| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Revenue from Contract with Customer, Excluding Assessed Tax | ||||||||||
7,917 | 10,888 | 13,401 | 12,804 | - | - | - | - | - | - | - |
Contract revenue | ||||||||||
- | - | - | - | 18,860 | 13,304 | 5,846 | - | - | - | - |
Contract and grant revenue | ||||||||||
- | - | - | - | - | - | - | 6,176 | 4,223 | 6,249 | 3,692 |
License and royalty revenue | ||||||||||
- | - | 418 | 1,727 | 2,090 | 1,913 | 1,872 | 11,343 | 25,795 | 2,462 | 8,994 |
Total revenues | ||||||||||
- | - | 13,819 | 14,531 | 20,950 | 15,217 | 7,718 | 17,519 | 30,018 | 8,711 | 12,686 |
Operating expenses: | ||||||||||
Research and development | ||||||||||
20,214 | 12,960 | 14,391 | 10,355 | 11,061 | 11,467 | 14,558 | 17,340 | 17,975 | 19,692 | 23,449 |
Manufacturing and production | ||||||||||
- | - | 6,479 | 6,291 | 10,927 | 10,824 | 12,698 | 13,055 | 10,267 | 11,436 | 10,354 |
General and administrative | ||||||||||
12,171 | 6,379 | 6,335 | 7,062 | 8,366 | 9,552 | 11,814 | 10,557 | 9,598 | 8,798 | 7,469 |
Total operating expenses | ||||||||||
- | - | 27,205 | 23,708 | 30,354 | 31,843 | - | - | - | - | - |
Total operating expenses | ||||||||||
32,385 | 19,339 | - | - | - | - | 39,070 | 40,952 | 37,840 | 39,926 | 41,272 |
Loss from operations | ||||||||||
-24,468 | -8,451 | -13,386 | -9,177 | -9,404 | -16,626 | -31,352 | -23,433 | -7,822 | -31,215 | -28,586 |
Investment and other income (loss), net | ||||||||||
157 | 61 | - | - | - | - | - | - | - | - | - |
Gain (Loss) on Extinguishment of Debt | ||||||||||
2,318 | 0 | - | - | - | - | - | - | - | - | - |
Investment and other income, net | ||||||||||
- | - | 426 | 204 | 166 | 134 | 114 | 534 | - | - | - |
Investment and other income (expense), net | ||||||||||
- | - | - | - | - | - | - | - | 539 | - | - |
Investment and other income, net | ||||||||||
- | - | - | - | - | - | - | - | - | -830 | -30 |
Interest expense | ||||||||||
2,096 | 1,090 | - | - | - | - | - | - | - | - | 2 |
Liabilities, Fair Value Adjustment | ||||||||||
-11 | 0 | - | - | - | - | - | - | - | - | - |
Change in fair value of warrant liability | ||||||||||
-223 | -244 | - | - | - | - | - | - | - | - | - |
Net Income (Loss) Attributable to Parent | ||||||||||
-23,900 | -9,236 | -12,960 | -8,973 | -9,238 | -16,492 | -31,238 | -22,899 | -7,283 | -30,385 | -28,558 |
Reduction of redeemable convertible preferred stock to redemption value | ||||||||||
-10,274 | 5,936 | - | - | - | - | - | - | - | - | - |
Net income (loss) attributable to common stockholders | ||||||||||
-13,603 | -15,172 | - | - | - | - | - | - | - | - | - |
Net loss per common share share attributable to common stockholders, basic (in usd per share) | ||||||||||
-4.50 | -25.85 | -1.01 | -0.90 | -1.01 | -1.86 | -0.36 | -0.27 | -0.10 | -0.51 | -0.61 |
Weighted-average shares used to compute net loss per share attributable to common stockholders, basic (in shares) | ||||||||||
3,023 | 586 | 12,888 | 10,019 | 9,175 | 8,879 | 86,840 | 85,966 | 72,031 | 60,084 | 47 |