| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 |
|---|---|---|---|---|---|---|---|---|
Contract manufacturing | ||||||||
- | - | - | - | - | - | - | - | 1,745 |
Revenues | ||||||||
73,993 | 13,991 | 13,481 | 27,771 | 18,097 | 14,632 | 57,230 | 15,254 | 80,911 |
Costs and expenses: | ||||||||
Research and Development Expense | ||||||||
153,953 | 103,902 | 89,726 | 68,580 | 58,404 | 50,897 | 36,051 | 35,319 | 32,713 |
Selling, general and administrative | ||||||||
56,485 | 34,503 | 33,738 | 25,297 | 20,572 | 14,199 | 14,227 | 8,824 | 8,142 |
Litigation settlement | ||||||||
- | - | - | - | - | 5,000 | 0 | 0 | - |
Cost of contract manufacturing revenue | ||||||||
- | - | - | - | - | - | - | - | 1,500 |
Total costs and expenses | ||||||||
210,438 | 138,405 | 123,464 | 93,877 | 78,976 | 70,096 | 50,278 | 44,143 | 42,355 |
Loss from operations | ||||||||
-136,445 | -124,414 | -109,983 | -66,106 | -60,879 | -55,464 | 6,952 | -28,889 | 38,556 |
Other income (expense): | ||||||||
Other income (expense), net | ||||||||
819 | -52 | -992 | 7,262 | -3,527 | 5,044 | -26,797 | -2,255 | -485 |
Interest income | ||||||||
10,706 | 5,568 | 2,553 | 1,854 | 512 | 83 | 39 | 91 | 17 |
Interest expense | ||||||||
- | - | - | - | - | 922 | 2,092 | 1,529 | 1,822 |
Other income, net | ||||||||
11,525 | 5,516 | 1,561 | 9,116 | -3,015 | 4,205 | -28,850 | -3,693 | -2,290 |
Loss before income taxes | ||||||||
-124,920 | -118,898 | -108,422 | -56,990 | -63,894 | -51,259 | - | - | - |
Income tax provision | ||||||||
-62 | -27 | 32 | 24 | 0 | 0 | - | - | - |
Net Income (Loss) Attributable to Parent | ||||||||
-124,858 | -118,871 | -108,454 | -57,014 | -63,894 | -51,259 | -21,898 | -32,582 | 36,266 |
Net loss applicable to participating securities | ||||||||
- | - | - | - | - | - | - | - | 12,395 |
Net loss applicable to common stockholdersbasic and diluted | ||||||||
- | - | - | - | - | - | - | - | 2,114 |
Net income (loss) per share applicable to common stockholders: | ||||||||
Basic (in dollars per share) | ||||||||
- | - | - | - | - | - | - | - | 0.80 |
Diluted (in dollars per share) | ||||||||
- | - | - | - | - | - | - | - | 0.78 |
Weighted-average number of common shares used in computing net loss per share applicable to common stockholders: | ||||||||
Basic (in shares) | ||||||||
- | - | - | - | - | - | - | - | 2,328 |
Diluted (in shares) | ||||||||
- | - | - | - | - | - | - | - | 2,716 |
Other comprehensive (loss) income: | ||||||||
Accretion of dividends, interest, redemption value and issuance costs on redeemable convertible preferred stock | ||||||||
- | - | - | - | - | - | 19,870 | 27,061 | 21,757 |
Gain on extinguishment of redeemable convertible preferred stock | ||||||||
- | - | - | - | - | - | 2,765 | 0 | - |
Net loss applicable to participating securities | ||||||||
- | - | - | - | - | - | - | - | 12,645 |
Net (loss) income applicable to common stockholders-basic and diluted | ||||||||
- | - | - | - | - | - | -39,003 | -59,643 | 1,864 |
Net (loss) income | ||||||||
-124,858 | -118,871 | -108,454 | -57,014 | -63,894 | - | -21,898 | -32,582 | 36,266 |
Other Comprehensive Income (Loss), Securities, Available-for-Sale, Unrealized Holding Gain (Loss) Arising During Period, after Tax | ||||||||
583 | 335 | -470 | -205 | -220 | 0 | 0 | - | - |
Comprehensive loss | ||||||||
-124,275 | -118,536 | -108,924 | -57,219 | -64,114 | -51,259 | -21,898 | -32,582 | 36,266 |
Net loss per share- basic and diluted (in dollars per share) | ||||||||
-2.38 | -2.59 | -2.68 | -1.52 | -1.92 | -1.63 | -4.15 | -24.84 | - |
Weighted-average number of common shares used in computing net loss per share- basic and diluted (in shares) | ||||||||
52,453 | 45,898 | 40,420 | 37,430 | 33,303 | 31,515 | 9,407 | 2,401 | - |
License and milestone | ||||||||
Revenue | ||||||||
60,000 | 0 | 541 | 15,549 | 1,184 | 1,673 | 43,948 | 9,696 | 74,406 |
Cost-sharing, net | ||||||||
Revenues | ||||||||
13,993 | 13,991 | 12,940 | 12,221 | 16,913 | 12,959 | 13,282 | 5,558 | 4,760 |