| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 |
|---|---|---|---|---|---|---|---|---|---|
Cash flows from operating activities: | |||||||||
Net loss | |||||||||
-26,558 | -7,966 | -13,029 | -11,581 | -11,031 | -15,595 | -26,153 | - | - | - |
Net loss | |||||||||
- | - | - | - | - | - | - | -6,736 | -1,347 | -1,423 |
Adjustments to reconcile net loss to cash used in operating activities: | |||||||||
Impairment of intangible assets | |||||||||
1,142 | 0 | 0 | - | - | - | - | - | - | - |
Amortization and depreciation | |||||||||
1,186 | 1,199 | 848 | 744 | 676 | 462 | - | - | - | - |
Depreciation | |||||||||
- | - | - | - | - | - | 3 | - | - | - |
Amortization of patent costs | |||||||||
- | - | - | - | - | - | 141 | - | - | - |
Amortization of license fees | |||||||||
238 | 142 | 98 | 98 | 98 | 32 | 0 | - | - | - |
Lease expense | |||||||||
212 | 0 | 0 | - | - | - | - | - | - | - |
Increase in allowance for doubtful accounts | |||||||||
- | - | - | - | - | 0 | 0 | - | - | - |
Severance expense | |||||||||
880 | 0 | 0 | - | - | 624 | 0 | - | - | - |
Unrealized gain on investment | |||||||||
-2,419 | 284 | 342 | -202 | - | - | - | - | - | - |
Realized gain on the sale of investments | |||||||||
0 | 14,492 | 0 | 0 | - | - | - | - | - | - |
Unrealized loss on short-term investment securities | |||||||||
- | - | - | - | 0 | - | - | - | - | - |
Realized loss on short-term investment securities | |||||||||
220 | -54 | 0 | 0 | - | - | - | - | - | - |
Litigation expense | |||||||||
1,890 | 0 | 0 | - | - | - | - | - | - | - |
Gain on the sale of machinery and equipment | |||||||||
87 | 0 | 0 | - | -15 | 71 | 0 | - | - | - |
Interest due to debt conversion | |||||||||
- | - | - | - | - | - | 526 | 31 | 0 | - |
Warrant liability (gain) loss | |||||||||
0 | 48 | -157 | 29 | 144 | -3,676 | -23,602 | - | - | - |
(Gain) loss on investment | |||||||||
- | - | - | - | -95 | - | - | - | - | - |
Amortization and depreciation | |||||||||
- | - | - | - | - | - | - | 198 | 179 | 164 |
Amortization of debt issue costs | |||||||||
- | - | - | - | - | - | 4 | 18 | 1 | 35 |
Amortization of debt discount | |||||||||
- | - | - | - | - | - | 134 | 1,372 | 34 | 126 |
(Gain) loss on investment | |||||||||
- | - | - | - | - | -101 | 0 | - | - | - |
Accretion of interest on notes payable and accrued severance | |||||||||
47 | 10 | 29 | 37 | 45 | 0 | 0 | - | - | - |
Accretion of interest on Panacea investments | |||||||||
21 | 0 | 0 | - | - | - | - | - | - | - |
Warrant liability loss | |||||||||
- | - | - | - | - | - | - | -1,998 | 2,511 | - |
Warrant amendment inducement expense | |||||||||
- | - | - | - | - | 144 | 3,736 | 0 | - | - |
Equity-based compensation | |||||||||
3,539 | 3,187 | 941 | 880 | 1,326 | 2,293 | 980 | 807 | 376 | 144 |
Inventory write-off | |||||||||
985 | 0 | 0 | - | - | - | - | - | - | - |
Convertible note issued for outside services | |||||||||
- | - | - | - | - | - | - | - | 60 | - |
Equity-based payments for outside services | |||||||||
- | - | - | 30 | 2,259 | 2,231 | 1,381 | 416 | 0 | 2 |
Decrease in allowance for doubtful accounts | |||||||||
0 | 0 | -10 | 0 | 10 | - | - | - | - | - |
(Decrease) increase in inventory reserve | |||||||||
0 | 95 | 60 | -145 | -60 | 0 | 0 | - | - | - |
(Increase) decrease in assets: | |||||||||
Accounts receivable | |||||||||
-4 | -85 | 906 | -10 | 61 | 0 | 0 | - | - | - |
Grant receivable | |||||||||
- | - | - | - | - | - | - | - | -223 | 223 |
Inventory | |||||||||
207 | -333 | 129 | 531 | 701 | 620 | 175 | 552 | 369 | 253 |
Prepaid expenses and other assets | |||||||||
-280 | 181 | 551 | -497 | 478 | 214 | -10 | -7 | -194 | 211 |
Increase (decrease) in liabilities: | |||||||||
Operating lease obligations | |||||||||
-212 | 0 | 0 | - | - | - | - | - | - | - |
Operating lease obligations | |||||||||
-212 | 0 | 0 | - | - | - | - | - | - | - |
Deposits | |||||||||
- | - | - | - | - | - | - | - | -1 | - |
Accounts payable | |||||||||
-732 | 323 | 473 | -136 | 86 | 625 | -629 | 705 | -222 | 190 |
Accrued interest payable to related parties | |||||||||
