| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | |
|---|---|---|---|---|---|---|
Cash flows from operating activities: | ||||||
Net loss | ||||||
-45,406 | -61,368 | -52,028 | -57,878 | - | - | |
Adjustments to reconcile net loss to net cash used in operating activities | ||||||
Net loss | ||||||
- | - | - | - | -74,286 | -36,478 | |
Stock-based compensation expense | ||||||
5,497 | 9,627 | 8,301 | 10,113 | 8,582 | 1,553 | |
Non-cash interest expense | ||||||
- | - | 13 | 43 | 62 | - | |
Non-cash interest expense | ||||||
- | - | - | - | - | 46 | |
Depreciation expense | ||||||
263 | 261 | 188 | 212 | 70 | 16 | |
Impairment of assets | ||||||
80 | - | - | - | - | - | |
Loss on disposal of fixed assets | ||||||
-20 | - | - | -328 | - | - | |
Common stock issued in lieu of milestone payment | ||||||
- | - | - | - | - | 3,569 | |
Unrealized foreign currency transaction losses (gains) | ||||||
-5 | -76 | 46 | -6 | -82 | -93 | |
Premium on marketable securities, net | ||||||
69 | 6 | 359 | 340 | 2,036 | 225 | |
Amortization of discount on marketable debt securities | ||||||
788 | 670 | -246 | -1,037 | - | - | |
Amortization of premium on marketable securities | ||||||
- | - | - | - | 1,243 | 31 | |
Changes in operating assets and liabilities: | ||||||
Prepaid expenses and other current assets | ||||||
-729 | -199 | 569 | -413 | 363 | 1,121 | |
Tax incentive receivable | ||||||
-1,288 | 666 | 553 | -970 | 1,014 | -1,133 | |
Accounts payable | ||||||
-2,958 | 432 | 448 | -4,625 | 4,914 | 815 | |
Accrued restructuring costs | ||||||
2,709 | - | - | - | - | - | |
Accrued expenses and other | ||||||
-2,190 | 628 | 575 | - | - | - | |
Other assets | ||||||
-37 | - | - | - | - | - | |
Accrued expenses | ||||||
- | - | - | -2,254 | 3,192 | 2,327 | |
Net cash used in operating activities | ||||||
-40,783 | -51,487 | -43,784 | -51,975 | - | - | |
Net cash used in operating activities | ||||||
- | - | - | - | -59,554 | -28,241 | |
Cash flows from investing activities: | ||||||
Proceeds from sales and maturities of marketable debt securities | ||||||
109,471 | 110,388 | 150,213 | 188,600 | 195,987 | - | |
Purchases of marketable debt securities | ||||||
82,861 | 117,147 | 114,511 | 136,528 | 287,491 | 57,200 | |
Purchases of property and equipment | ||||||
764 | 108 | 55 | 660 | 595 | 58 | |
Proceeds from sales of property and equipment | ||||||
3 | - | - | - | - | - | |
Payments for leasehold improvements on right-of-use assets | ||||||
586 | - | - | - | - | - | |
Deposits for leased property | ||||||
- | - | - | -35 | 19 | 57 | |
Net cash provided by investing activities | ||||||
25,263 | -6,867 | 35,647 | 51,447 | - | - | |
Net cash provided by investing activities | ||||||
- | - | - | - | -92,118 | -57,315 | |
Cash flows from financing activities: | ||||||
Proceeds from issuance of redeemable convertible preferred stock, net of issuance costs | ||||||
- | - | - | - | - | 442 | |
Proceeds from issuance of notes payable | ||||||
- | - | 20,000 | - | - | 7,386 | |
Payments of debt offering costs | ||||||
- | - | - | - | - | 49 | |
Repayment of notes payable | ||||||
5,455 | - | 3,633 | 2,935 | 1,381 | - | |
Proceeds from exercise of common stock options and employee stock purchase plan | ||||||
194 | 2,360 | 195 | 220 | 974 | 3 | |
Proceeds from public offerings, net of commissions and underwriting discounts | ||||||
- | 64,860 | - | - | 130,044 | 102,672 | |
Payments of public offering costs | ||||||
- | 312 | - | - | 473 | 2,312 | |
Net cash (used in) provided by financing activities | ||||||
-5,261 | 66,908 | 16,562 | -2,715 | - | - | |
Net increase (decrease) in cash, cash equivalents and restricted cash | ||||||
-20,781 | 8,554 | 8,425 | - | - | - | |
Net cash provided by (used in) financing activities | ||||||
- | - | - | - | 129,164 | 108,142 | |
Net increase (decrease) in cash and cash equivalents | ||||||
- | - | - | -3,243 | -22,508 | 22,586 | |
Supplemental disclosure of non-cash investing and financing activities: | ||||||
Public offering costs included in accounts payable | ||||||
- | 138 | - | - | - | - | |
Right-of-use asset obtained in exchange for operating lease obligation | ||||||
6,817 | - | - | - | - | - | |
Accretion of redeemable convertible preferred stock to redemption values | ||||||
- | - | - | - | - | 92 | |
Deferred offering costs included in accounts payable and accrued expenses | ||||||
- | - | - | - | - | 148 | |
Property and equipment included in accounts payable | ||||||
- | - | - | - | 298 | - | |
Conversion of redeemable preferred stock to common stock | ||||||
- | - | - | - | - | 104,331 | |
Conversion of milestone liabilities to common stock | ||||||
- | - | - | - | - | 3,569 | |
Supplemental disclosure of cash flow information: | ||||||
Cash paid for interest | ||||||
1,217 | 1,144 | 141 | 388 | - | - | |
Cash paid for interest | ||||||
- | - | - | - | 584 | 632 | |