| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 |
|---|---|---|---|---|---|---|---|---|
Cash flows from operating activities | ||||||||
Cash flows from operating activities | ||||||||
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest | ||||||||
-323,916 | -514,706 | -126,820 | -190,274 | -87,994 | -85,616 | -40,908 | -81,874 | -85,280 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||
Depreciation and amortization | ||||||||
24,896 | 33,112 | 31,145 | 24,572 | 17,743 | 10,415 | 7,205 | 7,984 | 4,338 |
Loss on disposals of assets, net | ||||||||
-3,071 | -20,928 | -3,124 | -666 | -633 | -208 | -349 | -101 | -1 |
Impairment loss | ||||||||
120,489 | 60,504 | 16,773 | 0 | 0 | - | - | - | - |
Reacquisition of in-process research and development | ||||||||
0 | 236,748 | 0 | 0 | - | - | - | - | - |
Equity Securities and Preferred Stock, Unrealized and Realized Appreciation (Depreciation) | ||||||||
7,833 | -30,200 | 2,586 | -58,894 | 66,876 | -10,469 | 10,443 | -6,290 | -2,675 |
Noncash dividend income | ||||||||
48 | 14,841 | 16,756 | 7,421 | 0 | 0 | - | - | - |
Amortization of discounts on investments, net | ||||||||
1,005 | 771 | -411 | -1,070 | -642 | -1,357 | -716 | 0 | - |
Collaboration revenue recognized upon achievement of milestone | ||||||||
- | - | - | - | - | - | - | 3,591 | - |
Income (Loss) from Equity Method Investments | ||||||||
-6,730 | -11,608 | -14,283 | -21,120 | -8,944 | -5,260 | -606 | -274 | - |
Gain on previously held equity investment | ||||||||
- | - | - | - | - | - | 7,415 | 0 | - |
Stock-based compensation expense | ||||||||
18,950 | 36,296 | 41,576 | 42,202 | 38,667 | 21,849 | 2,921 | 1,458 | 983 |
Contribution of services by shareholder | ||||||||
- | - | - | - | - | 1,991 | 1,550 | 1,550 | 210 |
Shares issued as payment for services | ||||||||
10,446 | 10,695 | 11,118 | 10,777 | 2,169 | 486 | 124 | - | - |
Shares issued to nonemployee members of the Board of Directors | ||||||||
- | - | - | - | - | - | - | 93 | 9 |
Shares issued as consideration for license agreement | ||||||||
- | - | - | - | 59,579 | 0 | 0 | - | - |
Accounts Receivable, Credit Loss Expense (Reversal) | ||||||||
3,242 | 1,779 | 1,217 | 1,963 | 1,757 | 565 | 0 | 0 | - |
Accretion of debt discount and amortization of deferred financing costs | ||||||||
9,459 | 4,378 | 0 | 0 | - | - | - | - | - |
Deferred Income Tax Expense (Benefit) | ||||||||
-3,674 | -21,278 | -2,528 | -3,467 | 1,117 | 0 | 0 | - | - |
Other noncash items | ||||||||
-837 | -1,093 | 517 | -1,662 | -460 | -723 | 75 | 0 | - |
Changes in operating assets and liabilities: | ||||||||
Restricted cash | ||||||||
- | - | - | - | 0 | 0 | - | - | - |
Receivables: | ||||||||
Trade | ||||||||
262 | 2,698 | -740 | -2,588 | 12,138 | -4,332 | 644 | 121 | -33 |
Related parties | ||||||||
-967 | -11,003 | -631 | -6,804 | 11,042 | 6,117 | 4,967 | 93 | 239 |
Notes | ||||||||
- | - | - | 42 | 0 | 1 | 0 | 0 | - |
Other | ||||||||
656 | 542 | -661 | -271 | -5,286 | -15 | 542 | -1,015 | 400 |
Inventory | ||||||||
-4,100 | 478 | -663 | -3,807 | 774 | 7,313 | 0 | 0 | - |
Prepaid expenses and other | ||||||||
2,262 | -1,006 | -492 | 932 | 2,729 | 465 | 347 | 413 | 772 |
Other assets | ||||||||
-333 | -652 | 1,017 | -2,189 | 2,119 | -80 | 18 | -658 | 614 |
Accounts payable | ||||||||
-5,349 | 4,680 | -3,402 | 3,618 | -3,263 | 1,266 | -43 | -1,229 | -388 |
Accrued compensation and benefits | ||||||||
5,186 | 4,385 | -1,466 | -12,402 | 10,491 | 1,587 | 1,301 | 2,441 | -2,249 |
Other accrued liabilities | ||||||||
-5,516 | 356 | 3,007 | 9,002 | 1,593 | -586 | 1,558 | -806 | 1,204 |
Deferred revenue | ||||||||
