| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 | Dec'14 | Sep'14 | Jun'14 | Mar'14 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cash flows from operating activities | ||||||||||||||||||||||||
Net loss | ||||||||||||||||||||||||
-70,703 | -76,817 | -85,772 | -91,927 | -94,014 | -85,024 | -80,138 | -75,150 | -71,679 | -67,828 | -56,088 | -49,955 | -43,820 | -38,303 | -38,473 | -37,783 | -38,614 | -37,243 | -33,996 | -31,648 | -27,507 | -28,829 | 0 | 0 | 0 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||||||||||||||||||
Depreciation and amortization expense | ||||||||||||||||||||||||
0 | - | - | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Depreciation | ||||||||||||||||||||||||
- | - | - | - | - | - | - | 0 | 25 | - | 3 | 3 | 42 | 80 | 118 | 155 | 154 | 153 | 153 | 153 | 153 | 153 | 0 | 0 | 0 |
Stock-based compensation expense | ||||||||||||||||||||||||
23,429 | 26,175 | 26,214 | 23,848 | 18,942 | 13,942 | 11,122 | 10,301 | 9,065 | 8,618 | 7,942 | 8,411 | 7,881 | 7,431 | 6,344 | 5,378 | 5,230 | 5,162 | 5,610 | 5,147 | 4,635 | 4,436 | 0 | 0 | 0 |
Stock award - in-licensing | ||||||||||||||||||||||||
- | 500 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Employee Stock Purchase Plan compensation expense | ||||||||||||||||||||||||
297 | 266 | 220 | 129 | 90 | 84 | 71 | 68 | 69 | 68 | 68 | 69 | 69 | 73 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Accretion of premium paid on marketable securities | ||||||||||||||||||||||||
-1,000 | -995 | -698 | -521 | -189 | -96 | -34 | 52 | 104 | 140 | 172 | 189 | 221 | 221 | 286 | 300 | 299 | 277 | 0 | 0 | 0 | - | - | - | - |
Non-cash lease expense | ||||||||||||||||||||||||
0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Unrealized foreign exchange loss | ||||||||||||||||||||||||
0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Net loss on sale of marketable securities | ||||||||||||||||||||||||
- | -2 | -7 | -7 | -7 | -7 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | 1 | 0 | 0 | 0 | - | - | - | - |
Changes in operating assets and liabilities: | ||||||||||||||||||||||||
Accounts receivable, net | ||||||||||||||||||||||||
6,243 | 15,103 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Inventories, net | ||||||||||||||||||||||||
313 | 946 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Other assets | ||||||||||||||||||||||||
0 | - | - | - | - | - | - | - | - | - | - | - | - | 212 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Prepaid expenses and other current assets | ||||||||||||||||||||||||
1,157 | 1,506 | 550 | 1,374 | 2,023 | 2,483 | 1,397 | 1,750 | 581 | 178 | 74 | -264 | -970 | -361 | -347 | -1,488 | -288 | -984 | 134 | 563 | 172 | 1,343 | 0 | 0 | 0 |
Operating right-of-use assets | ||||||||||||||||||||||||
- | - | - | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Accounts payable and accrued expenses | ||||||||||||||||||||||||
-3,584 | 797 | 4,174 | 7,570 | 5,924 | 1,410 | 2,873 | 4,655 | 6,953 | 10,457 | 6,429 | 5,816 | 4,833 | 651 | 1,928 | 2,684 | 4,714 | 4,981 | 2,393 | 1,611 | -1,663 | -539 | 0 | 0 | 0 |
Operating lease liabilities | ||||||||||||||||||||||||
