| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 | Dec'14 | Sep'14 | Jun'14 | Mar'14 | Dec'13 | Sep'13 | Jun'13 | Mar'13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cash flows from operating activities | ||||||||||||||||||||||||||||
Cash flows from operating activities | ||||||||||||||||||||||||||||
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest | ||||||||||||||||||||||||||||
-317,778 | -323,916 | -496,423 | -501,535 | -529,433 | -514,706 | -206,929 | -189,019 | -141,852 | -126,820 | -137,787 | -126,962 | -157,331 | -190,274 | -178,637 | -187,655 | -179,118 | -87,994 | -36,787 | -51,620 | -63,061 | -85,616 | -116,566 | -47,713 | -1,297 | -40,908 | 0 | 0 | 0 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||||||||||||||||||||||
Depreciation and amortization | ||||||||||||||||||||||||||||
23,129 | 24,896 | 26,639 | 28,921 | 31,307 | 33,112 | 33,448 | 33,135 | 32,127 | 31,145 | 29,796 | 27,789 | 26,324 | 24,572 | 23,198 | 22,059 | 19,842 | 17,743 | 15,747 | 14,000 | 12,159 | 10,415 | 8,614 | 7,284 | 7,139 | 7,205 | 0 | 0 | 0 |
Loss on disposals of assets, net | ||||||||||||||||||||||||||||
-2,795 | -3,071 | -18,693 | -16,629 | -21,105 | -20,928 | -5,923 | -7,742 | -2,874 | -3,124 | -1,680 | -1,408 | -1,047 | -666 | -411 | -657 | -726 | -633 | -557 | -328 | -293 | -208 | 0 | 0 | 0 | - | - | - | - |
Gain on sale of discontinued operations | ||||||||||||||||||||||||||||
0 | - | - | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Loss on release of cumulative foreign currency translation adjustments to loss from discontinued operations | ||||||||||||||||||||||||||||
0 | - | - | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Unrealized and realized (appreciation) depreciation on equity securities and preferred stock, net | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | 0 | 0 | - | - | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Equity Securities and Preferred Stock, Unrealized and Realized Appreciation (Depreciation) | ||||||||||||||||||||||||||||
7,657 | 7,833 | -1 | -4,220 | -29,034 | -30,200 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | -10,469 | -44,205 | 20,223 | 61,734 | 10,443 | 0 | 0 | 0 |
Noncash dividend income | ||||||||||||||||||||||||||||
- | - | - | - | - | 14,841 | 19,028 | 18,690 | 17,713 | 16,756 | 16,048 | 15,401 | 11,347 | 7,421 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Unrealized (appreciation) depreciation on equity securities | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | - | - | - | - | - | - | - | - |
Amortization of discounts on investments, net | ||||||||||||||||||||||||||||
886 | 1,005 | 1,445 | 1,464 | 1,123 | 771 | 275 | -81 | -213 | -411 | -619 | -802 | -948 | -1,070 | -1,206 | -1,044 | -838 | -642 | -534 | -761 | -1,067 | -1,357 | -1,586 | -1,457 | -1,130 | -716 | 0 | 0 | 0 |
Income (Loss) from Equity Method Investments | ||||||||||||||||||||||||||||
-5,479 | -6,730 | -6,762 | -7,985 | -10,788 | -11,608 | -12,890 | -13,013 | -11,796 | -14,283 | -15,442 | -18,704 | -20,424 | -21,120 | -19,330 | -15,504 | -12,631 | -8,944 | -8,315 | -7,505 | -6,680 | -5,260 | -3,726 | -2,107 | -752 | -606 | 0 | 0 | 0 |