7,423 | -38,578 | -75,337 | -25,481 | 74,434 | 20,934 | -4,368 | 4,997 | -2,245 |
Deferred consideration | ||||||||
0 | 0 | -313 | -630 | -943 | 0 | 0 | - | - |
Lease liabilities | ||||||||
-995 | - | - | - | - | - | - | - | - |
Related party payables | ||||||||
45 | -52 | -147 | 310 | -64 | -1,137 | 6 | -180 | -215 |
Other long-term liabilities | ||||||||
-585 | 281 | 1,328 | 146 | 96 | -160 | -249 | -83 | 1,191 |
Net cash used in operating activities | ||||||||
-135,927 | -124,240 | -103,720 | -48,988 | 35,669 | -19,858 | -53,683 | -61,529 | -81,758 |
Cash flows from investing activities | ||||||||
Purchases of investments | ||||||||
55,073 | 178,681 | 0 | 75,246 | 181,572 | 60,478 | 233,979 | 2 | 188 |
Sales and maturities of investments | ||||||||
166,495 | 65,975 | 174,542 | - | - | - | - | - | - |
Sales of investments | ||||||||
- | - | - | - | - | 9,100 | 0 | 0 | - |
Maturities of investments | ||||||||
- | - | - | 101,987 | 88,000 | 122,992 | 44,996 | 0 | - |
Purchases of preferred stock and warrants | ||||||||
0 | 0 | 1,161 | 2,308 | 17,080 | 19,496 | 28,650 | - | - |
Proceeds from sales of equity securities | ||||||||
23,456 | 217 | 235 | 280 | 0 | 0 | - | - | - |
Purchases of equity securities | ||||||||
- | - | - | - | - | - | - | 10,000 | 22,628 |
Acquisitions of businesses, net of cash received | ||||||||
0 | 920 | -2,054 | 0 | 123,928 | 67,577 | -517 | 0 | 28,662 |
Investments in affiliates | ||||||||
3,713 | 16,582 | 11,189 | 11,542 | 13,442 | 2,875 | 5,000 | 6,000 | - |
Decrease in cash from deconsolidation of subsidiary | ||||||||
7,244 | 0 | 0 | - | - | - | - | - | - |
Return of investment in affiliate | ||||||||
125 | 2,598 | 0 | 0 | - | - | - | - | - |
Cash inflows (outflows) in asset acquisition | ||||||||
0 | 15,500 | -14,219 | -7,244 | 0 | 0 | - | - | - |
Purchases of property, plant and equipment | ||||||||
37,883 | 41,587 | 46,666 | 31,629 | 12,749 | 6,371 | 1,527 | 7,491 | 13,003 |
Proceeds from sale of assets | ||||||||
688 | 2,267 | 1,636 | 274 | 626 | 176 | 480 | 23 | 84 |
Issuances of notes receivable | ||||||||
0 | 0 | 2,400 | 2,964 | 600 | 1,500 | 1,000 | 200 | - |
Proceeds from repayment of notes receivable | ||||||||
0 | 0 | 1,500 | 0 | 1,500 | 0 | 500 | 34 | - |
Proceeds from related party notes receivable | ||||||||
- | - | - | - | - | - | - | - | 300 |
Net cash provided by (used in) investing activities | ||||||||
86,851 | -151,213 | 104,332 | -28,392 | -259,245 | -26,029 | -223,663 | -23,636 | -64,097 |
Cash flows from financing activities | ||||||||
Cash flows from financing activities | ||||||||
Proceeds from issuance of Series F redeemable convertible preferred shares | ||||||||
- | - | - | - | - | - | 150,000 | - | - |
Proceeds from IPO, net of issuance costs | ||||||||
- | - | - | - | - | - | 168,801 | 0 | - |
Proceeds from issuance of shares in a private placement | ||||||||
0 | 0 | 13,686 | 0 | 0 | 25,000 | 0 | 0 | - |
Proceeds from issuance of shares and warrants in public offering, net of issuance costs | ||||||||
6,611 | 87,990 | 0 | 0 | 328,234 | 0 | 0 | - | - |
Acquisitions of noncontrolling interests | ||||||||
0 | 0 | 913 | 0 | 1,566 | 0 | 0 | - | - |
Settlement of fractional shares | ||||||||
- | - | - | - | - | - | 5 | 0 | - |
Advances from lines of credit | ||||||||
11,757 | 4,561 | 5,906 | 5,075 | 15,232 | 4,676 | 0 | 0 | - |
Repayments of advances from lines of credit | ||||||||
10,301 | 4,328 | 6,493 | 4,816 | 16,944 | 6,494 | 0 | 0 | - |
Proceeds from issuance of subscriptions payable | ||||||||
- | - | - | - | - | - | - | - | 7,440 |
Proceeds from short-term borrowings | ||||||||
- | - | - | - | - | - | - | - | 15,000 |
