| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 |
|---|---|---|---|---|---|---|
Cash flows from operating activities | ||||||
Net loss | ||||||
-76,817 | -85,024 | -67,828 | -38,303 | -37,243 | -28,829 | -24,196 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||
Depreciation and amortization expense | ||||||
93 | 56 | 14 | - | - | - | - |
Depreciation | ||||||
- | - | - | 80 | 153 | 153 | 76 |
Stock-based compensation expense | ||||||
26,175 | 13,942 | 8,618 | 7,431 | 5,162 | 4,436 | 4,847 |
Stock award - in-licensing | ||||||
500 | - | - | - | - | - | - |
Employee Stock Purchase Plan compensation expense | ||||||
266 | 84 | 68 | 73 | 55 | - | - |
Accretion of premium paid on marketable securities | ||||||
-995 | -96 | 140 | 221 | 277 | 249 | - |
Non-cash lease expense | ||||||
974 | - | - | - | - | - | - |
Unrealized foreign exchange loss | ||||||
15 | - | - | - | - | - | - |
Net loss on sale of marketable securities | ||||||
-2 | -7 | -6 | 11 | 1 | 3 | - |
Income tax benefit from other comprehensive income | ||||||
- | - | - | 25 | - | - | - |
Non-cash interest expense | ||||||
- | - | - | - | - | - | 94 |
Mark-to-market of put option liability | ||||||
- | - | - | - | - | - | 30 |
Beneficial conversion of convertible interest | ||||||
- | - | - | - | - | - | -422 |
Changes in operating assets and liabilities: | ||||||
Accounts receivable, net | ||||||
15,103 | - | - | - | - | - | - |
Inventories, net | ||||||
946 | - | - | - | - | - | - |
Related party receivable | ||||||
- | - | - | - | - | -199 | 199 |
Other assets | ||||||
96 | - | - | 212 | - | - | - |
Prepaid expenses and other current assets | ||||||
1,506 | 2,483 | 178 | -361 | -984 | 1,343 | -6 |
Accounts payable and accrued expenses | ||||||
797 | 1,410 | 10,457 | 651 | 4,981 | -539 | 2,218 |
Operating lease liabilities | ||||||
-1,013 | - | - | - | - | - | - |
Other current liabilities | ||||||
0 | -37 | 25 | 71 | - | - | - |
Deferred grant income | ||||||
- | - | -898 | -541 | 8 | -35 | 643 |
Other liabilities | ||||||
-6 | -41 | -45 | 110 | 31 | - | - |
Net cash used in operating activities | ||||||
-67,689 | -72,181 | -49,618 | -30,092 | -25,589 | -25,713 | -16,118 |
Cash flows from investing activities | ||||||
Purchase of fixed assets | ||||||
62 | 112 | 128 | 7 | 19 | - | 460 |
Purchase of short and long-term investments | ||||||
218,884 | 63,201 | 61,893 | 26,464 | 105,565 | 16,246 | 40,248 |
Sale and maturities of short and long-term investments | ||||||
119,755 | 74,111 | 57,584 | 53,148 | 54,662 | 22,631 | - |
Net cash provided by (used in) investing activities | ||||||
-99,191 | 10,796 | -4,437 | 26,676 | -50,922 | 6,384 | -40,708 |
Cash flows from financing activities | ||||||
Principal payments on finance lease liabilities | ||||||
- | 5 | - | - | - | - | - |
Proceeds from issuance of common stock from follow-on public offering, net | ||||||
168,444 | 63,908 | 48,242 | - | 64,106 | - | 97,708 |
Proceeds from issuance of common stock from ESPP | ||||||
414 | 194 | 150 | 91 | 49 | - | - |
Proceeds from exercise of stock options | ||||||
2,140 | 1,583 | 141 | 264 | 725 | 135 | 1,293 |
Proceeds from exercise of warrants | ||||||
- | 352 | - | - | - | - | - |
Net cash provided by financing activities | ||||||
170,999 | 66,033 | 48,534 | 355 | 64,880 | 135 | 99,002 |
Net increase in cash and cash equivalents | ||||||
4,118 | 4,648 | -5,520 | -3,060 | -11,631 | -19,193 | 42,175 |