| Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 |
|---|---|---|---|---|---|---|
Operating activities | ||||||
Net loss | ||||||
-496,126 | -374,224 | -247,749 | - | - | - | - |
Net loss | ||||||
- | - | - | -171,012 | -92,362 | -61,763 | -16,398 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||
Acquired in-process research and development | ||||||
10,000 | 18,940 | 2,000 | - | - | - | - |
Acquired in-process research and development | ||||||
- | - | - | 24,900 | 1,940 | 8,000 | 500 |
Depreciation and amortization expense | ||||||
9,530 | 3,113 | 1,037 | - | - | - | - |
Depreciation and amortization expense | ||||||
- | - | - | 349 | - | - | - |
Depreciation expense | ||||||
- | - | - | - | 179 | 64 | 35 |
Increase in fair value of investor rights obligation | ||||||
- | - | - | - | - | - | 1,010 |
Stock-based compensation expense | ||||||
90,426 | 48,455 | 25,914 | 11,683 | 7,759 | 1,803 | 305 |
Non-cash interest expense | ||||||
11,734 | 10,450 | 9,360 | 2,249 | - | - | - |
Write-down of inventory to net realizable value | ||||||
16,730 | - | - | - | - | - | - |
Loss on disposal of property and equipment | ||||||
- | - | - | -80 | - | - | - |
Changes in operating assets and liabilities: | ||||||
Accounts receivable | ||||||
47,134 | 3,634 | 2,562 | - | - | - | - |
Inventories | ||||||
59,968 | 13,594 | 1,106 | - | - | - | - |
Other assets | ||||||
20,214 | 7,770 | 3,639 | -2,327 | 3,112 | -1,020 | 2,709 |
Accounts payable | ||||||
-1,036 | -2,835 | 1,924 | 4,220 | -1,301 | 2,565 | 496 |
Accrued expenses | ||||||
80,837 | 31,896 | 20,077 | 6,209 | 1,996 | 5,565 | 2,612 |
Deferred revenues | ||||||
134 | 309 | 92 | - | - | - | - |
Other liabilities | ||||||
4,966 | 1,223 | 121 | 1,510 | 13 | -11 | 8 |
Net cash used in operating activities | ||||||
-400,121 | -287,671 | -194,531 | - | - | - | - |
Investing activities | ||||||
Net cash used in operating activities | ||||||
- | - | - | -117,485 | -84,888 | -42,757 | -14,141 |
Acquisition of product candidates, technology licenses and milestone payments | ||||||
59,665 | 18,940 | 17,000 | 24,900 | 1,940 | 8,000 | 500 |
Purchase of property and equipment | ||||||
5,978 | 2,895 | 2,305 | 1,011 | 400 | 165 | 98 |
Change in restricted cash | ||||||
870 | 1,489 | 500 | - | - | -200 | 100 |
Net cash provided by (used in) investing activities | ||||||
-66,513 | -23,324 | -19,805 | - | - | - | - |
Financing activities | ||||||
Net cash used in investing activities | ||||||
- | - | - | -25,911 | -2,340 | -7,965 | -698 |
Proceeds from term loan, net of issuance costs | ||||||
293,596 | - | - | 194,698 | - | - | - |
Purchase of capped call options | ||||||
- | - | - | 20,829 | - | - | - |
Proceeds from sale of common stock, net of issuance costs | ||||||
-8 | 838,099 | 179,753 | 94,199 | - | - | - |
Proceeds from exercise of stock options and Employee Stock Purchase Plan | ||||||
29,719 | 28,785 | 7,868 | - | - | - | - |
Net cash provided by financing activities | ||||||
323,307 | 866,884 | 187,621 | - | - | - | - |
Proceeds from sale of common stock, net of issuance costs | ||||||
- | - | - | - | 91,312 | 77,960 | - |
Proceeds from exercise of stock options | ||||||
- | - | - | 1,663 | 634 | 33 | - |
Proceeds from issuance of common stock under Employee Stock Purchase Plan | ||||||
- | - | - | 249 | 147 | - | - |
Payment of minimum tax withholdings on share-based awards | ||||||
- | - | - | 33 | - | - | - |
Proceeds from sale of convertible preferred stock, net of issuance costs | ||||||
- | - | - | - | - | 58,349 | - |
Proceeds from sale of convertible preferred and common stock and related investor rights, net of issuance costs | ||||||
- | - | - | - | - | - | 52,131 |
Net cash provided by financing activities | ||||||
- | - | - | 269,947 | 92,093 | 136,342 | 52,131 |
Effect of exchange rate changes on cash and cash equivalents | ||||||
545 | -158 | - | - | - | - | - |
Decrease in cash, cash equivalents, and restricted cash | ||||||
-142,782 | 555,731 | -26,715 | - | - | - | - |
Increase in cash and cash equivalents | ||||||
- | - | - | 126,551 | 4,865 | 85,620 | 37,292 |
Non-cash investing and financing activities | ||||||
Stock option exercise proceeds receivable as of period end | ||||||
- | 93 | 691 | - | - | - | - |
Leasehold improvement assets funded by lessor | ||||||
585 | 2,230 | - | - | - | - | - |
Settlement of investor rights obligation | ||||||
- | - | - | - | - | - | 3,829 |
Purchase of property and equipment - cash not paid as of period end | ||||||
40 | 230 | 238 | - | - | - | - |
Supplemental disclosure of cash flow information | ||||||
Cash paid for interest | ||||||
6,038 | 6,038 | 6,071 | - | - | - | - |
Income taxes paid | ||||||
573 | 1,430 | 1 | - | - | - | - |
Conversion of convertible preferred stock to common stock | ||||||
- | - | - | - | - | 122,697 | - |