | 0 | 0 | 0 | - | - | - | - | 167,200 | 0 | 0 | 0 |
Net increase in cash, cash equivalents and restricted cash | ||||||||||||
13,757 | 12,754 | 13,584 | -147,215 | -995 | 15,482 | 30,359 | 201,786 | 31,310 | 27,696 | 0 | 0 | 0 |