| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Sep'15 | Jun'15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Grant and collaboration revenue | ||||||||||||||||||
6,667 | 6,677 | 926 | 926 | 913 | 903 | 27 | 53 | 0 | - | 0 | 0 | - | - | - | - | - | - | - |
Grant and collaboration revenue | ||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | 6,132 | - | 6,760 | 6,948 | 0 | 0 | 0 |
Operating expenses: | ||||||||||||||||||
Research and development | ||||||||||||||||||
50,114 | 42,743 | 37,847 | 41,628 | 43,901 | 47,687 | 51,054 | 48,673 | 45,260 | 45,165 | 42,575 | 39,092 | 34,098 | 29,702 | 24,152 | 23,445 | 0 | 0 | 0 |
General and administrative | ||||||||||||||||||
15,974 | 16,389 | 17,463 | 17,829 | 18,077 | 18,238 | 18,763 | 19,084 | 19,625 | 18,826 | 18,912 | 17,030 | 14,545 | 13,051 | 9,489 | 9,232 | 0 | 0 | 0 |
Total operating expenses | ||||||||||||||||||
66,088 | 59,132 | 55,310 | 59,457 | 61,978 | 65,925 | 69,817 | 67,757 | 64,885 | 63,991 | 61,487 | 56,122 | 48,643 | 42,753 | 33,641 | 32,677 | 0 | 0 | 0 |
Loss from operations | ||||||||||||||||||
-59,421 | -52,455 | -54,384 | -58,531 | -61,065 | -65,022 | -69,800 | -67,713 | -64,815 | -63,784 | -58,367 | -51,981 | -42,511 | -34,670 | -26,881 | -25,729 | 0 | 0 | 0 |
Investment income | ||||||||||||||||||
797 | 834 | 928 | 1,039 | 1,039 | 1,050 | 1,067 | 937 | 792 | 617 | 492 | 425 | 334 | 234 | 146 | 110 | 0 | 0 | 0 |
Loss on extinguishment of debt | ||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | 0 | - | - | - | 0 | - | - | - | - |
Foreign currency transaction (loss), net | ||||||||||||||||||
65 | -47 | -10 | 9 | 103 | 120 | 87 | 31 | 29 | -123 | -209 | -230 | -470 | -525 | 239 | 44 | 0 | 0 | 0 |
Interest expense | ||||||||||||||||||
1,396 | 1,519 | 1,579 | 1,575 | 1,540 | 1,494 | 1,458 | 1,342 | 1,256 | 1,206 | 1,169 | 1,212 | 1,243 | 1,253 | 1,265 | 1,284 | 0 | 0 | 0 |
Change in fair value of warrant liabilities | ||||||||||||||||||
0 | - | - | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Other (expense), net | ||||||||||||||||||
-1,238 | -1,306 | -68 | -62 | -59 | 10 | -5 | -8 | 0 | - | 0 | 0 | - | 4 | -91 | 0 | 0 | 0 | - |
Net loss | ||||||||||||||||||
-62,896 | -55,350 | -55,113 | -59,120 | -61,522 | -65,336 | -70,229 | -68,904 | -66,075 | -65,321 | -59,860 | -52,912 | -43,868 | -36,210 | -27,852 | -26,991 | 0 | 0 | 0 |
Stock‑based compensation expense | ||||||||||||||||||
0 | - | - | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Temporary Equity, Accretion to Redemption Value, Adjustment | ||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | 4,566 | 0 | 0 | 0 | - | - |
Accretion of redeemable convertible preferred stock | ||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 0 |
Net Income (Loss) Available to Common Stockholders, Basic | ||||||||||||||||||
- | - | -55,113 | -59,120 | - | - | 0 | 0 | 0 | - | - | - | -46,078 | -40,776 | -34,254 | -34,955 | 0 | 0 | 0 |
Other expense, net | ||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 |
Net loss | ||||||||||||||||||
-62,896 | -55,350 | -55,113 | -59,120 | -61,522 | -65,336 | -70,229 | -68,904 | -66,075 | -65,321 | -59,860 | -52,912 | -43,868 | -36,210 | -27,852 | -26,991 | 0 | 0 | 0 |
Other comprehensive loss: | ||||||||||||||||||
Foreign currency translation adjustment | ||||||||||||||||||
-48 | 34 | -16 | -53 | -150 | -153 | -114 | -73 | -26 | 78 | 167 | 183 | 396 | 504 | -384 | -154 | 0 | 0 | 0 |
Unrealized gain on securities | ||||||||||||||||||
-2 | 0 | 0 | 4 | 15 | 16 | 6 | 10 | 8 | 20 | -22 | -11 | -21 | -36 | 16 | 0 | 0 | 0 | - |
Total comprehensive loss | ||||||||||||||||||
-62,946 | -55,316 | -55,129 | -59,169 | -61,657 | -65,473 | -70,337 | -68,967 | -66,093 | -65,223 | -59,715 | -52,740 | -43,493 | -35,742 | -28,220 | -27,145 | 0 | 0 | 0 |
Net loss per share: | ||||||||||||||||||
Net loss per share attributable to common stockholders—basic and diluted (in dollars per share) | ||||||||||||||||||
-0.21 | -0.28 | -0.26 | -0.37 | -0.31 | -0.66 | -0.71 | -0.84 | -0.71 | -0.87 | -0.66 | -0.85 | -0.82 | 3.81 | -0.43 | -2.75 | -4.52 | -3.50 | -3.93 |
Weighted average common shares outstanding: | ||||||||||||||||||
Basic and diluted (in shares) | ||||||||||||||||||
94,723 | 52,483 | 46,407 | 44,855 | 38,447 | 22,452 | 22,403 | 22,355 | 22,345 | 22,329 | 22,082 | 18,814 | 18,474 | 18,370 | 18,108 | 3,322 | 2,175 | 2,159 | 2,147 |