| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 |
|---|---|---|---|---|---|---|
Cash flows from operating activities | ||||||
Net loss | ||||||
-18,218 | -76,333 | - | - | - | - | - |
Net loss | ||||||
- | - | -84,979 | -95,817 | -82,177 | -57,513 | -18,497 |
Adjustments to reconcile net loss to net cash used in operating activities | ||||||
Depreciation and amortization | ||||||
498 | 1,060 | 311 | 215 | 194 | 107 | 17 |
Write-off of acquired in-process research & development | ||||||
- | 38,313 | - | - | - | - | - |
Loss on disposition of assets | ||||||
- | - | - | - | - | -26 | - |
Stock-based compensation expense | ||||||
3,399 | 16,139 | 13,349 | 10,923 | 10,699 | 4,641 | 215 |
Amortization of debt discount | ||||||
- | - | - | - | - | - | 121 |
Non-cash interest expense | ||||||
- | - | - | - | - | - | -7 |
Remeasurement of convertible preferred stock call option liability | ||||||
- | - | - | - | - | -9,560 | 969 |
Remeasurement of convertible preferred stock warrant liability | ||||||
- | - | - | - | - | 2,279 | 41 |
Changes in assets and liabilities | ||||||
Prepaid expenses and other assets | ||||||
2,782 | 224 | -3,940 | 1,626 | -317 | 1,695 | -383 |
Accounts payable | ||||||
652 | -1,744 | 142 | -315 | 413 | 944 | -675 |
Deferred revenue | ||||||
-146 | -1,371 | - | - | - | - | - |
Accrued liabilities | ||||||
- | - | -8,805 | - | - | - | - |
Accrued and other liabilities | ||||||
-484 | -5,097 | - | 5,742 | 1,490 | 1,998 | 2,267 |
Income taxes payable | ||||||
- | - | -247 | 247 | - | - | - |
Upfront payment from collaboration partner | ||||||
- | - | -40,000 | - | - | - | - |
Net cash used in operating activities | ||||||
-17,081 | -29,257 | -116,289 | - | - | - | - |
Cash flows from investing activities | ||||||
Purchase of property and equipment | ||||||
- | 33 | 745 | 90 | - | 827 | 9 |
Leasehold improvements for build-to-suit asset | ||||||
- | - | 3,558 | - | - | - | - |
Cash paid to acquire in-process research & development | ||||||
- | 2,076 | - | - | - | - | - |
Cash acquired in the merger transaction | ||||||
- | 5,277 | - | - | - | - | - |
Security deposit for facility lease | ||||||
- | - | - | - | -42 | 55 | - |
Net cash used in investing activities | ||||||
- | - | - | -90 | -42 | -772 | -9 |
Net cash provided by investing activities | ||||||
- | 3,168 | -4,303 | - | - | - | - |
Cash flows from financing activities | ||||||
Upfront payment from collaboration partner | ||||||
- | - | - | 40,000 | - | - | - |
Net cash used in operating activities | ||||||
- | - | - | -40,631 | -69,064 | -39,653 | -17,090 |
Inducement on build-to-suit lease obligation | ||||||
- | 1,896 | - | - | - | - | - |
Proceeds from issuance of common stock in initial public offering, net of issuance costs | ||||||
- | - | - | - | - | 132,137 | - |
Proceeds from issuance of common stock, net of issuance costs | ||||||
25,127 | - | 2,968 | 59,136 | 80,209 | - | - |
Proceeds from issuance of convertible preferred stock, net of issuance costs | ||||||
- | - | - | - | - | 64,793 | 29,956 |
Proceeds from exercise of convertible preferred stock warrants | ||||||
- | - | - | - | - | 572 | - |
Proceeds from issuance of common stock in connection with employee benefit plans | ||||||
123 | 52 | - | 669 | 400 | 201 | 27 |
Net cash provided by financing activities | ||||||
25,250 | 1,948 | 2,968 | - | - | - | - |
Net cash provided by financing activities | ||||||
- | - | - | 59,805 | 80,609 | 197,703 | 29,983 |
Net change in cash, cash equivalents, and restricted cash | ||||||
8,169 | -24,141 | -117,624 | - | - | - | - |
Net (decrease) increase in cash and cash equivalents | ||||||
- | - | - | 19,084 | 11,503 | 157,278 | 12,884 |
Supplemental disclosure of noncash items | ||||||
Build-to-suit lease transaction | ||||||
- | - | 5,428 | - | - | - | - |
Issuance of common stock for the merger transaction | ||||||
- | 37,331 | - | - | - | - | - |
Property and equipment recorded upon adoption of ASU 2016-02 | ||||||
2,151 | - | - | - | - | - | - |
Conversion of notes payable and accrued interest to preferred stock | ||||||
- | - | - | - | - | - | 4,588 |
Issuance of call options related to convertible preferred stock | ||||||
- | - | - | - | - | - | 1,116 |