| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 |
|---|---|---|---|---|---|---|---|---|---|
Operating activities: | |||||||||
Net loss | |||||||||
-9,355 | -8,899 | -7,147 | -3,245 | -7,831 | -6,706 | -10,058 | -4,163 | -2,378 | - |
Adjustments to reconcile net loss to net cash used in operating activities: | |||||||||
Net loss | |||||||||
- | - | - | - | - | - | - | - | - | -7,386 |
Amortization and depreciation | |||||||||
54 | 44 | 68 | 89 | 247 | 245 | 230 | 230 | 226 | 185 |
Non-cash lease expenses | |||||||||
123 | - | - | - | - | - | - | - | - | - |
Amortization of discount on debt | |||||||||
- | - | - | 7 | 10 | 0 | - | - | - | - |
Issuance of common stock for acquisition of in-process research and development | |||||||||
- | - | - | - | - | - | 0 | - | - | - |
Warrants issued to vendor | |||||||||
- | - | - | - | - | - | -4 | - | - | - |
Warrants replaced in exchange for renegotiated agreement | |||||||||
- | - | - | - | - | - | - | -429 | 0 | - |
Warrants issued to vendor | |||||||||
- | - | - | - | - | - | - | 429 | - | - |
Share-based compensation | |||||||||
376 | 380 | 489 | 574 | 654 | 720 | 803 | 462 | 715 | 571 |
Gain on settlement of liability | |||||||||
- | - | - | 390 | 0 | - | - | - | - | - |
Common stock issued for amended license agreement | |||||||||
- | - | - | - | - | - | - | - | - | 0 |
Common stock issued to former employee | |||||||||
- | - | - | - | - | - | - | - | - | 0 |
Issuance of common stock for services | |||||||||
159 | - | 5 | 52 | 232 | 256 | 82 | 21 | 26 | 171 |
(Gain) loss on disposition of office furniture | |||||||||
3 | -1 | - | - | - | - | - | - | - | - |
Change in fair value of warrant liability | |||||||||
- | - | - | -1,541 | 1,201 | -3,436 | - | - | - | - |
Common stock issued for amended license agreement | |||||||||
- | - | - | - | - | - | - | - | 400 | - |
Common stock issued to employee | |||||||||
- | - | - | - | - | - | - | 10 | 20 | - |
Charge for common stock issued for collaboration agreement | |||||||||
- | - | - | - | - | 100 | 1,500 | 0 | - | - |
Issuance of common stock for acquisition of in-process research and development | |||||||||
- | - | - | - | - | 4,000 | - | - | - | - |
Warrants issued to vendor | |||||||||
- | - | - | - | - | -4 | - | - | - | - |
Change in fair value of warrant liability | |||||||||
- | - | - | - | - | - | -3,654 | 0 | - | - |
Change in operating assets and liabilities: | |||||||||
Capitalized patent write-off | |||||||||
- | - | - | - | - | - | - | - | 88 | - |
Capitalized patent write-off | |||||||||
- | - | - | - | - | - | - | - | - | 378 |
Contracts and grants receivable | |||||||||
-182 | 275 | -280 | -778 | 1,190 | -72 | 527 | -23 | 241 | 97 |
Inventory | |||||||||
- | - | - | - | - | - | - | - | - | -42 |
Prepaid expenses and other current assets | |||||||||
452 | -105 | 128 | -109 | 71 | 37 | -5 | -55 | 8 | 46 |
Security deposit | |||||||||
0 | - | - | 0 | - | - | - | - | - | - |
Research and development incentives receivable | |||||||||
444 | - | - | - | - | - | - | - | - | - |
Income tax receivable | |||||||||
- | 416 | - | - | - | - | - | - | - | - |
Security deposit | |||||||||
- | - | -22 | - | - | - | - | - | - | - |
Income tax receivable | |||||||||
- | - | 416 | 0 | - | -750 | 750 | -574 | 322 | 251 |
Operating lease liability | |||||||||
-121 | - | - | - | - | - | - | - | - | - |
Accounts payable and accrued expenses | |||||||||
1,968 | 1,019 | 382 | -1,475 | 1,376 | - | - | - | - | - |
Accounts payable | |||||||||
- | - | - | - | - | 1,483 | 395 | -179 | -370 | 829 |
Accrued compensation | |||||||||
3 | -38 | -22 | 56 | -16 | 81 | 204 | -99 | -107 | -128 |
Total adjustments | |||||||||
1,846 | 1,655 | 636 | -1,737 | 2,444 | 4,240 | 5,602 | 1,527 | 426 | 1,655 |
Net cash used in operating activities | |||||||||
-7,509 | -7,244 | -6,510 | -4,982 | -5,386 | -2,466 | -4,456 | 2,635 | -1,951 | -5,730 |
Investing activities: | |||||||||
Acquisition of intangible assets | |||||||||
- | - | - | - | - | - | - | - | 151 | 330 |
Purchases of office furniture and equipment | |||||||||
30 | 1 | 26 | 7 | 22 | 50 | 17 | 4 | 1 | 6 |
Proceeds from sale of office furniture | |||||||||
5 | 1 | - | - | - | - | - | - | - | - |
