| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 |
|---|---|---|---|---|---|---|
Operating activities | ||||||
Net loss | ||||||
-12,599 | -22,999 | -31,003 | -31,358 | -33,704 | -29,373 | -25,580 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||
Depreciation and amortization | ||||||
4,117 | 3,920 | 3,841 | 3,511 | 2,254 | 1,175 | 999 |
Bad debt expense | ||||||
- | - | - | 68 | 105 | 54 | 109 |
(Gain) loss on disposal of property and equipment | ||||||
23 | 0 | -12 | -12 | 0 | 0 | - |
Contract with Customer, Liability, Revenue Recognized | ||||||
- | - | - | 948 | - | - | - |
Genzyme co-promotion fee amortization | ||||||
- | - | - | - | 1,897 | 2,269 | 2,500 |
Stock-based compensation | ||||||
9,807 | 5,958 | 6,617 | 6,378 | 5,602 | 3,548 | 1,247 |
Other income | ||||||
0 | -93 | 0 | 0 | - | - | - |
Conversion of accrued interest to long-term debt | ||||||
- | - | - | 385 | 0 | 0 | - |
Amortization of debt issuance costs | ||||||
83 | 32 | 472 | 173 | 46 | 97 | 56 |
Interest on end-of-term debt obligation and prepayment penalty | ||||||
229 | 312 | 1,589 | 206 | 79 | - | - |
Interest on end-of-term debt obligation | ||||||
- | - | - | - | - | 81 | 42 |
Change in value of preferred stock liability | ||||||
- | - | - | - | - | - | -2,070 |
Change in value of preferred stock warrant liability | ||||||
- | - | - | - | - | - | 86 |
Changes in operating assets and liabilities: | ||||||
Accounts receivable | ||||||
6,161 | 452 | 3,960 | 5,321 | 558 | 1,961 | 683 |
Supplies | ||||||
3,404 | -1,922 | 1,849 | -292 | 71 | 1,129 | 1,517 |
Prepaid expenses and other current assets | ||||||
-154 | 517 | 7 | 415 | -304 | 38 | 722 |
Right-of-use assets - operating lease and operating lease liability | ||||||
171 | 0 | 0 | - | - | - | - |
Other assets | ||||||
351 | 760 | 192 | -25 | 42 | 46 | -24 |
Accounts payable | ||||||
-141 | -1,568 | 1,728 | -1,441 | -3,546 | 1,874 | 3,348 |
Accrued liabilities | ||||||
5,228 | 724 | -1,163 | 451 | 4,463 | 355 | 3,862 |
Net cash used in operating activities | ||||||
-3,232 | -13,521 | -23,915 | -27,982 | -26,965 | -27,632 | -19,159 |
Investing activities | ||||||
Cash paid for acquisition | ||||||
40,000 | 0 | 0 | - | - | - | - |
Purchases of property and equipment | ||||||
2,756 | 1,874 | 1,755 | 4,210 | 6,165 | 2,024 | 1,332 |
Proceeds from disposal of property and equipment | ||||||
23 | 0 | 440 | 0 | 0 | 6,916 | - |
Change in restricted cash | ||||||
- | - | - | - | 533 | 70 | -50 |
Net cash used in investing activities | ||||||
-42,733 | -1,874 | -1,315 | -4,210 | -6,698 | -9,010 | -1,282 |
Financing activities | ||||||
Payment of deferred stock offering costs | ||||||
- | - | - | - | 247 | 0 | - |
Proceeds from the issuance of long-term debt, net of debt issuance costs | ||||||
0 | 0 | 24,880 | 24,452 | 0 | 0 | 4,877 |
Proceeds from issuance of redeemable convertible preferred stock, net of issuance costs | ||||||
- | - | - | - | - | - | 12,945 |
Proceeds from issuance of common stock in a private placement, net of issuance costs | ||||||
- | - | - | - | 37,258 | 0 | - |
Proceeds from issuance of common stock in a public offering, net of issuance costs | ||||||
137,848 | 55,038 | 200 | 31,949 | 0 | - | 66,304 |
Commissions and issuance costs relating to initial public offering | ||||||
- | - | - | - | - | 129 | 7,019 |
Payment of long-term debt | ||||||
24,900 | 0 | 25,385 | 5,000 | 0 | 0 | - |
Payment of end-of-term debt obligation and prepayment penalty | ||||||
0 | 0 | 1,536 | 288 | 0 | 110 | - |
Proceeds from legal settlement regarding short-swing profits | ||||||
0 | 403 | 0 | 0 | - | - | - |
Payment of financial lease liability | ||||||
308 | 292 | 274 | 0 | 0 | - | - |
Proceeds from the exercise of common stock options and employee stock purchases | ||||||
14,647 | 4,350 | 1,897 | 1,216 | 722 | 675 | 552 |
Net cash used in financing activities | ||||||
127,287 | 59,499 | -218 | 52,329 | 37,733 | 436 | 77,659 |
Supplementary cash flow information of non-cash investing and financing activities: | ||||||
Operating lease liability arising from obtaining right-of-use assets - operating lease at beginning of period | ||||||
14,118 | 0 | 0 | - | - | - | - |
Shares issued for purchase consideration for a business combination | ||||||
10,000 | 0 | 0 | - | - | - | - |
Deferred purchase consideration for a business combination | ||||||
6,088 | 0 | 0 | - | - | - | - |
Fair value of common stock issued for acquisition | ||||||
- | - | - | - | - | 10,078 | - |
Non-cash issuance of long-term debt | ||||||
- | - | - | - | - | 5,000 | - |
Non-cash repayment of long-term debt | ||||||
- | - | - | - | - | 5,000 | - |
Net receivable for reimbursement of public offering issuance costs | ||||||
- | - | - | 144 | 0 | 0 | - |
Purchases of property and equipment included in accounts payable and accrued liabilities | ||||||
226 | 273 | 42 | 363 | 1,825 | 383 | 25 |
Non-cash purchases of property and equipment | ||||||
- | - | - | - | - | - | 257 |
Transfer of preferred stock liability to equity | ||||||
- | - | - | - | - | - | 2,653 |
Preferred stock warrants | ||||||
- | - | - | - | - | - | 175 |
Conversion of preferred stock warrant liability to common stock warrants | ||||||
- | - | - | - | - | - | 261 |
Issuance of common stock from the non-cash exercise of common stock warrants | ||||||
- | - | - | - | - | 187 | - |
Supplementary cash flow information: | ||||||
Interest paid on debt | ||||||
332 | 1,547 | 2,718 | 2,149 | 278 | 307 | 132 |
Transfer of equity-based compensation from liabilities to equity | ||||||
- | - | - | - | - | - | 259 |
Cash paid for tax | ||||||
35 | 79 | 21 | 7 | 22 | 0 | - |
Conversion of convertible preferred stock to common stock | ||||||
- | - | - | - | - | - | 79,022 |
IPO costs included in accounts payable and accrued liabilities | ||||||
- | - | - | - | - | - | 129 |
Net decrease in cash, cash equivalents and restricted cash | ||||||
81,322 | 44,104 | -25,448 | 20,137 | 4,070 | -36,206 | 57,218 |