| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 | Dec'14 | Sep'14 | Jun'14 | Mar'14 | Dec'13 | Sep'13 | Jun'13 | Mar'13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Revenue | ||||||||||||||||||||||||||||
Collaborations, licenses, milestones, and royalties | ||||||||||||||||||||||||||||
77,146 | 156,700 | 182,239 | 0 | 0 | - | 0 | - | - | 46,200 | 43,940 | 51,761 | 105,268 | 109,020 | 102,834 | 98,516 | 33,523 | 27,762 | 11,672 | 9,017 | 8,827 | 9,520 | 5,600 | 7,914 | 11,011 | 10,172 | 0 | 0 | 0 |
Operating expenses | ||||||||||||||||||||||||||||
Research and development | ||||||||||||||||||||||||||||
124,350 | 118,590 | 118,381 | 109,564 | 99,597 | 97,501 | 90,769 | 89,224 | 82,811 | 71,772 | 64,735 | 59,396 | 56,885 | 51,872 | 49,389 | 45,902 | 38,970 | 34,140 | 28,315 | 22,686 | 19,493 | 18,516 | 17,607 | 16,817 | 16,668 | 17,000 | 0 | 0 | 0 |
General and administrative | ||||||||||||||||||||||||||||
25,993 | 24,286 | 23,053 | 24,222 | 23,422 | 22,472 | 21,382 | 18,119 | 17,252 | 17,501 | 16,182 | 15,017 | 13,969 | 13,108 | 13,439 | 13,665 | 13,146 | 11,960 | 10,483 | 9,432 | 8,502 | 7,461 | 6,810 | 5,470 | 4,669 | 3,692 | 0 | 0 | 0 |
Total operating expenses | ||||||||||||||||||||||||||||
150,343 | 142,876 | 141,434 | 133,786 | 123,019 | 119,973 | 112,151 | 107,343 | 100,063 | 89,273 | 80,917 | 74,413 | 70,854 | 64,980 | 62,828 | 59,567 | 52,116 | 46,100 | 38,798 | 32,118 | 27,995 | 25,977 | 24,417 | 22,287 | 21,337 | 20,692 | 0 | 0 | 0 |
Income (loss) from operations | ||||||||||||||||||||||||||||
-73,197 | 13,824 | 23,314 | 38,241 | 29,523 | -79,370 | -52,962 | -77,193 | -57,413 | -43,123 | -36,977 | -22,652 | 34,414 | 44,040 | 40,006 | 38,949 | -18,593 | -18,338 | -27,126 | -23,101 | -19,168 | -16,457 | -18,817 | -14,373 | -10,326 | -10,520 | 0 | 0 | 0 |
Other income (expenses) | ||||||||||||||||||||||||||||
Interest income, net | ||||||||||||||||||||||||||||
13,772 | 13,619 | 13,007 | 11,950 | 10,818 | 9,086 | 7,320 | 5,723 | 4,278 | 4,181 | 3,925 | 3,459 | 2,789 | 2,091 | 1,448 | 1,143 | 1,065 | 744 | 604 | 332 | 53 | 33 | 38 | 40 | 31 | 14 | 0 | 0 | 0 |
Interest expense | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | -10 | -3 | 21 | 40 | 42 | 36 | 13 | 14 | 12 | 11 | 9 | 8 | 5 | 554 | 1,213 | 0 | 0 | 0 |
Other expense, net | ||||||||||||||||||||||||||||
-2,407 | -256 | -131 | -277 | -312 | -125 | -147 | 26 | 0 | - | 0 | 0 | - | 6 | 12 | -159 | 0 | - | 0 | 0 | - | - | 0 | 0 | - | 16 | 0 | 0 | 0 |
Loss on settlement of convertible promissory notes | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | - |
Total other income, net | ||||||||||||||||||||||||||||
11,365 | 13,363 | 12,876 | 11,673 | 10,506 | 8,961 | 7,030 | 5,632 | 4,276 | 4,174 | 4,023 | 3,502 | 2,795 | 2,076 | 1,592 | 1,287 | 1,047 | 746 | 428 | 162 | 53 | 35 | 41 | 40 | -49,072 | -49,739 | 0 | 0 | 0 |
Net income (loss) before income tax expense | ||||||||||||||||||||||||||||
-61,832 | 27,187 | 36,190 | 49,914 | 40,029 | -70,409 | -45,932 | -71,561 | -53,137 | -38,949 | -32,954 | -19,150 | 37,209 | 46,116 | 23,804 | 23,611 | 0 | - | 0 | 0 | - | - | - | - | - | - | - | - | - |
Income tax expense | ||||||||||||||||||||||||||||
