| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Mar'12 | Dec'11 |
|---|---|---|---|---|---|---|---|---|---|
CASH FLOWS FROM OPERATING ACTIVITIES | |||||||||
Consolidated net loss | |||||||||
-172,871 | -173,482 | -118,476 | -78,253 | -62,948 | -55,781 | -20,478 | -26,182 | -18,285 | -889 |
Adjustments to reconcile net loss to net cash used in operating activities: | |||||||||
Gain on settlement of notes payable | |||||||||
- | - | - | - | - | 95 | 0 | - | - | - |
Gain on sale of long-term securities | |||||||||
- | - | - | -33 | 0 | 0 | - | - | - | - |
Recognized stock based compensation expense | |||||||||
11,335 | 12,886 | 15,945 | 7,510 | - | - | - | - | - | - |
Non-cash stock compensation expense | |||||||||
- | - | - | - | 15,697 | 21,105 | 5,203 | 3,422 | 275 | 86 |
Shares issued in connection with in-licensing agreement | |||||||||
100 | 4,000 | 0 | 0 | - | 5,350 | 0 | 16,578 | 16,875 | -297 |
Impairment of in-process research and development | |||||||||
- | - | - | - | - | - | 2,797 | 1,104 | - | 0 |
Depreciation and amortization | |||||||||
100 | 88 | 82 | 63 | 15 | 3 | 1 | 0 | - | 0 |
Amortization of premium on investment securities | |||||||||
257 | 119 | 61 | 459 | 536 | 193 | 0 | 0 | - | - |
Amortization of debt issuance costs | |||||||||
800 | 0 | 0 | - | - | - | - | - | - | - |
Amortization of leasehold interest | |||||||||
182 | 135 | 125 | - | - | - | - | - | - | - |
Non-cash change in lease liability and right-of-use asset | |||||||||
2,519 | 0 | 0 | - | - | - | - | - | - | - |
Change in fair value of notes payable | |||||||||
-124 | 61 | -59 | 110 | 56 | -210 | 2,414 | 815 | - | 0 |
Changes in assets and liabilities: | |||||||||
Increase in restricted cash | |||||||||
- | - | - | - | 4 | 575 | 0 | - | - | - |
Increase in other current assets | |||||||||
-1,395 | 1,638 | 2,665 | -3,565 | 3,105 | 4,563 | -229 | 1,932 | - | -3 |
Decrease (increase) in leasehold interest | |||||||||
- | - | - | -2,042 | 0 | 0 | - | - | - | - |
Increase in accrued interest receivable | |||||||||
11 | -14 | 25 | -102 | 100 | 58 | 27 | 0 | - | - |
Decrease in other assets | |||||||||
0 | 0 | -162 | 5 | 41 | 0 | 0 | 0 | - | - |
Decrease in other current assets | |||||||||
- | - | - | - | - | - | - | - | -11 | - |
(Decrease) increase in accounts payable and accrued expenses | |||||||||
-4,795 | 10,957 | 11,020 | 6,493 | 5,470 | -603 | 4,034 | 595 | 153 | 408 |
Decrease in lease liabilities | |||||||||
-1,548 | 0 | 0 | 0 | - | - | - | - | - | - |
(Decrease) increase in interest payable | |||||||||
1,491 | 0 | 0 | - | - | -94 | 66 | 61 | 21 | 7 |
Decrease in other liabilities | |||||||||
28,810 | 18,350 | 0 | - | - | - | - | - | - | - |
Increase in deferred rent | |||||||||
0 | -97 | -104 | 816 | 0 | 0 | - | - | - | - |
Decrease in deferred revenue | |||||||||
-152 | -152 | -152 | -152 | -152 | -152 | -152 | 1,980 | - | 0 |
Net cash used in operating activities | |||||||||
-132,806 | -128,925 | -93,760 | - | - | - | - | - | -948 | -86 |