-3,153 | -1,013 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Deferred grant income | ||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | -898 | -1,197 | -1,197 | -635 | -541 | -447 | -119 | -75 | 8 | 393 | 292 | -85 | -35 | 0 | 0 | 0 |
Other liabilities | ||||||||||||||||||||||||
111 | -6 | -21 | -116 | -138 | -41 | -48 | -58 | -51 | -45 | -38 | 67 | 124 | 110 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Net cash used in operating activities | ||||||||||||||||||||||||
-59,326 | -67,689 | -74,935 | -80,454 | -77,233 | -72,181 | -67,464 | -62,107 | -56,657 | -49,618 | -42,671 | -36,258 | -30,277 | -30,092 | -29,896 | -28,020 | -28,139 | -25,589 | -25,326 | -24,810 | -24,185 | -25,713 | 0 | 0 | 0 |
Cash flows from investing activities | ||||||||||||||||||||||||
Purchase of fixed assets | ||||||||||||||||||||||||
2 | 62 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | 7 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Purchase of short and long-term investments | ||||||||||||||||||||||||
147,432 | 218,884 | 185,061 | 98,975 | 100,012 | 63,201 | 64,246 | 62,288 | 103,327 | 61,893 | 59,667 | 66,219 | 26,889 | 26,464 | 39,675 | 46,056 | 88,069 | 105,565 | 88,084 | 73,633 | 25,376 | 16,246 | 0 | 0 | 0 |
Sale and maturities of short and long-term investments | ||||||||||||||||||||||||
127,125 | 119,755 | 105,550 | 92,970 | 90,989 | 74,111 | 67,016 | 66,692 | 60,810 | 57,584 | 55,006 | 49,693 | 61,077 | 53,148 | 56,849 | 72,415 | 55,773 | 54,662 | 0 | 0 | 0 | - | - | - | - |
Net cash provided by (used in) investing activities | ||||||||||||||||||||||||
-20,309 | -99,191 | -79,603 | -6,191 | -9,210 | 10,796 | 2,633 | 4,300 | -42,645 | -4,437 | -4,746 | -16,551 | 34,183 | 26,676 | 17,146 | 26,332 | -32,318 | -50,922 | -46,371 | -46,944 | 57 | 6,384 | 0 | 0 | 0 |
Cash flows from financing activities | ||||||||||||||||||||||||
Proceeds from issuance of common stock from follow-on public offering, net | ||||||||||||||||||||||||
- | 168,444 | 168,349 | 86,158 | 94,476 | 63,908 | 64,003 | 63,968 | 55,650 | 48,242 | 0 | 0 | 0 | - | - | - | - | 64,106 | 0 | 0 | 0 | - | - | - | - |
Proceeds from issuance of common stock from ESPP | ||||||||||||||||||||||||
502 | 414 | 350 | 205 | 247 | 194 | 172 | 170 | 169 | 150 | 153 | 139 | 95 | 91 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Proceeds from exercise of stock options | ||||||||||||||||||||||||
2,149 | 2,140 | 1,542 | 343 | 509 | 1,583 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | 725 | 388 | 420 | 453 | 135 | 0 | 0 | 0 |
Proceeds from exercise of warrants | ||||||||||||||||||||||||
- | - | - | - | - | 352 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Net cash provided by financing activities | ||||||||||||||||||||||||
84,878 | 170,999 | 170,239 | 86,702 | 95,227 | 66,033 | 66,243 | 66,166 | 57,404 | 48,534 | 48,555 | 48,590 | 48,601 | 355 | 591 | 524 | 447 | 64,880 | 64,494 | 64,527 | 64,559 | 135 | 0 | 0 | 0 |
Effect of exchange rate changes on cash and cash equivalents | ||||||||||||||||||||||||
0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Net increase in cash and cash equivalents | ||||||||||||||||||||||||
5,216 | 4,118 | 15,700 | 56 | 8,783 | 4,648 | 1,412 | 8,359 | -41,898 | -5,520 | 1,137 | -4,219 | 52,507 | -3,060 | -12,158 | -1,164 | -60,009 | -11,631 | -7,202 | -7,227 | 40,431 | -19,193 | 0 | 0 | 0 |