- | 312 | 0 | 0 | 0 | - | - | - | - | -463 | 463 | -308 | 1,161 | 991 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Net income (loss) | ||||||||||||||||||||||||||||
-61,244 | 26,875 | 35,590 | 48,964 | 39,129 | -70,409 | -44,846 | -70,648 | -52,504 | -38,486 | -33,417 | -18,842 | 36,048 | 45,125 | 40,447 | 38,487 | -17,546 | -17,592 | -26,698 | -22,939 | -19,115 | -16,422 | -18,776 | -14,333 | -59,398 | -60,259 | 0 | 0 | 0 |
Net deemed contribution on exchange of preferred stock | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 0 | - |
Net income (loss) attributable to common stockholders | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 0 | - |
Other comprehensive income (loss) | ||||||||||||||||||||||||||||
Net unrealized gain (loss) on marketable securities | ||||||||||||||||||||||||||||
711 | 2,132 | 3,774 | 3,637 | 2,546 | 837 | -1,241 | -768 | -1,005 | -367 | -847 | -1,456 | -1,299 | -925 | -244 | 306 | 138 | -516 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Comprehensive income (loss) | ||||||||||||||||||||||||||||
-60,533 | 29,007 | 39,364 | 52,601 | 41,675 | -69,572 | -46,087 | -71,416 | -53,509 | -38,853 | -34,264 | -20,298 | 34,749 | 44,200 | 40,203 | 38,793 | -17,408 | -18,108 | -31,633 | 0 | 0 | - | 0 | - | - | - | - | - | - |
Net income (loss) per share attributable to common stockholders: | ||||||||||||||||||||||||||||
Basic and diluted net loss (in dollars per share) | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | -0.17 | -0.33 | - | - | - | -0.16 | - | - | - | - | - | - | - | - | - | - | - | - |
Basic net income (loss) (in dollars per share) | ||||||||||||||||||||||||||||
-0.14 | -0.48 | -0.18 | -0.28 | 1.42 | -0.29 | 0.06 | -0.46 | -0.62 | - | -0.48 | - | - | - | -0.20 | 1.16 | - | - | -0.25 | -0.22 | - | - | - | - | - | - | -57.87 | 1,341.67 | - |
Diluted net income (loss) (in dollars per share) | ||||||||||||||||||||||||||||
-0.14 | -0.46 | -0.18 | -0.28 | 1.38 | -0.28 | 0.05 | -0.46 | -0.62 | - | -0.48 | - | - | - | -0.20 | 1.13 | - | - | -0.25 | -0.22 | - | - | - | - | - | - | -57.87 | -3.88 | - |
Weighted average shares used to compute net income (loss) per share attributable to common stockholders: | ||||||||||||||||||||||||||||
Comprehensive loss | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 0 | - | - | - | - |
Basic and diluted net loss per common share (in dollars per share) | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -0.19 | - | -0.20 | -0.16 | -0.12 | - | - | - | -63.78 |
Basic and diluted (in shares) | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | 46,767 | 46,598 | - | - | - | 40,626 | - | - | - | 34,297 | - | 31,395 | 31,372 | 31,360 | - | - | - | 72 |
Basic (in shares) | ||||||||||||||||||||||||||||
56,946 | 56,780 | 56,643 | 56,399 | 56,302 | 56,361 | 55,974 | 55,678 | 47,753 | - | 46,929 | - | - | - | 41,033 | 40,800 | - | - | 40,473 | 40,389 | - | - | - | - | - | - | 72 | 72 | - |
Diluted (in shares) | ||||||||||||||||||||||||||||
56,946 | 62,819 | 56,643 | 56,399 | 58,009 | 54,022 | 58,313 | 55,678 | 47,753 | - | 46,929 | - | - | - | 41,033 | 41,738 | - | - | 40,473 | 40,389 | - | - | - | - | - | - | 72 | 12,902 | - |