| Dec'19 | Dec'18 | Dec'17 | Dec'16 | |||
|---|---|---|---|---|---|---|
Operating expenses: | ||||||
Research and development | ||||||
133,028 | 85,594 | 35,906 | 21,820 | |||
General and administrative | ||||||
45,796 | 18,001 | 11,216 | 5,363 | |||
Total operating expenses | ||||||
178,824 | 103,595 | 47,122 | 27,183 | |||
Loss from operations | ||||||
-178,824 | -103,595 | -47,122 | -27,183 | |||
Change in fair value—preferred stock tranche obligation | ||||||
0 | 0 | 5,649 | -1,571 | |||
Other income (expense), net | ||||||
7,663 | 3,924 | 183 | 103 | |||
Interest expense | ||||||
5,744 | 3,137 | 0 | 0 | |||
Loss before income taxes | ||||||
-176,905 | -102,808 | -41,290 | - | |||
Income tax benefit | ||||||
-100 | 0 | 0 | - | |||
Net loss | ||||||
-176,813 | -102,808 | -41,290 | -28,651 | |||
Other comprehensive income (loss): | ||||||
Net unrealized gain (loss) on available-for-sale investments, net of tax | ||||||
346 | -140 | -13 | 0 | |||
Total comprehensive loss | ||||||
-176,467 | -102,948 | -41,303 | -28,651 | |||
Net loss per share, basic and diluted (in USD per share) | ||||||
-3.72 | -4.64 | -19.32 | -15.69 | |||
Weighted-average number of shares outstanding, basic and diluted (in shares) | ||||||
47,521 | 22,146 | 2,137 | 1,826 | |||