| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Revenues [Abstract] | ||||||||||
Collaboration revenue | ||||||||||
3,600 | 0 | 0 | 28,525 | 24,369 | 15,392 | 0 | 8,462 | 7,165 | 4,373 | 0 |
Contract manufacturing revenue | ||||||||||
0 | 0 | 9,821 | - | - | - | - | 0 | - | - | - |
Net product revenue | ||||||||||
- | - | - | - | - | 9,840 | 31,699 | 35,826 | 30,411 | 19,069 | 0 |
Total revenue | ||||||||||
3,648 | 0 | 9,821 | 28,850 | 27,182 | 28,947 | 33,012 | 44,326 | 37,576 | 23,442 | 0 |
Operating expenses: | ||||||||||
Cost of contract manufacturing | ||||||||||
0 | 0 | 10,729 | 22,173 | 22,356 | 14,342 | 0 | 0 | - | - | - |
Research and development | ||||||||||
115,639 | 100,925 | 67,449 | 41,840 | 27,860 | 11,893 | 8,372 | 21,414 | 33,043 | 28,643 | 21,438 |
Cost of contract manufacturing | ||||||||||
- | - | - | - | - | 5,263 | 21,241 | 19,496 | 19,293 | 12,846 | 0 |
Royalty expense | ||||||||||
- | - | - | 295 | 345 | 591 | 1,242 | 1,353 | 1,205 | 843 | 0 |
Selling, general and administrative | ||||||||||
60,792 | 38,950 | 25,885 | 26,996 | 26,347 | 34,639 | 46,218 | 49,494 | 60,459 | 51,270 | 14,102 |
Acquired in-process research and development expense | ||||||||||
251,438 | 0 | 0 | - | - | - | - | - | - | - | - |
Loss on contract termination | ||||||||||
0 | 0 | 478 | 0 | 0 | - | - | - | - | - | - |
Change in fair value of contingent consideration | ||||||||||
5,600 | 1,300 | 24,100 | 1,800 | -2,000 | 0 | 0 | - | - | - | - |
Asset impairment charges | ||||||||||
0 | 0 | 1,116 | 8,431 | 0 | 838 | - | - | - | - | - |
Total operating expenses | ||||||||||
433,469 | 141,175 | 129,757 | 101,535 | 74,908 | -12,414 | 77,949 | 91,757 | 114,000 | 93,602 | 35,540 |
Restructuring | ||||||||||
- | - | - | - | - | - | 876 | 0 | 0 | - | - |
Impairment of long-lived assets | ||||||||||
- | - | - | - | - | - | 0 | 0 | - | - | - |
Net gain on sale of business | ||||||||||
- | - | - | - | - | 79,980 | 0 | 0 | - | - | - |
Loss from operations | ||||||||||
-429,821 | -141,175 | -119,936 | -72,685 | -47,726 | 41,361 | -44,937 | -47,431 | -76,424 | -70,160 | -35,540 |
Other income (expense): | ||||||||||
Interest income | ||||||||||
9,804 | 7,170 | 1,090 | 443 | 101 | 20 | - | 53 | 37 | 5 | 10 |
Interest expense | ||||||||||
-2 | -6 | -2,644 | -2,825 | -3,060 | -3,090 | -6,592 | 10,313 | 7,644 | 10,013 | 9,188 |
Loss on sale of marketable securities | ||||||||||
- | - | - | - | 5,746 | 0 | 0 | - | - | - | - |
Loss on extinguishment of debt | ||||||||||
0 | 0 | -4,876 | 0 | 0 | -1,254 | 0 | 0 | - | - | - |
Change in fair value of common stock warrant liabilities | ||||||||||
- | - | - | - | - | -14 | 759 | -147 | -240 | 0 | 0 |
Change in fair value of common stock warrant liabilities | ||||||||||
-145 | -169 | -297 | -5,387 | 1,103 | -25,332 | 21,927 | -11,811 | -445 | -6,725 | 755 |
Other income (expense), net | ||||||||||
371 | 10,126 | 47 | 46 | -71 | -784 | 96 | -1,354 | -86 | -111 | -416 |
Total other income | ||||||||||
