| Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 |
|---|---|---|---|---|---|---|
Product revenue | ||||||
Licenses, collaboration and other revenues | ||||||
Revenues | ||||||
Revenue | ||||||
223,326 | 58,018 | 4,038 | - | - | - | - |
Expenses: | ||||||
Cost of sales - product | ||||||
41,137 | 1,203 | 62 | - | - | - | - |
Cost of sales - intangible asset amortization | ||||||
6,158 | 1,855 | 268 | - | - | - | - |
Research and development | ||||||
308,742 | 235,144 | 155,390 | 118,425 | 75,725 | 47,200 | 11,768 |
Selling, general and administrative | ||||||
336,808 | 158,578 | 78,701 | 23,935 | 14,780 | 6,715 | 3,158 |
Acquired in-process research and development | ||||||
10,000 | 18,940 | 2,000 | - | - | - | - |
Acquired in-process research and development | ||||||
- | - | - | 24,900 | 1,940 | 8,000 | 500 |
Total expenses | ||||||
702,845 | 415,720 | 236,421 | 167,260 | 92,445 | 61,915 | 15,426 |
Loss from operations | ||||||
-479,519 | -357,702 | -232,383 | -167,260 | -92,445 | -61,915 | -15,426 |
Interest expense | ||||||
19,758 | 16,487 | 15,414 | 3,776 | - | - | - |
Interest income | ||||||
4,147 | 1,440 | 48 | 24 | 83 | 152 | 38 |
Other income | ||||||
328 | - | - | - | - | - | - |
Loss before income taxes | ||||||
-494,802 | -372,749 | -247,749 | - | - | - | - |
Provision for (benefit from) income taxes | ||||||
1,324 | 1,475 | - | - | - | - | - |
Other income (expense), net | ||||||
- | - | - | - | - | - | -1,010 |
Net loss | ||||||
-496,126 | -374,224 | -247,749 | -171,012 | -92,362 | -61,763 | -16,398 |
Net loss per share applicable to common stockholders - basic and diluted (in dollars per share) | ||||||
-9.17 | -7.85 | -6.29 | -4.79 | -2.93 | -4.51 | -31.90 |
Weighted-average number of common shares used in net loss per share applicable to common stockholders - basic and diluted (in shares) | ||||||
54,080 | 47,652 | 39,387 | 35,739 | 31,559 | 13,696 | 514 |
Comprehensive income (loss): | ||||||
Net loss | ||||||
-496,126 | -374,224 | -247,749 | -171,012 | -92,362 | -61,763 | -16,398 |
Other comprehensive income (loss): | ||||||
Unrealized gain on pension obligation | ||||||
-3,359 | -2,782 | - | - | - | - | - |
Foreign currency translation adjustments | ||||||
401 | -142 | - | - | - | - | - |
Other comprehensive income (loss) | ||||||
-2,958 | -2,924 | - | - | - | - | - |
Comprehensive income (loss) | ||||||
-499,084 | -377,148 | -247,749 | -171,012 | -92,362 | -61,763 | -16,398 |