- | - | - | - | - | - | - | -2 | -162 | - |
Accrued interest payable to shareholders | |||||||||
- | - | - | - | - | - | - | - | - | 112 |
Accrued expenses | |||||||||
792 | -166 | 586 | -21 | 649 | -93 | 114 | -58 | 317 | 191 |
Accrued severance | |||||||||
-88 | 0 | -203 | -233 | -225 | 0 | 0 | - | - | - |
Deferred revenue | |||||||||
-78 | 54 | 28 | - | 0 | -179 | 179 | 0 | -223 | 223 |
Net cash used in operating activities | |||||||||
- | - | - | - | - | -6,582 | 3,855 | - | - | - |
Net cash used in operating activities | |||||||||
-14,587 | -17,844 | -12,068 | -9,887 | -7,321 | - | - | -1,764 | -3,449 | -909 |
Cash flows from investing activities: | |||||||||
Acquisition of patents and trademarks | |||||||||
515 | 656 | 450 | 356 | 413 | 726 | 290 | 162 | 598 | 108 |
Purchase of machinery and equipment held for resale | |||||||||
- | - | - | - | - | - | - | 0 | - | - |
Acquisition of machinery and equipment | |||||||||
527 | 448 | 1,156 | 197 | 37 | 212 | 2,994 | 0 | - | - |
Acquisition of license | |||||||||
50 | 0 | 0 | - | - | - | - | - | - | - |
Proceeds from the sale of machinery and equipment | |||||||||
-166 | 0 | 0 | - | - | - | - | - | - | - |
Investment in Panacea | |||||||||
12,000 | 0 | 0 | - | - | - | - | - | - | - |
Proceeds from the sale of investments | |||||||||
0 | 13,051 | 0 | 0 | - | - | - | - | - | - |
Sales and maturities of short-term investment securities | |||||||||
-1,841 | 37,415 | 0 | - | - | - | - | - | - | - |
Purchase of short-term investment securities | |||||||||
-19,320 | 34,215 | 58,979 | - | - | - | - | - | - | - |
Sales and maturities of short-term investment securities | |||||||||
- | - | - | 0 | - | - | - | - | - | - |
Purchase of short-term investment securities | |||||||||
- | - | - | 0 | 0 | - | - | - | - | - |
Purchase of machinery and equipment held for resale | |||||||||
- | - | - | - | - | - | 457 | - | - | - |
Payment of license fees | |||||||||
- | - | - | - | - | 1,450 | 0 | - | - | - |
Acquisition of NASCO Products, LLC | |||||||||
- | - | - | - | - | 250 | 0 | - | - | - |
Proceeds from the sale of machinery and equipment | |||||||||
- | - | - | - | - | 631 | 0 | - | - | - |
Equity investment | |||||||||
- | - | - | - | - | 700 | 0 | - | - | - |
Net cash used in investing activities | |||||||||
- | - | - | - | - | -2,707 | -3,742 | - | - | - |
Acquisition of office furniture and fixtures | |||||||||
- | - | - | - | - | - | - | - | 9 | - |
Net cash provided by investing activities | |||||||||
4,551 | 15,145 | -60,586 | -553 | -450 | - | - | -162 | -607 | -108 |
Cash flows from financing activities: | |||||||||
Net proceeds from June 2015 registered direct offering | |||||||||
- | - | - | - | 5,576 | 0 | - | - | - | - |
Payment on note payable | |||||||||
700 | 800 | 333 | 333 | - | - | 1,620 | 41 | 443 | - |
Proceeds from exercise of stock options | |||||||||
0 | 444 | 0 | 0 | - | 48 | 5 | 0 | - | - |
Net proceeds from exercise of stock warrants | |||||||||
10,615 | 0 | 12,447 | 0 | 50 | 486 | 2,254 | - | - | - |
Net proceeds from exercise of warrants | |||||||||
- | - | - | - | - | - | - | 0 | - | - |
Net proceeds from warrant exchange program | |||||||||
- | - | - | - | - | - | 3,239 | 0 | - | - |
Proceeds from issuance of notes | |||||||||
- | - | - | - | - | - | 150 | 56 | 215 | - |
Payments on borrowings - demand bank loan | |||||||||
- | - | - | - | 174 | 0 | 0 | - | - | - |
Payments on borrowings - note payable | |||||||||
- | - | - | - | -333 | 0 | - | - | - | - |
Net proceeds from October 2017 registered direct offering | |||||||||
0 | 0 | 50,732 | 0 | 0 | 9,324 | - | - | - | - |
Net proceeds from October 2016 registered direct offering | |||||||||
- | - | - | 10,707 | 0 | 0 | - | - | - | - |
Net proceeds from July 2016 registered direct offering | |||||||||
- | - | - | 4,682 | 0 | 0 | - | - | - | - |
Net proceeds from February 2016 registered direct offering | |||||||||
- | - | - | 5,091 | 0 | 0 | - | - | - | - |
Payments on borrowings - convertible notes | |||||||||
- | - | - | - | - | - | 339 | 0 | - | - |
Payment of deferred private placement costs | |||||||||