Gain on previously held equity investment | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 7,415 | 0 | 0 | 0 |
Stock-based compensation expense | ||||||||||||||||||||||||||||
14,268 | 18,950 | 22,494 | 25,203 | 33,988 | 36,296 | 37,967 | 41,892 | 45,044 | 41,576 | 43,520 | 42,255 | 36,908 | 42,202 | 42,774 | 40,367 | 41,596 | 38,667 | 33,501 | 29,366 | 28,334 | 21,849 | 15,952 | 12,347 | 6,308 | 2,921 | 0 | 0 | 0 |
Contribution of services by shareholder | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1,991 | 1,872 | 1,752 | 1,632 | 1,550 | 0 | 0 | 0 |
Shares issued as payment for services | ||||||||||||||||||||||||||||
10,545 | 10,446 | 10,278 | 10,896 | 8,585 | 10,695 | 11,082 | 10,895 | 11,144 | 11,118 | 10,933 | 10,798 | 10,609 | 10,777 | 9,973 | 7,378 | 4,772 | 2,169 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Shares issued to nonemployee members of the Board of Directors | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 0 | 0 | - | 0 | 0 | 0 |
Shares issued as consideration for license agreement | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 59,579 | 59,579 | 59,579 | 59,579 | 0 | 0 | 0 | 0 | - | - | - | - |
Accounts Receivable, Credit Loss Expense (Reversal) | ||||||||||||||||||||||||||||
3,701 | 3,242 | 969 | 1,334 | 1,625 | 1,779 | 1,721 | 1,424 | 1,426 | 1,217 | 1,447 | 1,362 | 1,132 | 1,963 | 1,804 | 1,956 | 2,204 | 1,757 | 2,053 | 1,549 | 958 | 565 | 0 | 0 | 0 | - | - | - | - |
Accretion of debt discount and amortization of deferred financing costs | ||||||||||||||||||||||||||||
9,763 | 9,459 | 9,224 | 8,910 | 6,591 | 4,378 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Deferred Income Tax Expense (Benefit) | ||||||||||||||||||||||||||||
-3,166 | -3,674 | -3,391 | -17,170 | -17,712 | -21,278 | -19,569 | -6,098 | -5,964 | -2,528 | -2,794 | -2,327 | -1,917 | -3,467 | -2,224 | -2,494 | -1,866 | 1,117 | 374 | 952 | 795 | 0 | 0 | 0 | 0 | - | - | - | - |
Other noncash items | ||||||||||||||||||||||||||||
-841 | -837 | -3,742 | -4,054 | -1,201 | -1,093 | -1,966 | -3,294 | 244 | 517 | 1,445 | 2,335 | -1,323 | -1,662 | -1,414 | -309 | -389 | -460 | -784 | -1,194 | -952 | -723 | 0 | 0 | 0 | - | - | - | 0 |
Receivables: | ||||||||||||||||||||||||||||
Trade | ||||||||||||||||||||||||||||
1,130 | 262 | 2,856 | 2,802 | 3,248 | 2,698 | 1,352 | 1,197 | -665 | -740 | -2,961 | -3,349 | -1,497 | -2,588 | -1,994 | -112,915 | 8,301 | 12,138 | 11,125 | 123,166 | -3,425 | -4,332 | -2,848 | 550 | 516 | 644 | 0 | 0 | 0 |
Related parties | ||||||||||||||||||||||||||||
592 | -967 | -6,108 | -1,407 | -7,858 | -11,003 | -7,789 | -8,845 | -10,354 | -631 | 1,707 | 4,334 | 5,768 | -6,804 | -7,578 | 2,052 | 6,271 | 11,042 | 12,131 | 2,885 | 2,551 | 6,117 | 5,928 | 7,497 | 2,503 | 4,967 | 0 | 0 | 0 |
Notes | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | 42 | 43 | 4 | -4 | 0 | 0 | 21 | 17 | 1 | 0 | 0 | 0 | - | - | - | - |
Other | ||||||||||||||||||||||||||||
-438 | 656 | -829 | 193 | -315 | 542 | 785 | 52 | 413 | -661 | -427 | -305 | -1,298 | -271 | 723 | -5,702 | -5,051 | -5,286 | -6,446 | -346 | -186 | -15 | 11 | 479 | 664 | 542 | 0 | 0 | 0 |
Inventory | ||||||||||||||||||||||||||||
