| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Grant revenue | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | 352 | 457 | 717 | 976 | 946 | 0 | 0 | 0 |
Operating expenses: | ||||||||||||||||||||
Research and development | ||||||||||||||||||||
23,006 | 23,270 | 22,633 | 23,061 | 21,341 | 19,751 | 19,111 | 16,676 | 14,525 | 13,075 | 11,921 | 11,423 | 10,955 | 14,017 | 14,008 | 13,386 | 11,995 | 7,539 | 0 | 0 | 0 |
General and administrative | ||||||||||||||||||||
9,820 | 9,751 | 9,585 | 9,397 | 9,306 | 8,719 | 9,048 | 8,957 | 8,414 | 8,178 | 7,414 | 6,898 | 6,500 | 5,739 | 5,444 | 5,558 | 5,154 | 5,003 | 0 | 0 | 0 |
Total operating expenses | ||||||||||||||||||||
32,826 | 33,021 | 32,218 | 32,458 | 30,647 | 28,470 | 28,159 | 25,633 | 22,939 | 21,253 | 19,335 | 18,321 | 17,455 | 19,756 | 19,452 | 18,944 | 17,149 | 12,542 | 0 | 0 | 0 |
Loss from operations | ||||||||||||||||||||
-32,826 | -33,021 | -32,218 | -32,458 | -30,647 | -28,470 | -28,159 | -25,633 | -22,939 | -21,253 | -19,335 | -18,321 | -17,383 | -19,404 | -18,995 | -18,227 | -16,173 | -11,596 | 0 | 0 | 0 |
Other income (expense): | ||||||||||||||||||||
Interest income | ||||||||||||||||||||
1,134 | 1,254 | 1,353 | 1,353 | 1,226 | 999 | 752 | 622 | 462 | 369 | 251 | 137 | 120 | 96 | 0 | 0 | 0 | - | 0 | - | - |
Interest expense | ||||||||||||||||||||
0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Change in fair value of warrant liabilities | ||||||||||||||||||||
-5,630 | -8,212 | -8,841 | -7,150 | -6,236 | -4,617 | -8,516 | -4,072 | 3,566 | 6,795 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Interest income | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | - |
Net loss | ||||||||||||||||||||
-27,080 | -24,097 | -22,087 | -23,955 | -23,185 | -22,854 | -18,891 | -20,939 | -26,043 | -27,679 | -28,616 | -21,936 | -17,348 | -17,366 | -18,913 | -18,162 | -16,124 | -11,564 | 0 | 0 | 0 |
Unrealized gain/(loss) on marketable securities | ||||||||||||||||||||
-37 | -230 | -247 | -249 | 0 | - | 0 | 0 | - | -16 | 4 | 11 | 15 | 11 | 0 | 0 | 0 | - | 0 | 0 | - |
Comprehensive loss | ||||||||||||||||||||
-27,117 | -24,327 | -22,266 | -24,128 | -23,283 | -22,836 | -18,936 | -20,980 | -26,062 | -27,695 | -28,612 | -21,925 | -17,333 | -17,355 | -18,928 | -18,172 | -16,143 | -11,582 | 0 | 0 | 0 |
Net loss per common share: | ||||||||||||||||||||
Basic | ||||||||||||||||||||
- | - | -0.42 | - | - | - | -0.59 | - | - | - | -0.85 | - | - | - | - | - | - | - | - | - | - |
Diluted | ||||||||||||||||||||
- | - | -0.42 | - | - | - | -0.59 | - | - | - | -0.85 | - | - | - | - | - | - | - | - | - | - |
Weighted-average number of shares outstanding: | ||||||||||||||||||||
Basic | ||||||||||||||||||||
- | - | 16,459 | - | - | - | 14,841 | - | - | - | 12,696 | - | - | - | - | - | - | - | - | - | - |
Diluted | ||||||||||||||||||||
- | - | 16,459 | - | - | - | 14,841 | - | - | - | 12,696 | - | - | - | - | - | - | - | - | - | - |
Net loss per common share - basic and diluted | ||||||||||||||||||||
-0.49 | - | - | -0.28 | -0.32 | - | - | -0.29 | -0.37 | - | - | -0.93 | -0.69 | -0.13 | -0.53 | -0.62 | -1.11 | -0.68 | -0.59 | -0.39 | -0.37 |
Weighted-average number of shares outstanding - basic and diluted | ||||||||||||||||||||
16,523 | - | - | 16,443 | 16,436 | - | - | 13,179 | 12,991 | - | - | 9,517 | 9,416 | 8,465 | 7,759 | 6,923 | 5,877 | 5,802 | 5,796 | 5,796 | 5,336 |