| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 |
|---|---|---|---|---|---|---|
Cash flows from operating activities: | ||||||
Net loss | ||||||
-51,373 | -48,435 | -40,377 | - | - | - | - |
Net loss | ||||||
- | - | - | -20,954 | -24,983 | -15,834 | -6,436 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||
Depreciation | ||||||
2,702 | 2,421 | 2,310 | 692 | - | - | - |
Loss on disposal of property and equipment | ||||||
- | -8 | -5 | -4 | - | - | - |
Loss on disposal of assets | ||||||
- | - | - | - | 0 | 0 | - |
Restructuring charges | ||||||
- | - | - | - | 0 | 0 | - |
Depreciation and amortization | ||||||
- | - | - | - | 54 | 35 | 36 |
Equity-based compensation expense | ||||||
4,134 | 4,317 | 2,652 | 369 | 985 | 408 | 163 |
Common shares issued for license acquisition | ||||||
- | - | 1,750 | - | 0 | 4 | - |
Accretion/amortization of investment securities | ||||||
1,282 | 1,401 | 6 | - | 0 | 0 | - |
Reduction in carrying amount of operating lease right-of-use asset | ||||||
1,370 | - | - | - | - | - | - |
Change in fair value of option liability | ||||||
- | - | - | - | - | - | 339 |
Changes in operating assets and liabilities: | ||||||
Prepaid expenses and other current assets | ||||||
12,263 | 45 | 87 | 1,341 | - | - | - |
Prepaid research and development, net of current portion | ||||||
-16,381 | - | - | - | - | - | - |
Other assets | ||||||
- | -168 | -192 | 84 | - | - | - |
Accounts payable and accrued expenses | ||||||
-935 | -257 | 4,071 | 1,329 | - | - | - |
Deferred revenue | ||||||
276 | -520 | -444 | - | - | - | - |
Deferred revenue | ||||||
- | - | - | -444 | - | - | - |
Deferred rent | ||||||
- | 1,274 | -1,121 | 21 | - | - | - |
Operating lease liabilities | ||||||
-1,716 | - | - | - | - | - | - |
Grant reimbursement and other receivables | ||||||
- | - | - | - | -119 | -40 | -121 |
Prepaid expenses and other current assets | ||||||
- | - | - | - | 650 | 99 | -2 |
Deferred offering costs | ||||||
- | - | - | - | 0 | -105 | 197 |
Other noncurrent assets | ||||||
- | - | - | - | 0 | -17 | 17 |
Accounts payable | ||||||
- | - | - | - | 2,816 | 189 | -132 |
Accrued expenses | ||||||
- | - | - | - | 524 | 1,165 | 303 |
Net cash used in operating activities | ||||||
-75,468 | -42,470 | -31,055 | - | -21,135 | -13,970 | - |
Cash flows from investing activities: | ||||||
Net cash used in operating activities | ||||||
- | - | - | -20,408 | - | - | -6,496 |
Net assets acquired in reverse merger, net of transaction costs | ||||||
- | - | -40,433 | - | - | - | - |
Purchases of marketable securities | ||||||
145,418 | 172,887 | 51,438 | - | - | - | - |
Purchases of marketable securities | ||||||
- | - | - | - | 0 | 0 | - |
Proceeds from maturity of marketable securities | ||||||
157,465 | 91,340 | 22,850 | - | 0 | 0 | - |
Changes in restricted cash | ||||||
- | - | - | - | 0 | 0 | - |
Proceeds from sale of property and equipment | ||||||
- | - | 11 | 8 | - | - | - |
Purchases of property and equipment | ||||||
1,251 | 5,654 | 2,578 | 1,841 | 251 | 102 | 7 |
Net cash provided by investing activities | ||||||
10,796 | -87,201 | 9,278 | - | - | - | - |
Cash flows from financing activities: | ||||||
Payments on finance lease obligations | ||||||
266 | 427 | - | - | - | - | - |
Net cash used in investing activities | ||||||
- | - | - | -1,833 | -251 | -102 | -7 |
Payments on capital lease obligations | ||||||
- | - | 408 | 80 | - | - | - |
Net cash provided by financing activities | ||||||
- | - | - | 30,648 | - | - | 16,419 |
Net (decrease) increase in cash, cash equivalents and restricted cash | ||||||
- | - | - | 8,407 | - | - | - |
Proceeds from exercise of stock options | ||||||
- | 244 | 5 | - | 67 | 209 | 1 |
Proceeds from sale of common stock, net of issuance costs | ||||||
56,996 | 82,666 | - | - | 60,280 | 0 | - |
Proceeds from sale of pre-funded warrants, net of issuance costs | ||||||
22,874 | - | - | - | - | - | - |
Proceeds from sale of convertible preferred stock, net of issuance costs | ||||||
- | - | 40,433 | - | 41,433 | 0 | 16,418 |
Proceeds from sale of preferred units, net of issuance costs | ||||||
- | - | 26,648 | 30,728 | - | - | - |
Net cash used in financing activities | ||||||
79,604 | 82,483 | 66,678 | - | 101,780 | 209 | - |
Net increase (decrease) in cash, cash equivalents and restricted cash | ||||||
14,932 | -47,188 | 44,901 | - | - | - | - |
Landlord funded allowance for tenant improvements | ||||||
- | 1,654 | 4,961 | 1,295 | - | - | - |
Property and equipment purchases included in accounts payable and accrued expenses | ||||||
-369 | 169 | - | - | - | - | - |
Assets acquired under operating lease obligation | ||||||
2,714 | - | - | - | - | - | - |
Property and equipment purchases included in accounts payable and accrued expenses | ||||||
- | - | 147 | 41 | - | - | - |
Cash paid for interest | ||||||
21 | 43 | 35 | - | - | - | - |
Cash paid for interest | ||||||
- | - | - | 8 | - | - | - |
Purchase under capital lease | ||||||
- | 12 | 918 | 367 | - | - | - |
Prior period adjustment related to the adoption of ASU 2016-09 | ||||||
- | - | 29 | - | - | - | - |
Net increase (decrease) in cash and cash equivalents | ||||||
- | - | - | - | 80,394 | -13,863 | 9,916 |
Conversion of preferred stock to common stock | ||||||
- | - | - | - | 100,938 | 0 | - |