-3,921 | -4,100 | -1,720 | -2,186 | -672 | 478 | 178 | 905 | 1,164 | -663 | -2,542 | -3,736 | -4,380 | -3,807 | -458 | -2,509 | -1,093 | 774 | 4,444 | 8,525 | 7,695 | 7,313 | 0 | 0 | 0 | - | - | - | - |
Prepaid expenses and other | ||||||||||||||||||||||||||||
1,013 | 2,262 | 2,803 | 233 | 378 | -1,006 | -497 | -1,305 | -1,344 | -492 | 463 | 1,760 | 865 | 932 | -291 | -239 | 2,294 | 2,729 | 3,791 | 1,899 | 759 | 465 | 398 | 1,329 | 454 | 347 | 0 | 0 | 0 |
Right-of-use assets | ||||||||||||||||||||||||||||
- | - | - | - | - | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Other assets | ||||||||||||||||||||||||||||
-327 | -333 | -27 | 652 | -712 | -652 | -184 | 598 | 538 | 1,017 | 562 | 825 | -824 | -2,189 | -3,832 | -5,454 | 64 | 2,119 | 3,826 | 4,867 | 1,173 | -80 | -129 | -7,600 | 23 | 18 | 0 | 0 | 0 |
Accounts payable | ||||||||||||||||||||||||||||
-5,029 | -5,349 | 979 | 1,462 | 4,207 | 4,680 | -377 | -78 | -3,176 | -3,402 | -3,039 | -3,008 | 235 | 3,618 | 3,198 | -304 | -1,542 | -3,263 | -1,097 | 802 | 1,422 | 1,266 | -1,422 | -426 | 539 | -43 | 0 | 0 | 0 |
Accrued compensation and benefits | ||||||||||||||||||||||||||||
5,033 | 5,186 | -12,641 | -3,559 | -2,254 | 4,385 | 12,804 | 4,885 | 2,461 | -1,466 | -1,110 | -1,613 | -705 | -12,402 | -3,405 | -3,151 | 15 | 10,491 | 6,937 | 6,833 | 3,770 | 1,587 | 2,013 | 691 | -1,191 | 1,301 | 0 | 0 | 0 |
Other accrued liabilities | ||||||||||||||||||||||||||||
-2,361 | -5,516 | -6,886 | -6,334 | -3,300 | 356 | 3,044 | -155 | 465 | 3,007 | 2,785 | 6,192 | 4,347 | 9,002 | 8,041 | 5,561 | 5,107 | 1,593 | 1,557 | 1,675 | 390 | -586 | 1,038 | 97 | 1,750 | 1,558 | 0 | 0 | 0 |
Deferred revenue | ||||||||||||||||||||||||||||
-4,344 | 7,423 | -10,529 | -14,040 | -27,625 | -38,578 | -63,049 | -65,191 | -71,949 | -75,337 | -46,663 | -45,197 | -41,542 | -25,481 | 7,935 | 7,447 | 80,105 | 74,434 | 54,698 | 61,186 | -4,871 | 20,934 | 20,359 | 13,978 | 18,760 | -4,368 | 0 | 0 | 0 |
Lease liabilities | ||||||||||||||||||||||||||||
-1,077 | -995 | 0 | 0 | 0 | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Related party payables | ||||||||||||||||||||||||||||
-1,784 | 45 | 153 | 214 | 2,029 | -52 | -670 | -630 | -473 | -147 | 187 | 263 | 263 | 310 | 482 | -57,103 | 300 | -64 | -1,012 | 56,243 | -1,246 | -1,137 | -221 | 85 | -252 | 6 | 0 | 0 | 0 |
Other long-term liabilities | ||||||||||||||||||||||||||||
- | - | - | - | - | 281 | 310 | 937 | 1,306 | 1,328 | 1,291 | 649 | 323 | 146 | 54 | 14 | -82 | 96 | 242 | 156 | -13 | -160 | -333 | -367 | -164 | -249 | 0 | 0 | 0 |
Net cash used in operating activities | ||||||||||||||||||||||||||||
-120,436 | -135,927 | -141,147 | -142,819 | -137,586 | -124,240 | -120,758 | -113,948 | -108,919 | -103,720 | -87,048 | -80,769 | -70,068 | -48,988 | -19,448 | 49,178 | 45,101 | 35,669 | 14,287 | -45,245 | -42,378 | -19,858 | -21,032 | -30,241 | -29,925 | -53,683 | 0 | 0 | 0 |
Cash flows from investing activities | ||||||||||||||||||||||||||||
Purchases of investments | ||||||||||||||||||||||||||||
174,340 | 55,073 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Sales and maturities of investments | ||||||||||||||||||||||||||||
