| Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 | Dec'14 | Sep'14 | Jun'14 | Mar'14 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cash flows used in operating activities | ||||||||||||||||||||||
Net loss | ||||||||||||||||||||||
37 | -1,876 | -5,809 | -6,778 | -16,262 | -16,044 | -9,338 | -8,628 | -5,211 | -6,840 | -11,541 | -11,164 | -13,116 | -12,488 | -12,135 | -14,197 | -16,976 | -21,546 | -26,556 | -30,712 | 0 | 0 | 0 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||||||||||||||||
Stock-based compensation | ||||||||||||||||||||||
787 | 853 | 854 | 860 | 1,061 | 1,266 | 1,541 | 1,712 | 1,487 | 1,107 | 737 | 425 | 405 | 507 | 639 | 776 | 990 | 1,392 | 1,709 | 2,091 | 0 | 0 | 0 |
Accretion of debt discount | ||||||||||||||||||||||
137 | 144 | 147 | 149 | 150 | 119 | 81 | 44 | 7 | 19 | 49 | 81 | 114 | 130 | 135 | 137 | 137 | 134 | 154 | 188 | 0 | 0 | 0 |
Amortization of promissory note issuance costs | ||||||||||||||||||||||
52 | 53 | 56 | 56 | 57 | 46 | 31 | 17 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | 38 | 0 | 0 | 0 |
Depreciation and amortization | ||||||||||||||||||||||
0 | 0 | 0 | - | - | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Depreciation of property and equipment | ||||||||||||||||||||||
- | - | - | - | - | - | - | 4 | 4 | 6 | 9 | 12 | 17 | 19 | 20 | 20 | 20 | 20 | 31 | 47 | 0 | 0 | 0 |
Amortization of premium/discount on securities available-for-sale | ||||||||||||||||||||||
34 | 32 | 39 | 51 | 47 | 11 | -48 | -116 | -139 | -112 | -67 | -20 | -2 | -4 | -3 | -5 | -8 | -10 | -24 | -39 | 0 | 0 | 0 |
Change in fair value warrant liability | ||||||||||||||||||||||
-10,652 | -9,524 | -7,887 | -8,690 | 455 | -63 | -4,749 | -3,307 | -5,544 | -4,523 | 416 | 330 | 0 | 0 | 0 | - | - | - | - | -49 | 0 | 0 | 0 |
Foreign exchange transaction loss | ||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -6 | -33 | -10 | 0 | -1 | 0 | 0 | 0 |
Other | ||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -6 | -3 | 0 | 0 | 0 |
Other receivables | ||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | 86 | - | -6 | -6 | -16 | -8 | -1 | -9 | -38 | -33 | 0 | 0 | 0 |
Prepaid expenses and other current assets | ||||||||||||||||||||||
-177 | -749 | -598 | -373 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Prepaid expenses | ||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | 0 | - | - | - | -2,076 | -2,358 | -1,596 | -716 | -1,354 | -734 | 0 | 0 | 0 |
Accounts payable | ||||||||||||||||||||||
-63 | -714 | -338 | 963 | -313 | 769 | 773 | 374 | 459 | 302 | -32 | -446 | -516 | -565 | -1,148 | -1,728 | -3,114 | -2,895 | -2,870 | 1,171 | 0 | 0 | 0 |
Accrued expenses | ||||||||||||||||||||||
-1,352 | -1,508 | -664 | -349 | 608 | 1,501 | 1,054 | -269 | -90 | 480 | 145 | 1,195 | 327 | -988 | -840 | -1,742 | -1,659 | -131 | 373 | 186 | 0 | 0 | 0 |
Operating lease liability | ||||||||||||||||||||||
0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Net cash used in operating activities | ||||||||||||||||||||||
-10,543 | -11,844 | -13,073 | -13,457 | -13,991 | -12,448 | -10,526 | -9,968 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Net cash used in operating activities | ||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | 0 | -11,244 | - | -18,964 | -22,281 | -25,740 | -26,230 | 0 | 0 | 0 |
Cash flows (used in) provided by investing activities | ||||||||||||||||||||||
Purchases of property and equipment | ||||||||||||||||||||||
- | - | - | 4 | 4 | 5 | 5 | 3 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Maturities of securities available-for-sale | ||||||||||||||||||||||
5,100 | 6,150 | 7,437 | 11,887 | 18,812 | 25,157 | 24,911 | 22,161 | 12,736 | 4,291 | 2,600 | 2,750 | 7,250 | 10,550 | 16,549 | 26,169 | 26,569 | 31,169 | 39,871 | 43,201 | 0 | 0 | 0 |
Purchases of securities available-for-sale | ||||||||||||||||||||||
4,617 | 2,573 | 2,969 | 3,616 | 9,233 | 12,516 | 13,918 | 15,835 | 24,701 | 21,621 | 19,229 | 16,471 | 2,504 | 5,329 | 7,755 | 10,103 | 18,561 | 22,029 | 27,300 | 28,501 | 0 | 0 | 0 |
Net cash (used in) provided by investing activities | ||||||||||||||||||||||
483 | 3,576 | 4,466 | 8,267 | 9,575 | 12,636 | 10,988 | 6,323 | -11,968 | -17,331 | -16,629 | -13,721 | 4,746 | 5,221 | 8,794 | 16,066 | 8,006 | 9,134 | 12,562 | 14,691 | 0 | 0 | 0 |
Cash flows provided by financing activities | ||||||||||||||||||||||
Proceeds from exercise of stock options | ||||||||||||||||||||||
- | - | - | - | - | - | - | 2 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Payment of offering costs related to the establishment of the Controlled Equity Sales Agreement | ||||||||||||||||||||||
0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 53 | 0 | 0 | 0 |
Principal payments on note payable | ||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | 5,141 | 5,585 | 1,656 | 1,190 | 735 | 291 | 0 | 1,700 | 3,361 | 0 | 0 | 0 |
Net cash provided by financing activities | ||||||||||||||||||||||
0 | 0 | 0 | - | - | - | - | 6,932 | 6,824 | 26,281 | 31,428 | 30,971 | 31,443 | 4,742 | -405 | 50 | -291 | -93 | 2,553 | 839 | 0 | 0 | 0 |
Effect of exchange rate changes on cash and cash equivalents | ||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | -2 | 12 | 8 | 7 | -1 | -17 | -21 | -13 | -16 | 0 | 0 | 0 |
Net decrease in cash and cash equivalents | ||||||||||||||||||||||
-7,797 | -8,969 | -8,608 | -5,089 | -4,438 | 7,117 | 7,392 | 3,287 | -14,569 | -1,514 | 3,748 | 6,919 | 26,147 | 344 | -2,848 | 1,758 | -11,266 | -13,261 | -10,638 | -10,716 | 0 | 0 | 0 |
Valuation of exercised warrants reclassified from warrant liability to contributed surplus | ||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 0 | 0 | 0 |
Change in the fair value of stock-based compensation liability recorded to contributed surplus | ||||||||||||||||||||||
- | - | - | - | - | - | - | -57 | -195 | -102 | -98 | -111 | 153 | 49 | 88 | 146 | -233 | -267 | -149 | -180 | 0 | 0 | 0 |