| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Operating Activities: | ||||||||||
Net loss | ||||||||||
-95,419 | -68,889 | -54,568 | -71,658 | -40,703 | -26,417 | -26,624 | -22,264 | -35,750 | -24,854 | -18,587 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||||
Depreciation and amortization | ||||||||||
3,900 | 2,400 | 1,500 | 997 | 988 | 549 | 569 | 660 | 646 | 676 | 572 |
Amortization of discount on marketable securities | ||||||||||
4,708 | 5,829 | 673 | -221 | -827 | -1,098 | -912 | -889 | 1,576 | 1,187 | 288 |
Amortization and other changes in right-of-use assets | ||||||||||
-5,677 | - | - | - | - | - | - | - | - | - | - |
Gain on free shares | ||||||||||
488 | 0 | 0 | - | - | - | - | - | - | - | - |
Net loss on disposal of property and equipment | ||||||||||
-68 | 0 | -12 | - | - | - | - | -123 | - | - | -34 |
Stock-based compensation | ||||||||||
19,330 | 14,677 | 9,089 | 15,057 | 11,730 | 9,200 | 6,146 | 5,338 | 8,081 | 7,818 | 8,467 |
Net loss on lease termination | ||||||||||
-218 | 0 | 0 | - | - | - | - | - | - | - | - |
Change in fair value of contingent consideration liability | ||||||||||
- | - | - | - | -1,800 | 230 | 60 | - | - | - | - |
Intangible impairment | ||||||||||
- | - | - | - | 1,870 | - | - | - | - | - | - |
Benefit from income taxes | ||||||||||
- | - | - | -14 | -5,722 | - | - | - | - | - | - |
Build-to-suit leases | ||||||||||
- | 966 | 80 | -99 | - | - | - | - | - | - | - |
Other | ||||||||||
- | - | - | - | - | - | - | - | - | - | 302 |
Net changes in operating assets and liabilities: | ||||||||||
Interest receivable | ||||||||||
307 | 135 | 16 | -83 | -116 | 85 | 148 | -141 | -6 | -4 | 147 |
Accounts receivable | ||||||||||
32,236 | 1,330 | -1,629 | 2,144 | -7,847 | 7,213 | -1,008 | 3,414 | 553 | 297 | -431 |
Prepaid expenses and other assets | ||||||||||
6,660 | 2,828 | 669 | 1,112 | -376 | 258 | 480 | -14 | 13 | -97 | 96 |
Accounts payable and accrued liabilities | ||||||||||
-4,192 | -6,372 | 3,219 | -2,335 | -764 | 4,324 | 544 | -1,503 | -139 | 3,196 | -1,390 |
Accrued compensation and employee benefits | ||||||||||
4,129 | 2,604 | 2,594 | 137 | -105 | -341 | 721 | 800 | 315 | -28 | 997 |
Deferred revenues | ||||||||||
-35,693 | 99,364 | 48,984 | -5,214 | -8,380 | 13,238 | -2,190 | 11,134 | -64 | -11,733 | 3,596 |
Long-term portion of lease liabilities | ||||||||||
-1,800 | - | - | - | - | - | - | - | - | - | - |
Other non-current liabilities | ||||||||||
3,749 | 1,963 | 0 | - | - | - | - | - | - | - | - |
Net cash used in operating activities | ||||||||||
-144,402 | 36,550 | 11,179 | -65,883 | -33,720 | -5,675 | -19,482 | -8,082 | -25,895 | -23,934 | -6,137 |
Investing Activities: | ||||||||||
Proceeds from sales of marketable securities | ||||||||||
- | - | - | - | - | - | - | - | 10,139 | - | - |
Acquisition, net of cash acquired | ||||||||||
0 | 75,647 | 0 | - | 2,411 | 621 | -79 | - | - | - | - |
Purchases of marketable securities | ||||||||||
443,711 | 451,239 | 252,328 | 218,640 | 257,988 | 227,802 | 118,894 | 91,428 | 112,974 | 100,027 | 79,406 |
Maturities of marketable securities | ||||||||||
404,847 | 391,845 | 178,675 | 237,497 | 337,861 | 127,765 | 51,129 | 103,470 | 83,412 | 113,096 | 60,500 |
Purchases of property and equipment | ||||||||||
20,675 | 43,065 | 3,751 | 732 | - | - | 432 | 723 | 576 | 695 | 272 |
Purchase of additional Sangamo France shares | ||||||||||
262 | 0 | 0 | - | - | - | - | - | - | - | - |
Net cash provided by (used in) investing activities | ||||||||||
-59,801 | -178,106 | -77,404 | 18,125 | 77,462 | -100,658 | -68,118 | 11,319 | -19,999 | 12,374 | -19,178 |
Proceeds from public offering of common stock, net of issuance costs | ||||||||||
136,308 | 215,758 | 81,573 | - | - | 93,796 | 69,492 | - | 50,152 | - | - |
Taxes paid related to net share settlement of equity awards | ||||||||||
400 | 300 | 700 | 776 | 1,546 | 4,556 | 2,015 | - | 48 | - | - |
Proceeds from exercise of stock options and restricted stock units | ||||||||||
2,044 | 1,484 | 818 | 1,113 | 6,804 | 12,937 | 8,630 | 1,676 | 1,772 | 1,185 | 21,846 |
Proceeds from exercise of stock options and restricted stock units | ||||||||||
4,099 | 14,721 | 15,753 | - | - | - | - | - | - | - | - |
Claims settlement under Section 16(b) | ||||||||||
- | - | - | - | 14,452 | - | - | - | - | - | - |
Net cash provided by financing activities | ||||||||||
142,029 | 231,709 | 97,490 | 337 | 19,710 | 102,177 | 76,107 | 1,676 | 51,876 | 1,185 | 26,763 |
Effects of changes in foreign exchange rates | ||||||||||
184 | 439 | 0 | - | - | - | - | - | - | - | 302 |
Net increase (decrease) in cash, cash equivalents, and restricted cash | ||||||||||
-61,990 | 90,592 | 31,265 | -47,421 | 63,452 | -4,156 | -11,493 | 4,913 | 5,982 | -10,375 | 1,750 |
Supplemental disclosure of non-cash activities: | ||||||||||
Non-controlling interest for acquisition | ||||||||||
0 | 1,313 | 0 | - | - | - | - | - | - | - | - |
Right-of-use assets obtained in exchange for lease obligations | ||||||||||
31,291 | 0 | 0 | - | - | - | - | - | - | - | - |
Fair value of shares of common stock issued pursuant to the acquisition of Ceregene Inc. | ||||||||||
- | - | - | - | - | - | 1,200 | - | - | - | - |
Build-to-Suit Leases | ||||||||||
Capital expenditures included in unpaid liabilities | ||||||||||
0 | 2,950 | 20,793 | 3,876 | - | - | - | - | - | - | - |
Property and Equipment | ||||||||||
Capital expenditures included in unpaid liabilities | ||||||||||
2,114 | 4,953 | 1,214 | - | - | - | - | - | - | - | - |