| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 |
|---|---|---|---|---|---|---|
Revenue: | ||||||
Total revenue | ||||||
31 | 5,732 | 0 | 3,750 | - | - | - |
Grant revenue | ||||||
- | - | - | - | - | - | 84 |
Alliance revenue | ||||||
- | - | - | - | 6,250 | - | 50 |
Total revenue | ||||||
- | - | - | - | 6,250 | - | 134 |
Operating expenses: | ||||||
General and administrative | ||||||
13,212 | 18,979 | 19,639 | 16,077 | 12,797 | 9,403 | 4,718 |
Research and development | ||||||
13,291 | 15,824 | 48,974 | 89,956 | 44,074 | 40,547 | 18,762 |
Restructuring charges | ||||||
- | 1,427 | 1,774 | - | 0 | - | - |
Impairment of property and equipment | ||||||
108 | - | - | - | - | - | - |
Total operating expenses | ||||||
26,611 | 36,230 | 70,387 | 106,033 | 56,871 | 49,950 | 23,480 |
Loss from operations | ||||||
-26,580 | -30,498 | -70,387 | -102,283 | -50,621 | -49,950 | -23,345 |
Other income (expense): | ||||||
Change in fair value of warrant liability | ||||||
4 | -9 | -65 | -78 | 70 | -122 | -241 |
Net (loss) gain on asset disposals | ||||||
-12 | 107 | -56 | 222 | -8 | -4 | - |
Other income, net | ||||||
2,254 | 1,567 | 614 | -16 | 174 | 185 | - |
Miscellaneous income | ||||||
- | - | - | - | - | - | 1 |
Interest income | ||||||
418 | 1,001 | 679 | 743 | 331 | 17 | 0 |
Interest expense | ||||||
931 | 2,231 | 2,780 | 1,738 | 334 | 71 | 149 |
Gain on foreign currency exchange | ||||||
-16 | 6 | - | - | - | - | - |
Total other income | ||||||
1,709 | 459 | -1,478 | -711 | 93 | 249 | 93 |
Loss before income tax expense | ||||||
-24,871 | -30,039 | -71,865 | -102,994 | - | - | - |
Foreign income tax expense | ||||||
- | 745 | - | - | - | - | - |
Net loss | ||||||
- | - | - | - | - | -49,701 | -23,251 |
Accretion of redeemable convertible preferred stock | ||||||
- | - | - | - | - | 29 | 333 |
Net loss attributable to common stockholders | ||||||
-24,871 | -30,784 | -71,865 | -102,994 | -50,528 | -49,730 | -23,585 |
Other comprehensive gain, net: | ||||||
Unrealized gain on marketable securities | ||||||
9 | 33 | -44 | 208 | -187 | - | - |
Unrealized gain (loss) on marketable securities | ||||||
- | - | - | - | - | -19 | - |
Other comprehensive gain, net | ||||||
9 | 33 | -44 | 208 | -187 | -19 | - |
Comprehensive loss | ||||||
-24,862 | -30,751 | -71,909 | -102,786 | -50,715 | -49,749 | - |
Comprehensive loss | ||||||
- | - | - | - | - | - | -23,585 |
Per share information: | ||||||
Net loss per share of common stock, basic and diluted (in dollars per share) | ||||||
-0.27 | -0.42 | -1.21 | -1.97 | -1.15 | -2.02 | -29.71 |
Weighted average common shares outstanding, basic and diluted (in shares) | ||||||
91,677 | 73,558 | 59,436 | 52,398 | 43,794 | 24,655 | 793 |