| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | |
|---|---|---|---|---|---|---|
Cash flows from operating activities: | ||||||
Net loss | ||||||
-37,589 | -35,358 | -29,105 | -29,832 | -28,427 | -14,241 | |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||
Depreciation and amortization | ||||||
- | - | - | 2,543 | 2,452 | - | |
Stock-based compensation | ||||||
1,612 | 1,178 | 692 | 1,168 | - | - | |
Change in operating lease right-of-use assets | ||||||
-841 | - | - | - | - | - | |
Depreciation and amortization | ||||||
683 | 764 | 2,553 | - | - | 3,042 | |
Effective interest on financing obligations | ||||||
860 | 304 | 51 | - | - | - | |
Capitalized effective interest | ||||||
582 | 294 | 0 | - | - | - | |
Accretion of interest on marketable securities | ||||||
55 | 131 | -2 | -259 | -313 | - | |
Cost of debt subordination | ||||||
- | - | - | - | - | 141 | |
Revaluation of warrants to fair value | ||||||
- | - | - | - | -48 | 185 | |
Accretion of interest | ||||||
- | - | - | - | - | 1,544 | |
Impairment of long-lived assets | ||||||
- | - | - | - | 145 | 166 | |
Deferred rent | ||||||
0 | -936 | -443 | -6 | 52 | 265 | |
Impairment loss | ||||||
0 | 511 | 70 | - | - | - | |
Stock-based compensation | ||||||
- | - | - | - | 653 | 184 | |
Gain on debt forgiveness | ||||||
- | - | - | - | - | 497 | |
Loss on debt extinguishment | ||||||
- | - | - | - | -446 | 0 | |
Gain on sale of equipment | ||||||
- | - | - | 51 | 0 | - | |
Loss on sale of Zosano Inc. | ||||||
- | - | - | -57 | 0 | - | |
Other | ||||||
-93 | 14 | 8 | 31 | 17 | -61 | |
Change in operating assets and liabilities | ||||||
Accounts receivable from joint venture partner | ||||||
- | - | - | - | - | -3,426 | |
Prepaid expenses and other assets | ||||||
193 | -1,208 | 1,279 | 36 | 222 | -154 | |
Accounts payable | ||||||
1,764 | 98 | -34 | 172 | 724 | -2,631 | |
Accounts receivable | ||||||
- | - | - | - | -111 | 111 | |
Accrued compensation and other accrued liabilities | ||||||
1,288 | -1,676 | 224 | -101 | 101 | 0 | |
Accrued compensation and other accrued liabilities | ||||||
- | - | - | 72 | 38 | -1,118 | |
Operating lease liabilities | ||||||
-963 | - | - | - | - | - | |
Deferred revenue | ||||||
- | - | - | - | -170 | -955 | |
Net cash used in operating activities | ||||||
-34,817 | -29,122 | - | - | - | - | |
Net cash used in operating activities | ||||||
- | - | -26,839 | -25,686 | -24,155 | -10,915 | |
Cash flows from investing activities | ||||||
Proceeds from maturities of marketable securities | ||||||
17,400 | 16,050 | - | - | - | - | |
Decrease in restricted cash | ||||||
- | - | - | - | - | -30 | |
Purchases of marketable securities | ||||||
3,476 | 29,788 | 8,280 | 0 | 42,606 | 0 | |
Proceeds from maturities of marketable securities | ||||||
- | - | 8,274 | 30,208 | 12,120 | 0 | |
Purchases of property and equipment | ||||||
11,760 | 5,490 | 1,244 | - | 432 | 1,176 | |
Proceeds from the sale of Zosano Inc. | ||||||
- | - | - | 225 | - | - | |
Proceeds from sale of Zosano Inc. | ||||||
- | - | - | - | 0 | - | |
Increase in other investment | ||||||
- | - | - | -63 | 28 | -13 | |
Net cash provided by (used in) investing activities | ||||||
- | - | -1,228 | 30,272 | -30,946 | -1,133 | |
Proceeds from sale of property and equipment | ||||||
0 | 15 | 22 | 63 | 0 | - | |
Net cash (used in) provided by investing activities | ||||||
