| Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 |
|---|---|---|---|---|---|---|
Cash flows used in operating activities | ||||||
Net loss | ||||||
-6,778 | -8,628 | -11,164 | -14,197 | -30,712 | -11,149 | -21,194 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||
Stock-based compensation | ||||||
860 | 1,712 | 425 | 776 | 2,091 | 1,174 | 676 |
Accretion of debt discount | ||||||
149 | 44 | 81 | 137 | 188 | 380 | 509 |
Amortization of intangible assets | ||||||
- | - | - | - | - | - | 149 |
Amortization of promissory note issuance costs | ||||||
56 | 17 | - | 0 | 38 | 108 | 155 |
Depreciation of property and equipment | ||||||
2 | 4 | 12 | 20 | 47 | 84 | 82 |
Amortization of premium/discount on securities available-for-sale | ||||||
51 | -116 | -20 | -5 | -39 | -9 | - |
Impairment loss | ||||||
- | - | - | - | - | - | 176 |
Change in fair value warrant liability | ||||||
-8,690 | -3,307 | 330 | 0 | -49 | -689 | - |
Noncash portion of loss on early extinguishment of debt | ||||||
- | - | 159 | 0 | 0 | - | - |
Payment of original issue discount | ||||||
- | - | 124 | 0 | 0 | - | - |
Foreign exchange transaction loss | ||||||
-8 | -6 | - | -6 | -1 | -229 | 148 |
Other | ||||||
- | - | - | - | -3 | -2 | - |
Changes in operating assets and liabilities: | ||||||
Other | ||||||
- | - | - | - | - | - | 1 |
Other receivables | ||||||
- | - | - | -8 | -33 | -23 | -172 |
Prepaid expenses and other current assets | ||||||
-373 | 37 | 499 | - | - | - | - |
Prepaid expenses | ||||||
- | - | - | -2,358 | -734 | 3,112 | 162 |
Other long-term assets | ||||||
- | - | - | - | - | -25 | 15 |
Accounts payable | ||||||
963 | 374 | -446 | -1,728 | 1,171 | -305 | -1,006 |
Accrued expenses | ||||||
-349 | -269 | 1,195 | -1,742 | 186 | 15 | 1,769 |
Net cash used in operating activities | ||||||
-13,457 | -9,968 | -10,329 | -14,357 | - | - | - |
Net cash used in operating activities | ||||||
- | - | - | - | -26,230 | -13,206 | -18,836 |
Cash flows (used in) provided by investing activities | ||||||
Purchases of property and equipment | ||||||
4 | 3 | - | 0 | 9 | 3 | 26 |
Proceeds from the disposal of property and equipment | ||||||
- | - | - | - | - | 1 | - |
Maturities of securities available-for-sale | ||||||
11,887 | 22,161 | 2,750 | 26,169 | 43,201 | 0 | - |
Purchases of securities available-for-sale | ||||||
3,616 | 15,835 | 16,471 | 10,103 | 28,501 | 33,320 | - |
Net cash (used in) provided by investing activities | ||||||
8,267 | 6,323 | -13,721 | 16,066 | 14,691 | -33,322 | -26 |
Cash flows provided by financing activities | ||||||
Proceeds from the issuance of common shares, pre-funded warrants and common share purchase warrants, net of paid issuance costs | ||||||
102 | - | 33,534 | 785 | 1,891 | - | - |
Proceeds from the exercise of warrants | ||||||
- | - | 2,486 | 0 | 0 | - | - |
Proceeds from exercise of stock options | ||||||
- | 2 | 92 | 0 | 0 | - | - |
Issuance of common shares under stock purchase agreement, net of issuance cost | ||||||
- | - | - | - | - | 0 | 8,285 |
Issuance of common shares from public offering, net of issuance cost | ||||||
- | - | - | - | - | 57,253 | -211 |
Payment of offering costs related to the establishment of the Controlled Equity Sales Agreement | ||||||
- | - | - | - | 53 | 0 | - |
Proceeds from the issuance of the Silicon Valley Bank promissory note, net of issuance costs | ||||||
- | 6,930 | - | 0 | 2,362 | 0 | - |
Principal payments on note payable | ||||||
- | - | 5,141 | 735 | 3,361 | 5,524 | 3,190 |
Net cash provided by financing activities | ||||||
102 | 6,932 | 30,971 | 50 | 839 | 51,729 | 4,884 |
Effect of exchange rate changes on cash and cash equivalents | ||||||
-1 | - | -2 | -1 | -16 | -83 | 289 |
Net decrease in cash and cash equivalents | ||||||
-5,089 | 3,287 | 6,919 | 1,758 | -10,716 | 5,118 | -13,689 |
Cash paid for interest | ||||||
479 | 105 | 334 | 559 | 495 | 884 | 1,350 |
Cash paid for taxes | ||||||
- | - | - | - | - | 500 | - |
Supplemental disclosures of non-cash investing and financing activities: | ||||||
Valuation of warrant liability upon issuance of purchase warrants | ||||||
- | - | 18,747 | 0 | 0 | 1,572 | - |
Reclassification of fair value of warrant liability to equity as a result of the amendment of the underlying common share purchase warrants | ||||||
- | - | - | - | 834 | - | - |
Value of warrants issued in connection with the Silicon Valley Bank promissory note | ||||||
- | 185 | - | 0 | 124 | 0 | - |
Valuation of exercised warrants reclassified from warrant liability to contributed surplus | ||||||
- | - | 5,681 | 0 | 0 | 0 | - |
Change in the fair value of stock-based compensation liability recorded to contributed surplus | ||||||
- | -57 | -111 | 146 | -180 | 39 | - |
Unrealized loss on securities available-for sale | ||||||
3 | 2 | - | - | - | - | - |
Unpaid issuance costs included in accounts payable | ||||||
102 | - | - | - | - | - | - |
Unrealized loss on securities available-for sale | ||||||
- | - | - | 0 | -1 | 1 | - |
Deferred financing cost incurred but not yet paid | ||||||
- | - | - | - | - | 53 | 725 |