Payments of capital lease obligations | ||||||||
- | - | - | - | - | - | - | 77 | 115 |
Proceeds from long-term debt, net of issuance costs | ||||||||
376 | 219,859 | 325 | 547 | 81 | 268 | 493 | 0 | - |
Payments of long-term debt | ||||||||
618 | 623 | 519 | 1,201 | 1,564 | 679 | 104 | 0 | - |
Payments of deferred consideration for acquisitions | ||||||||
0 | 0 | 8,678 | 6,705 | 6,252 | 0 | 0 | - | - |
Proceeds from stock option and warrant exercises | ||||||||
313 | 2,336 | 980 | 19,165 | 14,462 | 1,489 | 414 | 473 | 184 |
Payment of stock issuance costs | ||||||||
0 | 0 | 10 | 0 | 0 | 256 | 3,148 | 16 | 2,675 |
Net cash provided by financing activities | ||||||||
8,138 | 309,795 | 4,284 | 12,065 | 331,683 | 24,004 | 316,451 | 75,940 | 148,111 |
Effect of exchange rate changes on cash, cash equivalents, and restricted cash | ||||||||
-810 | 295 | 1,055 | -873 | 209 | -160 | 1 | 0 | - |
Net decrease in cash, cash equivalents, and restricted cash | ||||||||
-41,748 | 34,637 | 5,951 | -66,188 | 108,316 | -22,043 | 39,106 | -9,225 | 2,256 |
Supplemental Cash Flow Information [Abstract] | ||||||||
Cash paid during the period for interest | ||||||||
3,751 | 3,868 | 617 | 964 | 1,195 | 158 | 51 | 12 | 18 |
Cash paid during the period for income taxes | ||||||||
50 | 216 | 566 | 10 | 1,165 | 0 | 0 | - | - |
Significant noncash activities | ||||||||
Accretion of dividends on redeemable convertible preferred shares | ||||||||
- | - | - | - | - | - | 18,391 | 21,994 | 13,868 |
Stock received as consideration for collaboration agreements | ||||||||
4,530 | 0 | 0 | 18,766 | 9,149 | 14,246 | 19,303 | 21,979 | 19,144 |
Preferred stock received as consideration for collaboration amendments | ||||||||
- | - | - | 120,000 | 0 | 0 | - | - | - |
Receivables converted to preferred stock | ||||||||
0 | 0 | 3,385 | 0 | 0 | - | - | - | - |
Stock and warrants issued in business combinations | ||||||||
0 | 0 | 16,997 | 0 | 126,863 | 51,682 | 0 | 0 | - |
Stock received as consideration upon achievement of milestone | ||||||||
- | - | - | - | - | - | - | 18,330 | - |
Stock issued to acquire noncontrolling interests | ||||||||
0 | 0 | 5,082 | 0 | 9,412 | 0 | 0 | - | - |
Stock issued for reacquired in-process research and development | ||||||||
0 | 159,323 | 0 | 0 | - | - | - | - | - |
Stock issued in asset acquisition | ||||||||
- | - | - | 4,401 | 0 | 0 | - | - | - |
Long-term debt issued to a related party in an asset acquisition | ||||||||
0 | 30,000 | 0 | 0 | - | - | - | - | - |
Contingent consideration assumed in asset acquisition | ||||||||
- | - | - | 3,660 | 0 | 0 | - | - | - |
Stock issued as payment for contingent consideration | ||||||||
- | - | - | 1,583 | 0 | 0 | - | - | - |
Noncash dividend to shareholders | ||||||||
0 | 0 | 22,385 | 0 | 172,419 | 0 | 0 | - | - |
Deferred consideration payable related to acquisition | ||||||||
- | - | - | - | 1,992 | 20,115 | 0 | 0 | - |
Equity instruments issued in acquisitions | ||||||||
- | - | - | - | - | - | - | - | 4,237 |
Accrued investment in affiliate | ||||||||
- | - | - | - | - | - | 1,500 | 0 | - |
Purchases of property and equipment included in accounts payable and other accrued liabilities | ||||||||
694 | 2,267 | 2,257 | 652 | 782 | 790 | 361 | 24 | 2,231 |
Cash, cash equivalents, and restricted cash | ||||||||
Purchases of equipment financed through debt | ||||||||
0 | 234 | 0 | 0 | - | - | - | - | - |
Receivable recorded in anticipation of dissolution of affiliate | ||||||||
0 | 0 | 2,598 | 0 | 0 | - | - | - | - |
Transfer of inventory to breeding stock | ||||||||
- | - | - | 1,191 | 0 | 0 | - | - | - |