0 | - | - | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Maturities of investments | ||||||||||||||||||||||||||||
- | - | - | - | - | - | 0 | 0 | 135,542 | - | 166,300 | 148,000 | 128,987 | 101,987 | 89,987 | 81,987 | 82,000 | 88,000 | 94,747 | 97,245 | 111,743 | 122,992 | 0 | 0 | 0 | - | - | - | 0 |
Purchases of preferred stock and warrants | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | 1,161 | 1,161 | 2,302 | 3,469 | 2,308 | 2,308 | 3,347 | 2,180 | 17,080 | 36,576 | 34,396 | 34,396 | 19,496 | 0 | 0 | 0 | - | - | - | - |
Proceeds from sales of equity securities | ||||||||||||||||||||||||||||
23,038 | 23,456 | 589 | 589 | 635 | 217 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Acquisitions of businesses, net of cash received | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 123,928 | 114,940 | 102,166 | 92,224 | 67,577 | 67,112 | 4,907 | 4,907 | -517 | 0 | 0 | 0 |
Investments in affiliates | ||||||||||||||||||||||||||||
3,343 | 3,713 | 6,156 | 10,442 | 11,442 | 16,582 | 14,689 | 15,120 | 12,120 | 11,189 | 12,766 | 11,067 | 13,400 | 11,542 | 18,158 | 15,162 | 14,672 | 13,442 | 5,469 | 4,709 | 2,866 | 2,875 | 0 | 0 | 0 | - | - | - | 0 |
Return of investment in affiliate | ||||||||||||||||||||||||||||
- | - | - | - | - | 2,598 | 2,598 | 2,598 | 2,598 | 0 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Cash paid in asset acquisition | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 0 | 0 | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Purchases of property, plant and equipment | ||||||||||||||||||||||||||||
29,512 | 37,883 | 44,432 | 45,421 | 42,336 | 41,587 | 44,345 | 49,993 | 51,097 | 46,666 | 44,107 | 39,853 | 33,715 | 31,629 | 23,105 | 16,047 | 14,295 | 12,749 | 11,022 | 9,360 | 6,100 | 6,371 | 5,455 | 4,502 | 4,328 | 1,527 | 0 | 0 | 0 |
Proceeds from sale of assets | ||||||||||||||||||||||||||||
1,305 | 688 | 698 | 2,003 | 2,104 | 2,267 | 2,143 | 961 | 1,729 | 1,636 | 1,454 | 1,249 | 309 | 274 | 449 | 533 | 534 | 626 | 445 | 258 | 370 | 176 | 0 | 0 | 0 | - | - | - | - |
Proceeds from sale of discontinued operations, net of cash sold | ||||||||||||||||||||||||||||
0 | - | - | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Issuances of notes receivable | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1,000 | 0 | 0 | 0 |
Proceeds from repayment of notes receivable | ||||||||||||||||||||||||||||
0 | - | - | - | 0 | - | - | - | - | 1,500 | 1,500 | 1,500 | 1,500 | 0 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Proceeds from related party notes receivable | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 0 | 0 |
Net cash provided by (used in) investing activities | ||||||||||||||||||||||||||||
16,706 | 86,851 | 63,083 | -111,728 | -110,165 | -151,213 | -158,040 | 31,129 | 62,322 | 104,332 | 97,170 | 5,267 | 2,282 | -28,392 | -47,071 | -222,813 | -229,332 | -259,245 | -246,853 | -47,094 | -77,917 | -26,029 | -38,453 | -125,096 | -198,339 | -223,663 | 0 | 0 | 0 |
Cash flows from financing activities | ||||||||||||||||||||||||||||
Cash flows from financing activities | ||||||||||||||||||||||||||||
Proceeds from issuance of shares in a private placement | ||||||||||||||||||||||||||||
