| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | ||
|---|---|---|---|---|---|---|
License revenue | ||||||
36 | 18,036 | 41 | 49 | - | ||
License revenue | ||||||
- | - | - | - | 51 | ||
Operating expenses: | ||||||
Research and development | ||||||
45,299 | 51,080 | 29,113 | 27,218 | 19,172 | ||
General and administrative | ||||||
16,248 | 12,809 | 8,556 | 4,521 | 3,833 | ||
Total operating expenses | ||||||
61,547 | 63,889 | 37,669 | 31,739 | 23,005 | ||
Loss from operations | ||||||
-61,511 | -45,853 | -37,628 | -31,690 | -22,954 | ||
Other income (expense), net: | ||||||
Interest income | ||||||
1,564 | 1,534 | 595 | 215 | 126 | ||
Interest expense | ||||||
3,820 | 2,930 | 1,932 | 2,052 | 339 | ||
Loss on disposal of assets | ||||||
-1,187 | -7 | - | - | - | ||
Gain on lease modification | ||||||
1,439 | - | - | - | - | ||
Change in fair value of preferred stock warrants | ||||||
- | - | -37 | -50 | -111 | ||
Loss before income taxes | ||||||
-63,515 | -47,256 | -38,928 | -33,477 | - | ||
Income tax expense | ||||||
1 | 1,699 | 1 | 1 | - | ||
Total other expense, net | ||||||
- | - | - | - | -102 | ||
Net loss | ||||||
-63,516 | -48,955 | -38,929 | -33,478 | -23,056 | ||
Other comprehensive income (loss): | ||||||
Net unrealized (loss) gain on investments | ||||||
33 | 11 | -34 | 58 | -52 | ||
Comprehensive loss | ||||||
-63,483 | -48,944 | -38,963 | -33,420 | -23,108 | ||
Net loss per common share, basic and diluted | ||||||
-2.69 | -2.44 | -2.66 | -15.22 | -10.57 | ||
Weighted-average number of common shares outstanding, basic and diluted | ||||||
23,630 | 20,059 | 14,607 | 2,199 | 2,182 | ||