| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Revenue | ||||||||||||||||||||
2,379 | 508 | 558 | 462 | 454 | 893 | 412 | 375 | 370 | 0 | 0 | 0 | 1,101 | - | - | - | - | - | - | - | - |
Revenue | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | 317 | - | - | - | - | - | 317 | - |
Operating expenses: | ||||||||||||||||||||
Research and development | ||||||||||||||||||||
14,569 | 14,277 | 15,931 | 15,475 | 12,562 | 15,128 | 12,856 | 11,082 | 11,116 | 11,780 | 10,447 | 10,041 | 9,628 | 8,443 | 11,584 | 9,525 | 8,265 | 8,378 | 6,866 | 5,428 | 3,736 |
General and administrative | ||||||||||||||||||||
5,149 | 6,402 | 5,016 | 5,195 | 4,865 | 4,372 | 3,876 | 3,841 | 4,075 | 3,740 | 3,593 | 3,472 | 3,086 | 2,919 | 2,633 | 2,540 | 2,371 | 2,311 | 1,598 | 984 | 836 |
Total operating expenses | ||||||||||||||||||||
19,718 | 20,679 | 20,947 | 20,670 | 17,427 | 19,500 | 16,732 | 14,923 | 15,191 | 15,520 | 14,040 | 13,513 | 12,714 | 11,362 | 14,217 | 12,065 | 10,636 | 10,689 | 8,464 | 6,412 | 4,572 |
Loss from operations | ||||||||||||||||||||
-17,339 | -20,171 | -20,389 | -20,208 | -16,973 | -18,607 | -16,320 | -14,548 | -14,821 | -15,520 | -14,040 | -13,513 | -11,613 | -11,045 | -14,217 | -12,065 | -10,636 | -10,689 | -8,464 | -6,095 | -4,572 |
Other income, net | ||||||||||||||||||||
113 | 442 | 596 | 753 | 512 | 575 | 583 | 501 | 358 | 218 | 215 | 145 | 98 | 80 | 48 | 44 | 48 | 0 | 0 | -2 | 4 |
Net loss | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | -10,965 | -14,169 | -12,021 | -10,588 | -10,689 | -8,464 | -6,097 | -4,568 |
Accrued dividends on preferred stock | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 121 | 1,823 | 1,737 | 1,244 | 1,243 | 1,230 | 1,217 |
Net loss applicable to common stockholders | ||||||||||||||||||||
-17,226 | -19,729 | -19,793 | -19,455 | -16,461 | -18,032 | -15,737 | -14,047 | -14,463 | -15,302 | -13,825 | -13,368 | -11,515 | -10,965 | -14,290 | -13,844 | -12,325 | -11,933 | -9,707 | -7,327 | -5,785 |
Net loss per share applicable to common stockholders - basic and diluted | ||||||||||||||||||||
-0.39 | -0.46 | -0.47 | -0.47 | -0.49 | -0.54 | -0.47 | -0.43 | -0.48 | -0.58 | -0.53 | -0.52 | -0.49 | -0.47 | -0.65 | -5.42 | -5.15 | -5.14 | -4.51 | -4.16 | -3.44 |
Weighted-average number of common shares used in net loss per share applicable to common stockholders - basic and diluted | ||||||||||||||||||||
43,923 | 42,885 | 42,439 | 41,673 | 33,766 | 33,694 | 33,653 | 32,892 | 30,335 | 26,316 | 26,259 | 25,584 | 23,393 | 23,374 | 22,012 | 2,553 | 2,394 | 2,320 | 2,150 | 1,761 | 1,682 |