| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Collaboration revenue | ||||||||||
- | 146 | 6,389 | 6,861 | 4,332 | 1,373 | 800 | 800 | 667 | 0 | - |
Operating expenses: | ||||||||||
Research and development | ||||||||||
38,331 | 34,134 | 45,084 | 157,791 | 106,785 | 32,706 | 42,852 | 83,446 | 57,083 | 12,910 | 4,556 |
General and administrative | ||||||||||
19,527 | 19,918 | 14,798 | 14,377 | 17,647 | 12,166 | 15,661 | 19,523 | 14,984 | 11,636 | 7,567 |
Total operating expenses | ||||||||||
57,858 | 54,052 | 59,882 | 172,168 | 124,432 | 44,872 | 58,513 | 102,969 | 72,067 | 24,546 | 12,123 |
Loss from operations | ||||||||||
-57,858 | -53,906 | -53,493 | -165,307 | -120,100 | -43,499 | -57,713 | -102,169 | -71,400 | -24,546 | -12,123 |
Other income, net | ||||||||||
813 | 631 | 465 | 134 | 12 | -5 | -579 | -13 | 39 | 765 | 13 |
Non-cash inducement warrant expense | ||||||||||
60,751 | - | - | - | - | - | - | - | - | - | - |
Change in fair value of warrants | ||||||||||
- | - | - | - | - | 11,723 | 1,185 | 6,050 | 7,583 | -8,889 | 4,461 |
Change in fair value of derivative liabilities | ||||||||||
0 | 158 | -1,295 | -124 | - | - | - | - | - | - | - |
Net loss | ||||||||||
-117,796 | -53,117 | -54,323 | -165,297 | -120,088 | -31,781 | -57,107 | -96,132 | -63,778 | -32,670 | -7,649 |
Preferred stock dividends | ||||||||||
- | 16,998 | 18,938 | 7,123 | - | - | - | - | - | - | - |
Settlement of a related party relationship | ||||||||||
- | 207,361 | - | - | - | - | - | - | - | - | - |
Net income (loss) applicable to common stockholders | ||||||||||
-117,796 | 137,246 | -73,261 | -172,420 | -120,088 | -31,781 | - | - | - | - | - |
Basic and diluted net loss per share | ||||||||||
- | - | - | - | -0.96 | -0.31 | -0.66 | -1.22 | -0.97 | -0.71 | -0.33 |
Net income (loss) per share - basic | ||||||||||
-0.70 | 0.96 | -0.53 | -1.32 | - | - | - | - | - | - | - |
Net income (loss) per share - diluted | ||||||||||
-0.70 | 0.96 | -0.53 | -1.32 | - | - | - | - | - | - | - |
Weighted average common shares outstanding used to compute basic and diluted net loss per share | ||||||||||
- | - | - | - | 125,416 | 101,130 | 85,943 | 78,546 | 66,003 | 46,003 | 23,108 |
Weighted average common shares outstanding used to compute basic net income (loss) per share | ||||||||||
167,952 | 143,508 | 136,938 | 130,391 | - | - | - | - | - | - | - |
Weighted average common shares outstanding used to compute diluted net income (loss) per share | ||||||||||
167,952 | 143,710 | 136,938 | 130,391 | - | - | - | - | - | - | - |