| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | ||
|---|---|---|---|---|---|---|
OPERATING ACTIVITIES | ||||||
Net loss | ||||||
-63,516 | -48,955 | -38,929 | -33,478 | -23,056 | ||
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||
Stock-based compensation | ||||||
8,060 | 6,870 | 4,451 | 1,323 | 1,062 | ||
Depreciation | ||||||
843 | 625 | 292 | 255 | 232 | ||
Amortization of premium (discount) on investments, net | ||||||
- | - | - | - | -5 | ||
Loss on disposal of property and equipment | ||||||
-1,212 | - | - | 20 | 15 | ||
Noncash interest expense | ||||||
1,698 | 1,161 | 590 | 570 | - | ||
Noncash interest expense | ||||||
- | - | - | - | 94 | ||
Change in fair value of preferred stock warrants | ||||||
- | - | -37 | -50 | -111 | ||
Accretion of discount on investments, net | ||||||
-161 | 248 | 19 | 9 | - | ||
Gain on lease modification | ||||||
1,439 | - | - | - | - | ||
Changes in operating assets and liabilities: | ||||||
Prepaid expenses and other assets | ||||||
-2,502 | 208 | 679 | 157 | 1,072 | ||
Accounts payable | ||||||
-58 | 1,260 | 304 | 586 | 571 | ||
Accrued liabilities | ||||||
-8,911 | 4,127 | 2,946 | 1,547 | 1,301 | ||
Deferred license revenue | ||||||
-36 | -36 | -41 | -49 | - | ||
Other | ||||||
246 | 935 | -11 | - | - | ||
Deferred license revenue | ||||||
- | - | - | - | -51 | ||
Deferred grant funding | ||||||
- | - | - | -57 | -2 | ||
Net cash used in operating activities | ||||||
-59,238 | -34,469 | -31,133 | -29,539 | - | ||
INVESTING ACTIVITIES | ||||||
Net cash used in operating activities | ||||||
- | - | - | - | -21,042 | ||
Proceeds from the sale/maturity of marketable securities | ||||||
93,473 | 68,524 | 43,725 | 48,095 | 35,158 | ||
Purchases of marketable securities | ||||||
51,163 | 70,746 | 70,797 | 23,003 | 59,870 | ||
Purchases of property and equipment | ||||||
428 | 1,968 | 655 | 525 | 231 | ||
Proceeds from sale of property and equipment | ||||||
437 | - | 20 | - | 15 | ||
Net cash provided by investing activities | ||||||
42,319 | -4,190 | -27,707 | 24,567 | - | ||
FINANCING ACTIVITIES | ||||||
Proceeds from issuance of notes payable, net of issuance costs | ||||||
- | 26,325 | - | - | 17,666 | ||
Cash paid on extinguishment of debt | ||||||
- | 8,631 | - | - | - | ||
Proceeds from issuance of convertible preferred stock, net of issuance costs | ||||||
- | - | - | - | 33,075 | ||
Principal payments on notes payable | ||||||
23,155 | 3,000 | 7,200 | 600 | - | ||
Proceeds from issuance of common stock | ||||||
551 | 661 | 507 | 10 | 157 | ||
Net cash (used in) provided by investing activities | ||||||
- | - | - | - | -24,928 | ||
Proceeds from offering of common stock, net of issuance costs | ||||||
7,696 | 28,200 | 88,618 | - | - | ||
Proceeds from issuance of convertible promissory notes, net of issuance costs | ||||||
- | - | 7,338 | 3,374 | - | ||
Proceeds from convertible promissory note subscriptions | ||||||
- | - | - | 140 | - | ||
Cash paid for deferred equity issuance costs | ||||||
- | 16 | - | 592 | 982 | ||
Net cash (used in) provided by financing activities | ||||||
-14,908 | 43,539 | 89,263 | 2,332 | - | ||
Net increase (decrease) in cash and cash equivalents | ||||||
-31,827 | 4,880 | 30,423 | - | - | ||
Net cash (used in) provided by financing activities | ||||||
- | - | - | - | 49,916 | ||
Net decrease in cash and cash equivalents | ||||||
- | - | - | -2,640 | 3,946 | ||
Cash paid for interest | ||||||
- | - | - | 1,460 | 124 | ||
Allowance for tenant improvements included in deferred rent | ||||||
- | 1,243 | - | - | - | ||
NONCASH INVESTING AND FINANCING ACTIVITIES | ||||||
SUPPLEMENTAL DISCLOSURES OF CASH FLOW INFORMATION | ||||||
Cash paid for interest | ||||||
2,290 | 1,522 | 1,210 | - | - | ||
Property and equipment purchases included in accounts payable and accrued liabilities | ||||||
- | 178 | 111 | 28 | - | ||
Fair value of common stock warrants issued in connection with notes payable | ||||||
- | 479 | - | - | - | ||
Convertible preferred stock converted into shares of common stock | ||||||
- | - | 131,410 | - | - | ||
Convertible promissory notes principal and accrued interest converted into shares of common stock | ||||||
- | - | 11,057 | - | - | ||
Preferred stock warrant liabilities converted into warrants to purchase shares of common stock | ||||||
- | - | 89 | - | - | ||
Fair value of preferred stock warrants issued in connection with notes payable | ||||||
- | - | - | - | 287 | ||
Deferred equity issuance costs paid in previous periods reclassified to equity on effective date of initial public offering | ||||||
- | - | 1,574 | - | - | ||
Deferred equity issuance costs in accounts payable and accrued liabilities | ||||||
- | 310 | 96 | 226 | 543 | ||