0 | - | - | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 25,000 | 0 | 0 | 0 | - | - | - | 0 |
Proceeds from issuance of shares and warrants in public offering, net of issuance costs | ||||||||||||||||||||||||||||
0 | 6,611 | 6,611 | 6,611 | 6,611 | 87,990 | 87,990 | 87,990 | 87,990 | 0 | 0 | 0 | 0 | - | - | - | - | 328,234 | 328,234 | 110,041 | 110,041 | 0 | 0 | 0 | 0 | - | - | - | - |
Acquisitions of noncontrolling interests | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | 913 | 913 | 913 | 913 | 0 | 0 | 0 | 0 | 1,566 | 1,566 | 1,566 | 1,566 | 0 | 0 | 0 | 0 | - | - | - | - |
Advances from lines of credit | ||||||||||||||||||||||||||||
19,067 | 11,757 | 5,953 | 5,533 | 4,730 | 4,561 | 4,574 | 4,860 | 5,467 | 5,906 | 7,330 | 6,859 | 5,941 | 5,075 | 3,821 | 5,092 | 10,485 | 15,232 | 17,717 | 16,356 | 10,235 | 4,676 | 0 | 0 | 0 | - | - | - | - |
Repayments of advances from lines of credit | ||||||||||||||||||||||||||||
18,139 | 10,301 | 5,584 | 5,720 | 4,774 | 4,328 | 4,608 | 4,571 | 5,556 | 6,493 | 7,645 | 7,035 | 6,067 | 4,816 | 3,747 | 5,504 | 10,570 | 16,944 | 17,798 | 19,574 | 13,705 | 6,494 | 0 | 0 | 0 | - | - | - | - |
Proceeds from issuance of subscriptions payable | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 |
Payments of capital lease obligations | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 0 | - | 0 | 0 | 0 |
Proceeds from long-term debt, net of issuance costs | ||||||||||||||||||||||||||||
0 | 376 | 26,235 | 220,235 | 220,235 | 219,859 | 194,040 | 40 | 199 | 325 | 285 | 832 | 673 | 547 | 547 | 37 | 37 | 81 | 81 | 44 | 164 | 268 | 407 | 590 | 641 | 493 | 0 | 0 | 0 |
Payments of long-term debt | ||||||||||||||||||||||||||||
572 | 618 | 602 | 663 | 661 | 623 | 619 | 548 | 536 | 519 | 738 | 768 | 1,164 | 1,201 | 1,380 | 1,571 | 1,383 | 1,564 | 1,555 | 1,357 | 1,020 | 679 | 0 | 0 | 0 | - | - | - | - |
Payments of deferred consideration for acquisitions | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | 8,678 | 8,678 | 8,696 | 8,696 | 6,705 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Proceeds from stock option and warrant exercises | ||||||||||||||||||||||||||||
6 | 313 | 1,575 | 1,710 | 2,319 | 2,336 | 1,187 | 1,235 | 1,129 | 980 | 1,852 | 2,172 | 9,563 | 19,165 | 20,434 | 21,751 | 21,672 | 14,462 | 12,423 | 10,895 | 3,726 | 1,489 | 1,633 | 1,381 | 737 | 414 | 0 | 0 | 0 |
Payment of stock issuance costs | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | 10 | 0 | 0 | 0 | 0 | - | - | - | - | 256 | 256 | 256 | 1,877 | 3,148 | 0 | 0 | 0 |
Net cash provided by financing activities | ||||||||||||||||||||||||||||
35,362 | 8,138 | 34,188 | 227,743 | 228,460 | 309,795 | 296,250 | 95,968 | 95,692 | 4,284 | -8,517 | -7,559 | -673 | 12,065 | 11,404 | 230,180 | 230,616 | 331,683 | 332,850 | 116,422 | 109,449 | 24,004 | 23,067 | 195,442 | 278,596 | 316,451 | 0 | 0 | 0 |
Effect of exchange rate changes on cash, cash equivalents, and restricted cash | ||||||||||||||||||||||||||||
-345 | -810 | -1,126 | -504 | -1,123 | 295 | 741 | 972 | 1,443 | 1,055 | 332 | -247 | -435 | -873 | -611 | -363 | 333 | 209 | 445 | 311 | -191 | -160 | -100 | -61 | -4 | 1 | 0 | 0 | 0 |
Net decrease in cash, cash equivalents, and restricted cash | ||||||||||||||||||||||||||||