Payments for acquisition of in-process research and development | |||||||||
- | - | - | - | - | 250 | 0 | - | - | - |
Net cash used in investing activities | |||||||||
-24 | -0 | -26 | -7 | -22 | -300 | -17 | -4 | -152 | -336 |
Financing activities: | |||||||||
Proceeds from issuance of common stock and warrants pursuant to public and private offerings | |||||||||
- | -8,636 | - | - | - | - | - | - | - | - |
Proceeds from issuance of common stock and warrants pursuant to public and private offerings | |||||||||
- | - | 5,115 | 5,278 | 0 | - | - | - | - | - |
Stock issuance costs associated with public and private offerings | |||||||||
- | -251 | 507 | 809 | - | - | - | - | - | - |
Proceeds from issuance of common stock pursuant to FBR At Market Issuance Sales Agreement | |||||||||
4,142 | - | 1,015 | 0 | - | - | - | - | - | - |
Costs associated with FBR At Market Issuance Sales Agreement | |||||||||
132 | - | 164 | 0 | - | - | - | - | - | - |
Stock issuance cost associated with equity line | |||||||||
- | - | - | 41 | - | - | - | - | - | - |
Stock issuance costs associated with equity line purchase agreement | |||||||||
- | - | - | - | 171 | 0 | - | - | - | - |
Repayment of notes payable | |||||||||
- | - | - | 300 | 0 | - | - | - | - | - |
Net proceeds from sale of units containing common stock and warrants | |||||||||
- | - | - | - | - | - | - | 0 | - | - |
Net proceeds from issuance of common stock pursuant to public financing | |||||||||
- | - | - | 3,000 | 0 | 470 | 528 | 0 | 0 | 70 |
Proceeds from issuance of common stock pursuant to the equity line | |||||||||
- | 38 | 115 | 1,712 | 3,839 | - | - | - | - | - |
Proceeds from the exercises of stock options | |||||||||
-1 | - | - | - | - | - | - | - | - | - |
Principal repayment - financing lease | |||||||||
6 | - | - | - | - | - | - | - | - | - |
Net proceeds from sale of common stock | |||||||||
- | - | - | - | - | - | - | - | - | 5,679 |
Settlement of broker fees associated with 2010 financing | |||||||||
- | - | - | - | - | - | - | - | -40 | 0 |
Proceeds from sale of common stock pursuant to equity line | |||||||||
- | - | - | - | - | - | - | - | 355 | - |
Proceeds from exercise of options and warrants | |||||||||
- | - | - | - | 1,136 | 28 | 235 | 0 | 253 | 76 |
Net proceeds from sale of units containing common stock and warrants | |||||||||
- | - | - | - | - | 1,937 | 6,210 | - | - | - |
Net cash provided by financing activities | |||||||||
4,005 | 8,423 | 5,573 | 8,840 | 4,804 | 2,436 | 6,974 | - | 649 | 5,826 |
Effect of exchange rate on cash and cash equivalents | |||||||||
-34 | -3 | - | - | - | - | - | - | - | - |
Net increase (decrease) in cash and cash equivalents | |||||||||
-3,563 | 1,174 | -963 | 3,851 | -603 | -331 | 2,499 | -2,640 | -1,455 | -240 |
Supplemental information: | |||||||||
Reclassification of warrant liability to additional paid-in capital | |||||||||
- | - | - | 892 | - | - | - | - | - | - |
Fair Value of warrants issued in Unit Offering | |||||||||
- | - | - | - | - | - | 4,827 | 0 | - | - |
Reclassification of warrant liability to additional paid-in capital | |||||||||
- | - | - | 892 | 2,557 | 1,055 | 201 | 0 | - | - |
Notes payable issued in connection with Equity Purchase Agreement | |||||||||
- | - | - | - | 282 | 0 | - | - | - | - |
Cash paid for state income taxes | |||||||||
- | - | - | 5 | - | - | - | - | - | - |
Cash paid for state income taxes | |||||||||
11 | 2 | 5 | - | 7 | 6 | 3 | 2 | 2 | 2 |
Cash paid for lease liabilities: | |||||||||
Operating lease | |||||||||
140 | - | - | - | - | - | - | - | - | - |
Financing lease | |||||||||
8 | - | - | - | - | - | - | - | - | - |
Non-cash investing and financing activities: | |||||||||
Right-of use assets and lease liabilities recognized on January 1, 2019 | |||||||||
255 | - | - | - | - | - | - | - | - | - |
Deferred issuance costs reclassified to additional-paid-in capital | |||||||||
33 | - | - | - | - | - | - | - | - | - |
Issuance of restricted common stock to vendor for website development costs | |||||||||
46 | - | - | - | - | - | - | - | - | - |
Issuance of common stock to vendor included in prepaid expenses | |||||||||
2 | - | - | - | - | - | - | - | - | - |
Shares retired | |||||||||
- | - | - | - | - | - | - | - | - | 0 |