- | - | - | - | - | - | - | - | - | 60 |
Payment on demand loan | |||||||||
- | - | - | - | - | - | - | - | - | 71 |
Proceeds from issuance of notes and warrants to shareholders | |||||||||
- | - | - | - | - | - | - | - | - | 723 |
Proceeds from issuance of convertible notes | |||||||||
- | - | - | - | - | - | - | 210 | 1,300 | - |
Proceeds from issuance of common stock | |||||||||
- | - | - | - | - | - | - | - | - | 549 |
Net proceeds from registered direct offering | |||||||||
- | - | - | - | - | - | 0 | 0 | - | - |
Net proceeds from private placement | |||||||||
- | - | - | - | - | - | - | 1,467 | - | - |
Stock cancellation | |||||||||
- | - | - | - | 34 | 0 | 0 | - | - | - |
Other capital contribution | |||||||||
- | - | - | - | - | - | 1 | 0 | - | - |
Net payments from related party | |||||||||
- | - | - | - | 46 | -4 | 5 | - | - | -120 |
Payment of debt issuance costs | |||||||||
- | - | - | - | - | - | - | - | 23 | - |
Net payments to related party | |||||||||
- | - | - | - | - | - | - | 21 | 22 | 4 |
Net advances from officers | |||||||||
- | - | - | - | - | 7 | -3 | 4 | -10 | 2 |
Net cash provided by financing activities | |||||||||
- | - | - | - | - | 9,862 | 5,717 | - | - | - |
Net cash used in financing activities | |||||||||
9,915 | -355 | 62,845 | 20,149 | 5,130 | - | - | 1,675 | 4,308 | 1,018 |
Net increase (decrease) in cash and cash equivalents | |||||||||
-119 | -3,054 | -9,808 | - | - | - | - | - | - | - |
Net (decrease) increase in cash and cash equivalents | |||||||||
- | - | - | 9,707 | -2,642 | 572 | 5,830 | -252 | 251 | - |
Net (decrease) increase in cash | |||||||||
- | - | - | - | - | - | - | - | - | 0 |
Supplemental disclosures of cash flow information: | |||||||||
Net cash paid for: | |||||||||
Cash paid during the period for interest | |||||||||
3 | 0 | 29 | 37 | 7 | 7 | 135 | 15 | 196 | 16 |
Cash paid during the period for income taxes | |||||||||
0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
Non-cash transactions: | |||||||||
Reclassification of derivative liability to equity due to warrant amendments | |||||||||
- | - | - | - | - | 7,367 | 14,433 | - | - | - |
Patent and trademark additions included in accounts payable | |||||||||
155 | 152 | 188 | 185 | 310 | 193 | 42 | 0 | - | 39 |
Patent and trademark additions included in accrued expenses | |||||||||
- | - | - | - | 17 | 0 | 0 | - | - | - |
Machinery and equipment additions included in accounts payable | |||||||||
0 | 18 | 77 | 7 | 2 | 10 | 0 | - | - | - |
Unrealized (gain) loss on short-term investment securities | |||||||||
-206 | 27 | 0 | - | - | - | - | - | - | - |
Unrealized gain on short-term investment securities | |||||||||
- | - | - | 0 | - | - | - | - | - | - |
Licenses acquired with notes payable | |||||||||
0 | 2,326 | 0 | 0 | - | - | - | - | - | - |
Issuance of common stock for the acquisition of NASCO Products, LLC | |||||||||
- | - | - | - | - | 1,952 | 0 | - | - | - |
Issuance of warrants as a derivative liability issued under a consulting agreement and included in prepaid consulting fees | |||||||||
- | - | - | - | - | 2,810 | 0 | - | - | - |
Warrants issued under a consulting agreement resulting in an increase in capital and included in prepaid consulting fees | |||||||||
- | - | - | - | - | 1,260 | 0 | - | - | - |
Patent additions acquired with note payable | |||||||||
- | - | - | - | - | 925 | 0 | - | - | - |
Issuance of common stock in satisfaction of accrued expense | |||||||||
- | - | - | - | - | - | 0 | - | - | - |
Reclassification of warrant liability to capital in excess of par | |||||||||
0 | 167 | 0 | 2,810 | 0 | 0 | - | - | - | - |
Stock issued in connection with equity investment | |||||||||
1,297 | 0 | 0 | - | - | - | - | - | - | - |
Reclassification of machinery and equipment purchases to inventory | |||||||||
- | - | - | - | - | 37 | 0 | - | - | - |
Issuance of common stock in connection with equity investment | |||||||||
- | - | - | - | 325 | 394 | - | -30 | 0 | - |
Other capital contribution | |||||||||
- | - | - | - | - | 25 | 0 | - | - | - |