-68,713 | -41,748 | -45,002 | -27,308 | -20,414 | 34,637 | 18,193 | 14,121 | 50,538 | 5,951 | 1,937 | -83,308 | -68,894 | -66,188 | -55,726 | 56,182 | 46,718 | 108,316 | 100,729 | 24,394 | -11,037 | -22,043 | -36,518 | 40,044 | 50,328 | 39,106 | 0 | 0 | 0 |
Supplemental Cash Flow Information [Abstract] | ||||||||||||||||||||||||||||
Cash paid during the period for interest | ||||||||||||||||||||||||||||
7,242 | 3,751 | 7,206 | 7,310 | 3,863 | 3,868 | 443 | 666 | 629 | 617 | 623 | 970 | 964 | 964 | 951 | 1,236 | 1,181 | 1,195 | 1,230 | 243 | 229 | 158 | 48 | 17 | 62 | 51 | 0 | 0 | 0 |
Cash paid during the period for income taxes | ||||||||||||||||||||||||||||
60 | 50 | 73 | 93 | 226 | 216 | 262 | 352 | 586 | 566 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Significant noncash activities | ||||||||||||||||||||||||||||
Accrued compensation paid in equity awards | ||||||||||||||||||||||||||||
0 | - | - | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Accretion of dividends on redeemable convertible preferred shares | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 18,391 | 0 | 0 | 0 |
Stock received as consideration for collaboration agreements | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | 18,766 | 23,248 | 22,815 | 18,482 | 9,149 | 13,688 | 9,021 | 9,021 | 14,246 | 9,681 | 20,796 | 22,128 | 19,303 | 0 | 0 | 0 |
Stock and warrants issued in business combinations | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 126,863 | 126,863 | 103,470 | 72,049 | 51,682 | 0 | 0 | 0 | - | - | - | - |
Stock issued to acquire noncontrolling interests | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | 5,082 | 5,082 | 5,082 | 5,082 | 0 | 0 | 0 | 0 | 9,412 | 9,412 | 9,412 | 9,412 | 0 | 0 | 0 | 0 | - | - | - | - |
Stock issued in asset acquisition | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | 4,401 | 4,401 | 4,401 | 4,401 | 0 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Contingent consideration assumed in asset acquisition | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | 3,660 | 3,660 | 3,660 | 3,660 | 0 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Noncash dividend to shareholders | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | 22,385 | 22,385 | 22,385 | 22,385 | 0 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Purchases of property and equipment included in accounts payable and other accrued liabilities | ||||||||||||||||||||||||||||
-1,468 | 694 | 871 | 1,226 | 2,782 | 2,267 | 2,208 | 746 | 3,141 | 2,257 | 1,863 | 3,096 | 945 | 652 | 1,175 | 836 | 1,621 | 782 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Cash, cash equivalents, and restricted cash | ||||||||||||||||||||||||||||
Purchases of equipment financed through debt | ||||||||||||||||||||||||||||
- | - | - | - | - | 234 | 193 | 76 | 76 | 0 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Proceeds from stock option exercises included in other receivables | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | - | - | - | 0 | - | - | - | - | - | - | - | - |
Stock issued and payable in Medistem, Inc. acquisition | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 |