| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Revenues: | ||||||||||
Total revenues | ||||||||||
916,713 | 654,700 | 482,250 | 418,147 | 336,802 | 286,758 | 269,264 | 210,812 | 94,778 | 107,470 | 51,965 |
Costs and expenses: | ||||||||||
Research and development | ||||||||||
719,374 | 565,309 | 456,700 | 379,308 | 294,529 | 230,743 | 218,627 | 170,297 | 163,396 | 146,410 | 119,139 |
Selling, general and administrative | ||||||||||
373,932 | 261,096 | 167,233 | 139,247 | 125,783 | 104,320 | 92,354 | 84,300 | 72,659 | 29,258 | 17,683 |
Total costs and expenses | ||||||||||
1,137,258 | 914,698 | 678,051 | 560,872 | 457,752 | 364,121 | 332,125 | 268,066 | 239,170 | 175,668 | 136,822 |
Loss from operations | ||||||||||
-220,545 | -259,998 | -195,801 | -142,725 | -120,950 | -77,363 | -62,861 | -57,254 | -144,392 | -68,198 | -84,857 |
Investment and other income (loss), net | ||||||||||
61,895 | 13,652 | 36,914 | 2,614 | 464 | 1,222 | 341 | 3,472 | -7,638 | 1,933 | 3,174 |
Loss before income taxes | ||||||||||
-158,650 | -246,346 | -158,887 | -140,111 | -120,486 | - | - | - | - | - | - |
Income tax benefit | ||||||||||
0 | -23,653 | -33,357 | 0 | 0 | - | - | - | - | - | - |
Net Income (Loss) Attributable to Parent | ||||||||||
-158,650 | -222,693 | -125,530 | -140,111 | -120,486 | -76,141 | -62,520 | -53,782 | -152,030 | -66,265 | -81,683 |
Net loss per share - basic and diluted (in dollars per share) | ||||||||||
-0.96 | -1.41 | -0.88 | -1.00 | -0.93 | -0.62 | -0.51 | -0.46 | -1.34 | -0.66 | -0.90 |
Shares used in computation of per share amounts - basic and diluted (in shares) | ||||||||||
165,498 | 157,655 | 143,174 | 140,746 | 129,184 | 123,408 | 121,575 | 117,851 | 113,098 | 101,055 | 90 |
Comprehensive loss: | ||||||||||
Net Income (Loss) Attributable to Parent | ||||||||||
-158,650 | -222,693 | -125,530 | -140,111 | -120,486 | -76,141 | -62,520 | -53,782 | -152,030 | -66,265 | -81,683 |
Other comprehensive income: | ||||||||||
Unrealized gain on securities available-for-sale, net of tax | ||||||||||
204 | 293 | 63,888 | 616 | -642 | -18 | -48 | 17 | 1,393 | -124 | - |
Foreign currency translation gain (loss) | ||||||||||
65 | -50 | 11 | 4 | -12 | 0 | 0 | - | - | - | - |
Total other comprehensive income | ||||||||||
269 | 243 | 63,899 | 620 | -654 | -18 | -48 | - | - | - | - |
Comprehensive loss | ||||||||||
-158,381 | -222,450 | -61,631 | -139,491 | -121,140 | -76,159 | -62,568 | -53,765 | -150,637 | -66,389 | - |
Product [Member] | ||||||||||
Total revenues | ||||||||||
627,977 | 476,903 | 307,562 | 265,766 | 226,052 | 178,198 | 144,665 | 138,200 | 43,241 | 0 | 0 |
Cost of sales | ||||||||||
34,882 | 66,085 | 34,768 | 28,168 | 24,476 | 17,513 | 13,759 | 11,546 | 3,115 | 0 | 0 |
Royalty [Member] | ||||||||||
Total revenues | ||||||||||
138,491 | 83,440 | 66,056 | 67,455 | 40,980 | 40,004 | 17,818 | 5,065 | 0 | 0 | - |
Cost of sales | ||||||||||
9,070 | 22,208 | 19,350 | 14,149 | 12,964 | 11,545 | 7,385 | 1,923 | 0 | 0 | - |
License and Service [Member] | ||||||||||
Total revenues | ||||||||||
150,245 | 94,357 | 108,632 | 84,926 | 69,770 | 68,556 | 106,781 | 67,547 | 51,537 | 107,470 | 51,965 |