| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Collaboration revenue | ||||||||||||||||||||
18,067 | 32,674 | 20,433 | 46,087 | 5,197 | 2,008 | 2,094 | 2,575 | 942 | 6,346 | 1,148 | 1,177 | 1,464 | 2,362 | 3,308 | 3,720 | 4,830 | 4,937 | 4,937 | 4,884 | 2,576 |
Operating expenses: | ||||||||||||||||||||
Research and development | ||||||||||||||||||||
32,294 | 36,551 | 29,777 | 28,576 | 24,831 | 16,913 | 16,632 | 16,507 | 14,853 | 13,327 | 19,561 | 15,300 | 14,072 | 12,724 | 10,309 | 10,484 | 8,732 | 9,220 | 6,481 | 6,455 | 5,523 |
General and administrative | ||||||||||||||||||||
10,206 | 9,891 | 8,463 | 8,322 | 9,659 | 8,256 | 6,609 | 11,762 | 7,182 | 5,366 | 4,942 | 4,516 | 4,914 | 3,481 | 3,370 | 2,854 | 3,565 | 3,157 | 2,475 | 2,396 | 1,881 |
Total operating expenses | ||||||||||||||||||||
42,500 | 46,442 | 38,240 | 36,898 | 34,490 | 25,169 | 23,241 | 28,269 | 22,035 | 18,693 | 24,503 | 19,816 | 18,986 | 16,205 | 13,679 | 13,338 | 12,297 | 12,377 | 8,956 | 8,851 | 7,404 |
Operating loss | ||||||||||||||||||||
-24,433 | -13,768 | -17,807 | 9,189 | -29,293 | -23,161 | -21,147 | -25,694 | -21,093 | -12,347 | -23,355 | -18,639 | -17,522 | -13,843 | -10,371 | -9,618 | -7,467 | -7,440 | -4,019 | -3,967 | -4,828 |
Other income: | ||||||||||||||||||||
Interest income | ||||||||||||||||||||
978 | 1,392 | 1,823 | 2,097 | 1,145 | 910 | 942 | 870 | 588 | 428 | 291 | 255 | 253 | -1,093 | 1,171 | 433 | 465 | - | 102 | 73 | - |
Other (expense) income | ||||||||||||||||||||
-808 | -198 | 978 | -133 | 978 | -281 | -84 | -717 | 399 | 122 | -282 | -297 | 395 | 617 | -99 | -150 | -186 | - | - | - | - |
Total other income | ||||||||||||||||||||
170 | 1,194 | 2,801 | 1,964 | 2,123 | 629 | 858 | 153 | 987 | 550 | 9 | -42 | 648 | -476 | 1,072 | 283 | 279 | - | 102 | - | - |
Loss before income taxes | ||||||||||||||||||||
- | - | -15,006 | 11,153 | - | -22,532 | -20,289 | -25,541 | -20,106 | -11,797 | -23,346 | -18,681 | -16,874 | -14,319 | -9,299 | -9,335 | -7,188 | - | -3,917 | - | - |
Income tax benefit | ||||||||||||||||||||
- | - | - | - | - | 0 | 0 | 0 | -180 | - | 0 | 195 | -226 | - | -303 | - | - | - | - | - | - |
Other financing expense | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1 | 9,749 |
Total other expense, net | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -72 | 9,749 |
Net loss | ||||||||||||||||||||
-24,263 | -12,574 | -15,006 | 11,153 | -27,170 | -22,532 | -20,289 | -25,541 | -19,926 | -11,828 | -23,346 | -18,876 | -16,648 | -14,674 | -8,996 | -9,335 | -7,188 | -7,283 | -3,917 | -3,895 | -14,577 |
Other comprehensive income | ||||||||||||||||||||
Net unrealized gain on available-for-sale-securities | ||||||||||||||||||||
525 | -89 | -116 | 176 | 58 | 41 | -49 | 37 | 5 | 168 | -485 | -295 | 377 | -682 | 570 | 30 | 281 | - | 58 | -20 | - |
Cumulative effect adjustment resulting from ASU No. 2016-01 | ||||||||||||||||||||
- | - | - | - | - | - | - | - | -20,050 | - | - | - | - | - | - | - | - | - | - | - | - |
Total other comprehensive income | ||||||||||||||||||||
525 | -89 | -116 | 176 | 58 | -79 | -49 | 37 | 125 | 168 | -485 | -295 | 377 | -682 | 570 | 30 | 281 | - | 58 | -20 | - |
Comprehensive loss | ||||||||||||||||||||
-23,738 | -12,663 | -15,122 | 11,329 | -27,112 | -22,611 | -20,338 | -25,504 | -19,801 | -11,660 | -23,831 | -19,171 | -16,271 | -15,356 | -8,426 | -9,305 | -6,907 | -7,572 | -3,859 | -3,915 | -14,577 |
Net income (loss) per share, basic | ||||||||||||||||||||
- | - | - | 0.30 | - | - | - | -0.80 | - | - | - | - | - | - | - | - | - | - | - | - | - |
Net income (loss) per share, diluted | ||||||||||||||||||||
- | - | - | 0.29 | - | - | - | -0.80 | - | - | - | - | - | - | - | - | - | - | - | - | - |
Weighted-average common shares outstanding, basic | ||||||||||||||||||||
- | - | - | 36,610 | - | - | - | 31,976 | - | - | - | - | - | - | - | - | - | - | - | - | - |
Weighted-average common shares outstanding, diluted | ||||||||||||||||||||
- | - | - | 37,941 | - | - | - | 31,976 | - | - | - | - | - | - | - | - | - | - | - | - | - |
Reconciliation of net loss to net loss attributable to common stockholders: | ||||||||||||||||||||
Accretion of redeemable convertible preferred stock to redemption value | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1,328 | 2,594 | 2,452 | 999 |
Accrued dividends on series A preferred stock | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 206 | 403 | 399 | 237 |
Net loss attributable to common stockholders | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -7,188 | -8,817 | -6,914 | -6,746 | -15,813 |
Net loss per share, basic and diluted | ||||||||||||||||||||
-0.66 | - | -0.41 | - | -0.81 | - | -0.63 | - | -0.63 | -0.37 | -0.89 | -0.73 | -0.65 | -0.58 | -0.35 | -0.37 | -0.29 | 36.12 | -5.25 | -5.94 | -15.79 |
Weighted-average common shares outstanding, basic and diluted | ||||||||||||||||||||
36,963 | - | 36,742 | - | 33,353 | - | 32,191 | - | 31,759 | 29,312 | 26,164 | 25,946 | 25,791 | 25,530 | 25,374 | 25,228 | 25,076 | 13,311 | 1,317 | 1,135 | 1,001 |
ASU 2016-01 | ||||||||||||||||||||
Cumulative effect adjustment resulting from ASU No. 2016-01 | ||||||||||||||||||||
- | - | - | - | - | - | 0 | 0 | 120 | - | - | - | - | - | - | - | - | - | - | - | - |