10,318 | 17,459 | -6,086 | 3,051 | -9,879 | 20,210 | -27,664 | 50 | -7,488 | -3,394 | -10,349 |
Loss from continuing operations before income taxes | ||||||||||
- | - | - | -69,634 | -57,605 | 61,571 | -72,601 | -47,381 | -83,912 | -73,554 | -45,889 |
Income tax benefit | ||||||||||
- | - | - | -900 | -15,901 | 84 | 0 | 5 | -9 | 10 | 0 |
Loss from continuing operations | ||||||||||
-419,503 | -123,716 | -126,022 | -68,686 | -41,704 | 61,487 | -72,601 | - | - | - | - |
Loss from discontinued operations | ||||||||||
0 | -198 | -795 | -1,021 | 67,848 | -52,900 | -8,255 | - | - | - | - |
Net loss | ||||||||||
-419,503 | -123,914 | -126,817 | -69,707 | 26,144 | 8,587 | -80,856 | -47,386 | -83,903 | -73,564 | -45,889 |
Net loss per share, basic and diluted: | ||||||||||
Net loss per share, basic and diluted | ||||||||||
Continuing operations (in usd per share) | ||||||||||
-9.74 | -3.27 | -4.62 | -2.77 | - | - | - | - | - | - | - |
Discontinued operations (in usd per share) | ||||||||||
0.00 | 0.00 | -0.03 | -0.04 | - | - | - | - | - | - | - |
Net loss per share, basic and diluted (in dollars per share) | ||||||||||
-9.74 | -3.27 | -4.65 | -2.81 | - | - | - | -0.59 | -1.96 | -17.63 | -40.97 |
Net (loss) income per share, basic - continuing operations (in dollars per share) | ||||||||||
- | - | - | - | -1.94 | 3.45 | -5.35 | - | - | - | - |
Net (loss) income per share, basic - discontinued operations (in dollars per share) | ||||||||||
- | - | - | - | 3.16 | -2.97 | -0.61 | - | - | - | - |
Net (loss) income per share, basic (in dollars per share) | ||||||||||
- | - | - | - | 1.22 | 0.48 | -5.96 | - | - | - | - |
Net (loss) income per share, diluted: | ||||||||||
Net (loss) income per share, diluted - continuing operations (in dollars per share) | ||||||||||
- | - | - | - | -1.94 | 3.44 | -5.35 | - | - | - | - |
Net (loss) income per share, diluted - discontinued operations (in dollars per share) | ||||||||||
- | - | - | - | 3.16 | -2.96 | -0.61 | - | - | - | - |
Net (loss) income per share, diluted (in dollars per share) | ||||||||||
- | - | - | - | 1.22 | 0.48 | -5.96 | - | - | - | - |
Weighted average common shares outstanding, basic and diluted | ||||||||||
Weighted average number of shares used in the calculation of basic and diluted net loss per common share (shares) | ||||||||||
43,078 | 37,884 | 27,301 | 24,785 | - | - | - | - | 42,712 | 4,173 | 1,120 |
Weighted average shares outstanding, basic (in shares) | ||||||||||
- | - | - | - | 21,449 | 17,825 | 13,571 | 80,558 | - | - | - |
Weighted average shares outstanding, diluted (in shares) | ||||||||||
- | - | - | - | 21,449 | 17,855 | 13,571 | 80,558 | - | - | - |
Statements of Comprehensive Income (Loss) | ||||||||||
Net income | ||||||||||
-419,503 | -123,914 | -126,817 | -69,707 | 26,144 | - | - | -47,386 | -83,903 | -73,564 | -45,889 |
Comprehensive loss | ||||||||||
- | - | - | - | - | - | - | -47,386 | -83,903 | -73,564 | - |
Service and other product revenue | ||||||||||
Total revenue | ||||||||||
- | - | - | 325 | 2,813 | 3,715 | 1,313 | 38 | 0 | - | - |