| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Revenue: | ||||||||||
License and other revenue | ||||||||||
2,073 | 237 | 669 | - | - | - | - | - | - | - | - |
Collaboration revenue | ||||||||||
- | - | - | - | - | - | - | - | - | 27 | 1,550 |
License and other revenue | ||||||||||
- | - | - | 2,536 | 3,061 | 5,734 | 7,956 | 3,754 | 5,000 | 6 | 2,212 |
Total revenues | ||||||||||
- | - | - | 2,536 | 3,061 | 5,734 | 7,956 | 3,754 | 5,000 | 33 | 3,762 |
Operating expenses: | ||||||||||
Research and development | ||||||||||
15,412 | 14,615 | 21,540 | 22,881 | 23,701 | 27,665 | 28,891 | 29,185 | 22,563 | 14,433 | 13,247 |
General and administrative | ||||||||||
9,949 | 11,332 | 13,548 | 16,115 | 18,662 | 23,112 | 10,838 | 9,175 | 8,303 | 7,005 | 7,748 |
Restructuring charges | ||||||||||
- | - | - | - | - | - | - | - | - | - | 1,916 |
Total operating expenses | ||||||||||
25,361 | 25,947 | 35,088 | 38,996 | 42,363 | 50,777 | 39,729 | 38,360 | 30,866 | 21,438 | 22,911 |
Loss from operations | ||||||||||
-23,288 | -25,710 | -34,419 | -36,460 | -39,302 | -45,043 | -31,773 | -34,606 | -25,866 | -21,405 | -19,149 |
Interest expense | ||||||||||
514 | 1,154 | 1,396 | 1,721 | 939 | 1,719 | 2,917 | 1,855 | 259 | - | - |
Other income, net | ||||||||||
472 | 249 | 357 | 158 | 3,565 | 3,760 | 92 | -7,490 | 5,984 | -3,182 | -21,077 |
Net loss | ||||||||||
-23,330 | -26,615 | -35,458 | -38,023 | -36,676 | -43,002 | -34,598 | -43,951 | -20,141 | -24,587 | -40,226 |
Unrealized loss on available-for-sale securities | ||||||||||
1 | 7 | 15 | - | - | - | - | - | - | - | - |
Unrealized gain on available-for-sale securities | ||||||||||
- | - | - | -11 | -4 | -4 | -41 | 19 | 34 | -15 | -8 |
Comprehensive loss | ||||||||||
-23,329 | -26,608 | -35,443 | -38,034 | -36,680 | -43,006 | -34,639 | -43,932 | -20,107 | -24,602 | -40,234 |
Deemed distribution to preferred stockholders | ||||||||||
- | - | - | - | - | - | - | - | - | - | 27,563 |
Basic | ||||||||||
- | - | - | -38,023 | -36,676 | -43,002 | -34,598 | -43,951 | - | - | -67,789 |
Diluted | ||||||||||
- | - | - | -38,023 | -36,676 | -46,894 | -34,598 | -43,951 | - | - | - |
Basic | ||||||||||
- | - | - | 15,688 | 12,156 | 10,010 | 52,249 | 48,146 | - | - | - |
Diluted | ||||||||||
- | - | - | 15,688 | 12,156 | 10,252 | 52,249 | 48,146 | - | - | - |
Basic | ||||||||||
- | - | - | -2.42 | -3.02 | -4.30 | -0.66 | -0.91 | - | - | - |
Diluted | ||||||||||
- | - | - | -2.42 | -3.02 | -4.57 | -0.66 | -0.91 | - | - | - |
Basic and diluted loss per common share: | ||||||||||
Net loss | ||||||||||
-23,330 | -26,615 | -35,458 | -38,023 | -36,676 | - | -34,598 | -43,951 | -20,141 | -24,587 | -40,226 |
Shares used in computing net loss per common share | ||||||||||
87,129 | 35,582 | 24,516 | - | - | - | - | - | 46,412 | 24,860 | - |
Net loss per common share | ||||||||||
-0.27 | -0.75 | -1.45 | - | - | - | - | - | -0.43 | -0.99 | - |
Basic and diluted loss attributable to common stockholders per common share | ||||||||||
- | - | - | - | - | - | - | - | - | - | -11.80 |