| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Collaboration revenue | ||||||||||||||||||||
117,261 | 104,391 | 73,725 | 55,386 | 11,874 | 7,619 | 11,957 | 11,011 | 9,613 | 10,135 | 6,151 | 8,311 | 10,854 | 14,220 | 16,795 | 18,424 | 19,588 | 17,334 | 0 | 0 | 0 |
Operating expenses: | ||||||||||||||||||||
Research and development | ||||||||||||||||||||
127,198 | 119,735 | 100,097 | 86,952 | 74,883 | 64,905 | 61,319 | 64,248 | 63,041 | 62,260 | 61,657 | 52,405 | 47,589 | 42,249 | 38,745 | 34,917 | 30,888 | 27,679 | 0 | 0 | 0 |
General and administrative | ||||||||||||||||||||
36,882 | 36,335 | 34,700 | 32,846 | 36,286 | 33,809 | 30,919 | 29,252 | 22,006 | 19,738 | 17,853 | 16,281 | 14,619 | 13,270 | 12,946 | 12,051 | 11,593 | 9,909 | 0 | 0 | 0 |
Total operating expenses | ||||||||||||||||||||
164,080 | 156,070 | 134,797 | 119,798 | 111,169 | 98,714 | 92,238 | 93,500 | 85,047 | 81,998 | 79,510 | 68,686 | 62,208 | 55,519 | 51,691 | 46,968 | 42,481 | 37,588 | 0 | 0 | 0 |
Operating loss | ||||||||||||||||||||
-46,819 | -51,679 | -61,072 | -64,412 | -99,295 | -91,095 | -80,281 | -82,489 | -75,434 | -71,863 | -73,359 | -60,375 | -51,354 | -41,299 | -34,896 | -28,544 | -22,893 | -20,254 | 0 | 0 | 0 |
Other income: | ||||||||||||||||||||
Interest income | ||||||||||||||||||||
6,290 | 6,457 | 5,975 | 5,094 | 3,867 | 3,310 | 2,828 | 2,177 | 1,562 | 1,227 | -294 | 586 | 764 | 976 | 2,171 | 1,073 | 0 | - | 0 | 0 | - |
Other (expense) income | ||||||||||||||||||||
-161 | 1,625 | 1,542 | 480 | -104 | -683 | -280 | -478 | -58 | -62 | 433 | 616 | 763 | 182 | 0 | 0 | 0 | - | - | - | - |
Total other income | ||||||||||||||||||||
6,129 | 8,082 | 7,517 | 5,574 | 3,763 | 2,627 | 2,548 | 1,699 | 1,504 | 1,165 | 139 | 1,202 | 1,527 | 1,158 | 1,736 | 0 | 0 | - | 0 | - | - |
Loss before income taxes | ||||||||||||||||||||
- | - | -53,555 | -58,838 | - | -88,468 | -77,733 | -80,790 | -73,930 | -70,698 | -73,220 | -59,173 | -49,827 | -40,141 | -29,739 | 0 | 0 | - | 0 | - | - |
Income tax benefit | ||||||||||||||||||||
- | - | - | - | - | -180 | 0 | 0 | 0 | - | -334 | 0 | 0 | - | 0 | - | - | - | - | - | - |
Other financing expense | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 0 |
Total other expense, net | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 0 |
Net loss | ||||||||||||||||||||
-40,690 | -43,597 | -53,555 | -58,838 | -95,532 | -88,288 | -77,584 | -80,641 | -73,976 | -70,698 | -73,544 | -59,194 | -49,653 | -40,193 | -32,802 | -27,723 | -22,283 | -29,672 | 0 | 0 | 0 |
Other comprehensive income | ||||||||||||||||||||
Net unrealized gain on available-for-sale-securities | ||||||||||||||||||||
496 | 29 | 159 | 226 | 87 | 34 | 161 | -275 | -607 | -235 | -1,085 | -30 | 295 | 199 | 939 | 349 | 0 | - | 0 | 0 | - |
Cumulative effect adjustment resulting from ASU No. 2016-01 | ||||||||||||||||||||
- | - | - | - | - | - | - | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Total other comprehensive income | ||||||||||||||||||||
496 | 29 | 39 | 106 | -33 | 34 | 281 | -155 | -487 | -235 | -1,085 | -30 | 295 | 199 | 939 | 349 | 0 | - | 0 | 0 | - |
Comprehensive loss | ||||||||||||||||||||
-40,194 | -43,568 | -53,516 | -58,732 | -95,565 | -88,254 | -77,303 | -80,796 | -74,463 | -70,933 | -74,629 | -59,224 | -49,358 | -39,994 | -32,210 | -27,643 | -22,253 | -29,923 | 0 | 0 | 0 |
Net income (loss) per share, basic | ||||||||||||||||||||
- | - | - | 0.30 | - | - | - | -0.80 | - | - | - | - | - | - | - | - | - | - | - | - | - |
Net income (loss) per share, diluted | ||||||||||||||||||||
- | - | - | 0.29 | - | - | - | -0.80 | - | - | - | - | - | - | - | - | - | - | - | - | - |
Weighted-average common shares outstanding, basic | ||||||||||||||||||||
- | - | - | 36,610 | - | - | - | 31,976 | - | - | - | - | - | - | - | - | - | - | - | - | - |
Weighted-average common shares outstanding, diluted | ||||||||||||||||||||
- | - | - | 37,941 | - | - | - | 31,976 | - | - | - | - | - | - | - | - | - | - | - | - | - |
Reconciliation of net loss to net loss attributable to common stockholders: | ||||||||||||||||||||
Accretion of redeemable convertible preferred stock to redemption value | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 7,373 | 0 | 0 | 0 |
Accrued dividends on series A preferred stock | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1,245 | 0 | 0 | 0 |
Net loss attributable to common stockholders | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -29,665 | -38,290 | 0 | 0 | 0 |
Net loss per share, basic and diluted | ||||||||||||||||||||
-0.66 | - | -0.41 | - | -0.81 | - | -0.63 | - | -0.63 | -0.37 | -0.89 | -0.73 | -0.65 | -0.58 | -0.35 | -0.37 | -0.29 | 36.12 | -5.25 | -5.94 | -15.79 |
Weighted-average common shares outstanding, basic and diluted | ||||||||||||||||||||
36,963 | - | 36,742 | - | 33,353 | - | 32,191 | - | 31,759 | 29,312 | 26,164 | 25,946 | 25,791 | 25,530 | 25,374 | 25,228 | 25,076 | 13,311 | 1,317 | 1,135 | 1,001 |
ASU 2016-01 | ||||||||||||||||||||
Cumulative effect adjustment resulting from ASU No. 2016-01 | ||||||||||||||||||||
- | - | - | - | - | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - |