| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Revenue | ||||||||||||||||||||
3,907 | 1,982 | 2,367 | 2,221 | 2,134 | 2,050 | 1,157 | 745 | 370 | 1,101 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Revenue | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | 0 | - | - | - | - | - | 0 | - |
Operating expenses: | ||||||||||||||||||||
Research and development | ||||||||||||||||||||
60,252 | 58,245 | 59,096 | 56,021 | 51,628 | 50,182 | 46,834 | 44,425 | 43,384 | 41,896 | 38,559 | 39,696 | 39,180 | 37,817 | 37,752 | 33,034 | 28,937 | 24,408 | 0 | 0 | 0 |
General and administrative | ||||||||||||||||||||
21,762 | 21,478 | 19,448 | 18,308 | 16,954 | 16,164 | 15,532 | 15,249 | 14,880 | 13,891 | 13,070 | 12,110 | 11,178 | 10,463 | 9,855 | 8,820 | 7,264 | 5,729 | 0 | 0 | 0 |
Total operating expenses | ||||||||||||||||||||
82,014 | 79,723 | 78,544 | 74,329 | 68,582 | 66,346 | 62,366 | 59,674 | 58,264 | 55,787 | 51,629 | 51,806 | 50,358 | 48,280 | 47,607 | 41,854 | 36,201 | 30,137 | 0 | 0 | 0 |
Loss from operations | ||||||||||||||||||||
-78,107 | -77,741 | -76,177 | -72,108 | -66,448 | -64,296 | -61,209 | -58,929 | -57,894 | -54,686 | -50,211 | -50,388 | -48,940 | -47,963 | -47,607 | -41,854 | -35,884 | -29,820 | 0 | 0 | 0 |
Other income, net | ||||||||||||||||||||
1,904 | 2,303 | 2,436 | 2,423 | 2,171 | 2,017 | 1,660 | 1,292 | 936 | 676 | 538 | 371 | 270 | 220 | 140 | 92 | 46 | 2 | 0 | 0 | 0 |
Net loss | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | -47,743 | -47,467 | -41,762 | -35,838 | -29,818 | 0 | 0 | 0 |
Accrued dividends on preferred stock | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | 3,681 | 4,925 | 6,047 | 5,454 | 4,934 | 0 | 0 | 0 |
Net loss applicable to common stockholders | ||||||||||||||||||||
-76,203 | -75,438 | -73,741 | -69,685 | -64,277 | -62,279 | -59,549 | -57,637 | -56,958 | -54,010 | -49,673 | -50,138 | -50,614 | -51,424 | -52,392 | -47,809 | -41,292 | -34,752 | 0 | 0 | 0 |
Net loss per share applicable to common stockholders - basic and diluted | ||||||||||||||||||||
-0.39 | -0.46 | -0.47 | -0.47 | -0.49 | -0.54 | -0.47 | -0.43 | -0.48 | -0.58 | -0.53 | -0.52 | -0.49 | -0.47 | -0.65 | -5.42 | -5.15 | -5.14 | -4.51 | -4.16 | -3.44 |
Weighted-average number of common shares used in net loss per share applicable to common stockholders - basic and diluted | ||||||||||||||||||||
43,923 | 42,885 | 42,439 | 41,673 | 33,766 | 33,694 | 33,653 | 32,892 | 30,335 | 26,316 | 26,259 | 25,584 | 23,393 | 23,374 | 22,012 | 2,553 | 2,394 | 2,320 | 2,150 | 1,761 | 1,682 |