Net cash used in operating activities | |||||||||
- | - | - | -61,587 | -44,690 | -35,059 | -10,739 | -5,187 | - | - |
CASH FLOWS FROM INVESTING ACTIVITIES | |||||||||
Proceeds from maturity of short-term securities | |||||||||
29,250 | 32,500 | 19,800 | 29,500 | 24,350 | 0 | 0 | - | - | - |
Investment in held-to-maturity long-term securities | |||||||||
- | - | - | - | - | - | - | 0 | - | - |
Investment in held-to-maturity securities | |||||||||
29,837 | 31,230 | 28,006 | 15,200 | 48,993 | 18,336 | 4,919 | - | - | - |
Purchases of equipment | |||||||||
131 | 90 | 2 | 344 | 42 | 18 | 5 | 1 | - | 0 |
Proceeds from the sale of long-term securities | |||||||||
- | - | - | 12,589 | 0 | 0 | - | - | - | - |
Cash acquired in connection with acquisition | |||||||||
- | - | - | - | - | - | - | 0 | 10 | 10 |
Net cash provided by (used in) investing activities | |||||||||
-718 | 1,180 | -8,208 | - | - | - | - | - | 10 | 10 |
Net cash (used in) provided by investing activities | |||||||||
- | - | - | 26,545 | -24,685 | -18,355 | -4,925 | -1 | - | - |
CASH FLOWS FROM FINANCING ACTIVITIES | |||||||||
Proceeds from the exercise of options | |||||||||
- | - | - | - | - | 202 | 0 | - | - | - |
Payment of notes payable | |||||||||
- | - | - | - | - | 677 | 0 | - | - | - |
Proceeds from sale of common stock, net | |||||||||
175,021 | 113,639 | 131,516 | 4,411 | 67,760 | 65,614 | 37,648 | - | - | - |
Proceeds from exercise of options | |||||||||
0 | 0 | 2,143 | 618 | 1,067 | 3,556 | 2,280 | 0 | - | - |
Proceeds from debt financings | |||||||||
29,987 | 0 | 0 | - | - | - | - | - | - | - |
Financing costs paid | |||||||||
795 | 0 | 0 | 13 | 104 | 51 | 85 | - | - | - |
Payments of short-term loans | |||||||||
- | - | - | - | - | - | - | 200 | 200 | 0 |
Proceeds from sale of common stock, net | |||||||||
- | - | - | - | - | - | - | 0 | 9,824 | 9,824 |
Proceeds from sale of preferred stock, net | |||||||||
- | - | - | - | - | - | - | 12,257 | 12,257 | 0 |
Offering costs paid | |||||||||
- | - | - | - | - | - | - | 75 | 20 | 0 |
Purchase of treasury stock | |||||||||
- | - | - | - | - | - | 149 | 84 | - | 0 |
Net cash provided by financing activities | |||||||||
- | - | - | 5,016 | 68,723 | 68,643 | 39,694 | 11,896 | - | - |
Net cash provided by financing activities | |||||||||
204,213 | 113,639 | 133,659 | - | - | - | - | - | 21,861 | 9,824 |
NET (DECREASE) INCREASE IN CASH, CASH EQUIVALENTS AND RESTRICTED CASH | |||||||||
70,689 | -14,106 | 31,691 | -30,026 | -652 | 15,228 | 24,029 | 6,707 | 20,923 | 9,748 |
NONCASH TRANSACTIONS | |||||||||
Reclassification of deferred financing costs to additional paid-in capital | |||||||||
- | - | - | -25 | -111 | 0 | 0 | - | - | - |
Conversion of convertible notes payable to common stock | |||||||||
- | - | - | 33 | 6 | 0 | 0 | - | - | - |
Conversion of notes payable to preferred stock | |||||||||
- | - | - | - | - | - | - | 0 | 55 | 55 |
Deferred financing costs | |||||||||
- | - | - | - | - | - | - | 0 | 116 | 61 |