| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 | Dec'14 | Sep'14 | Jun'14 | Mar'14 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Collaboration revenue | ||||||||||||||||||||||||
- | - | 0 | 0 | - | 3,000 | 10,498 | 11,129 | 0 | - | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - |
Collaboration revenue | ||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | 2,865 | - | 4,227 | 4,592 | 7,982 | 7,904 | 7,549 | 7,502 | 4,374 | 3,598 | 0 | 0 | 0 |
Operating expenses: | ||||||||||||||||||||||||
Research and development | ||||||||||||||||||||||||
11,314 | 14,530 | 18,548 | 22,468 | 26,236 | 30,460 | 29,152 | 26,433 | 23,211 | 19,355 | 19,499 | 19,773 | 21,653 | 21,566 | 27,358 | 28,712 | 27,344 | 25,680 | 17,683 | 14,067 | 10,222 | 7,652 | 0 | 0 | 0 |
General and administrative | ||||||||||||||||||||||||
7,703 | 7,766 | 7,667 | 7,749 | 7,478 | 7,280 | 7,211 | 6,951 | 7,397 | 7,610 | 7,804 | 7,838 | 7,814 | 7,859 | 7,606 | 7,255 | 6,687 | 5,691 | 4,750 | 3,787 | 2,711 | 2,125 | 0 | 0 | 0 |
Total operating expenses | ||||||||||||||||||||||||
19,017 | 22,296 | 26,215 | 30,217 | 33,714 | 37,740 | 36,363 | 33,384 | 30,608 | 26,965 | 27,303 | 27,611 | 29,467 | 29,425 | 34,964 | 35,967 | 34,031 | 31,371 | 22,433 | 17,854 | 12,933 | 9,777 | 0 | 0 | 0 |
Loss from operations | ||||||||||||||||||||||||
-19,017 | -22,296 | -26,215 | -30,217 | -33,714 | -34,740 | -33,363 | -22,886 | -19,479 | -18,210 | -17,931 | -24,922 | -26,602 | -25,976 | -30,737 | -31,375 | -26,049 | -23,467 | -14,884 | -10,352 | -8,559 | -6,179 | 0 | 0 | 0 |
Other expense: | ||||||||||||||||||||||||
Interest expense, net | ||||||||||||||||||||||||
-473 | -386 | -280 | -172 | -108 | -231 | -409 | -620 | -830 | -886 | -929 | -993 | -1,051 | -1,119 | -1,092 | -1,029 | 0 | - | 0 | 0 | - | - | - | - | - |
Interest expense, net | ||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | - | 0 | 0 | 0 |
Other expense, net | ||||||||||||||||||||||||
8 | 8 | 1 | 9 | 14 | 12 | 9 | -2 | -11 | -7 | 3 | 17 | 24 | 87 | 89 | 85 | 68 | -20 | -42 | -43 | -25 | 37 | 0 | 0 | 0 |
Total other expense | ||||||||||||||||||||||||
-465 | -378 | -279 | -163 | -94 | -219 | -400 | -622 | -841 | -893 | -926 | -976 | -1,027 | -1,032 | -1,004 | -942 | -892 | -943 | -1,028 | -1,032 | -884 | -630 | 0 | 0 | 0 |
Net loss | ||||||||||||||||||||||||
-19,482 | -22,674 | -26,494 | -30,380 | -33,808 | -34,959 | -33,763 | -23,508 | -20,320 | -19,103 | -18,857 | -25,898 | -27,629 | -27,008 | -31,741 | -32,317 | -26,941 | -24,410 | -15,912 | -11,384 | -9,443 | -6,809 | 0 | 0 | 0 |
Accretion to redemption value of redeemable convertible preferred stock | ||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 31 | 0 | 0 | 0 | - | - | - | - |
Accretion to redemption value of redeemable convertible preferred stock | ||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 0 | 0 |
Net loss attributable to common stockholders | ||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -24,441 | -16,038 | -11,580 | -9,705 | -7,106 | 0 | 0 | 0 |
Net loss per share, basic and diluted | ||||||||||||||||||||||||
-0.78 | -4.68 | -0.17 | -0.21 | -2.41 | -11.88 | -0.30 | -0.33 | -0.46 | -10.60 | 0.07 | -0.40 | -0.44 | -0.43 | -0.48 | -0.68 | -0.54 | -0.93 | -0.53 | -0.24 | -0.50 | -1.64 | -1.23 | -0.65 | -0.88 |
Weighted-average shares outstanding, basic | ||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | 16,828 | - | - | - | 12,227 | - | - | - | - | - | - | - | - | - | - |
Weighted-average shares outstanding, diluted | ||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | 17,137 | - | - | - | 12,227 | - | - | - | - | - | - | - | - | - | - |
Weighted-average shares outstanding, basic and diluted | ||||||||||||||||||||||||
5,171 | -50,718 | 29,937 | 29,929 | 2,989 | -66,980 | 29,837 | 29,706 | 18,214 | - | - | 16,610 | 16,206 | - | - | 12,195 | 12,179 | 12,223 | 12,117 | 12,096 | 8,024 | 1,615 | 1,615 | 1,614 | 1,614 |