2,164 | -19,213 | - | - | - | - | |
Cash flows from financing activities: | ||||||
Proceeds from offering of securities, net of costs | ||||||
- | - | 26,623 | 0 | - | - | |
Proceeds from issuance of securities | ||||||
- | - | - | - | - | 0 | |
Proceeds from build-to-suit obligation, net of issuance costs | ||||||
6,126 | 7,570 | 0 | - | - | - | |
Principal payments on financing obligations | ||||||
3,079 | 6,999 | 5,808 | 2,876 | 11,465 | 0 | |
Payment of term loan end of term charge | ||||||
0 | 351 | 0 | - | - | - | |
Proceeds from exercise of warrants and issuance of common stock | ||||||
- | - | 4,041 | 0 | - | - | |
Proceeds from exercise of stock options and issuance of common stock | ||||||
- | - | 139 | 5 | 37 | 38 | |
Proceeds from borrowing under related parties bridge notes | ||||||
- | - | - | - | - | 3,833 | |
Proceeds from debt financing, net of issuance costs | ||||||
- | - | - | - | 11,705 | 3,920 | |
Proceeds from initial public offering of securities, net of underwriting commissions and discounts | ||||||
- | - | - | - | 47,140 | 0 | |
Payment of deferred offering costs | ||||||
- | - | - | - | 1,359 | 442 | |
Net cash provided by financing activities | ||||||
- | - | 24,995 | 3,771 | 60,533 | 7,349 | |
Net cash provided by (used in) financing activities | ||||||
29,829 | 45,824 | - | - | - | - | |
Net increase (decrease) in cash, cash equivalents and restricted cash | ||||||
-2,824 | -2,511 | -3,072 | - | - | - | |
Net (decrease) increase in cash and cash equivalents | ||||||
- | - | - | 8,357 | 5,432 | -4,699 | |
Supplemental cash flow information | ||||||
Cash paid for interest | ||||||
834 | 884 | 865 | - | - | - | |
Interest paid | ||||||
- | - | - | 1,166 | 3,591 | 243 | |
Cash paid for income taxes | ||||||
3 | 2 | 2 | 2 | - | - | |
Non-cash investing and financing activities: | ||||||
Acquisition of property and equipment under accounts payable and other accrued liabilities | ||||||
4,420 | 3,374 | 144 | 64 | 0 | - | |
Issuance of common stock in connection with equity line of credit | ||||||
- | - | 174 | 0 | - | - | |
Property and equipment acquired through capital lease | ||||||
- | - | 0 | - | - | - | |
Conversion of debt to equity | ||||||
- | - | - | - | 7,407 | 0 | |
Issuance of common stock in connection with debt financing | ||||||
- | - | - | - | - | 141 | |
Issuance of warrant in connection with debt financing | ||||||
- | - | - | - | 212 | 115 | |
Accrued deferred offering cost | ||||||
- | - | - | - | - | 1,062 | |
Unpaid offering costs | ||||||
188 | 0 | - | - | - | - | |
Right-of-use assets acquired under finance lease obligations | ||||||
22 | - | - | - | - | - | |
Right-of-use assets acquired under finance lease obligations | ||||||
- | 25 | - | - | - | - | |
Issuance of common stock warrants in connection with a build-to-suit obligation | ||||||
0 | 243 | 0 | - | - | - | |
Reclassification of warrant liability to equity | ||||||
- | - | - | - | 252 | 0 | |
Public Stock Offering | ||||||
Proceeds from offering of securities, net of costs | ||||||
18,331 | 45,604 | - | - | - | - | |
At-the-market Offering | ||||||
Proceeds from offering of securities, net of costs | ||||||
5,289 | 0 | - | - | - | - | |
Registered Direct Offering | ||||||
Proceeds from public offering of securities, net of commissions and offering costs | ||||||
3,162 | 0 | - | - | - | - | |