License fee included in accrued expenses | |||||||||
- | - | - | - | - | 300 | 0 | - | - | - |
Equity investment included in accrued expenses | |||||||||
- | - | - | - | - | 325 | 0 | - | - | - |
Common stock issued in connection with litigation expense | |||||||||
- | - | - | - | - | 394 | 0 | - | - | - |
Common stock issued as payment of accounts payable | |||||||||
- | - | - | - | - | - | - | -359 | 0 | - |
Payment of accounts payable for patent costs | |||||||||
- | - | - | - | - | - | - | - | 500 | - |
Payment of accounts payable for deferred private placement costs | |||||||||
- | - | - | - | - | - | - | - | 526 | - |
Accounts payable converted to promissory notes | |||||||||
- | - | - | - | - | - | 769 | 0 | 587 | - |
Supplemental accounts payable | |||||||||
- | - | - | - | - | - | - | 359 | 1,613 | - |
Accrued interest converted to promissory notes | |||||||||
- | - | - | - | - | - | 26 | 0 | - | - |
Non controlling interest acquired for common stock | |||||||||
- | - | - | - | - | - | - | - | 0 | - |
Deferred private placement costs charged to contributed capital | |||||||||
- | - | - | - | - | - | - | 4 | 587 | - |
Notes payable and accrued interest converted to common shares | |||||||||
- | - | - | - | - | - | 1,650 | 120 | - | - |
Notes payable converted to common shares | |||||||||
- | - | - | - | - | - | - | - | 0 | 31 |
Conversion of shareholder note and accrued interest to common shares and warrants | |||||||||
- | - | - | - | - | - | - | - | 614 | - |
Original issue discount on convertible debt | |||||||||
- | - | - | - | - | - | - | 12 | 251 | - |
Conversion of notes payable to convertible notes | |||||||||
- | - | - | - | - | - | - | - | 315 | - |
Beneficial conversion value upon issuance of convertible debt recorded as debt discount and an increase in capital in excess of par value | |||||||||
- | - | - | - | - | - | - | 116 | 1,062 | - |
Common stock issued for fees relating to January 2013 preferred stock private placement | |||||||||
- | - | - | - | - | - | - | 0 | - | - |
Common stock issued for fees relating to December 2013 warrant exchange program | |||||||||
- | - | - | - | - | - | - | 0 | - | - |
Common stock issued in payment of preferred stock dividend payable | |||||||||
- | - | - | - | - | - | 93 | 0 | - | - |
Common stock issued for fees relating to January 2013 preferred stock private placement | |||||||||
- | - | - | - | - | - | 416 | - | - | - |
Refinance of convertible note to note payable | |||||||||
- | - | - | - | - | - | 57 | 0 | - | - |
Issuance of warrants as derivative liability instruments upon conversion of notes payable and accrued interest | |||||||||
- | - | - | - | - | - | - | - | 0 | - |
Issuance of warrants as derivative liability instruments and reduction of capital | |||||||||
- | - | - | - | - | - | 5,675 | 1,532 | - | - |
Increase in warrant liability and reduction in capital as a result of lowering the exercise price on certain warrants | |||||||||
- | - | - | - | - | - | 626 | - | - | - |
Increase in warrant liability and reduction in capital as a result of lowering the exercise price on certain warrants | |||||||||
- | - | - | - | - | - | - | 0 | - | - |
Issuance of warrants as derivative liability instruments | |||||||||
- | - | - | - | - | - | - | 92 | - | - |
Reclassification of derivative liability to equity due to warrant exercise | |||||||||
- | - | - | - | - | - | - | 0 | - | - |
Reclassification of derivative liability to equity due to warrant exchange program | |||||||||
- | - | - | - | - | - | 19,639 | 0 | - | - |
Common stock issued for fees relating to December 2013 warrant exchange program | |||||||||
- | - | - | - | - | - | 462 | - | - | - |
Deferred debt issuance costs included in accounts payable | |||||||||
- | - | - | - | - | - | - | - | - | 526 |
Issuance of warrants as derivative liability instruments and reduction of capital | |||||||||
- | - | - | - | - | - | - | - | 3,061 | - |
Derivative warrant liability recorded as original issuance discount to debt | |||||||||
- | - | - | - | - | - | - | - | 0 | - |